Grem1^ld
Radiation induced Allele Detail

Summary

• Symbol: Grem1^ld
• Name: gremlin 1, DAN family BMP antagonist; limb deformity
• MGI ID: MGI:1856289
• Synonyms: Fmn^ld, Fmn^ld-Or, ld, ld^OR
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^ld page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: This mutant allele was recovered at The Oak Ridge National Laboratory among descendants of an X-irradiated male. The allele contains a 12.7 kb deletion that eliminates the entire open reading frame encoded by exon 2. (J:13658, J:43337, J:91385)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

Notes

Possibly radiation induced (found in later generation descendants of X-irradiated male).

Originally called "severe appendicular abnormality."

This limb deformity allele was determined through complementation analysis to be allelic to limb deformity Jackson (Grem1^ld-J; J:22160), Fmn1^ld-TgBri137 (J:1741), and Fmn1^{ld-Is(17;In2)1Gso} (J:10399).

References

• Original: J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
• All: 16 reference(s)