Phenotypes associated with this allele
Allelic Composition |
Grem1ld/Grem1ld
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Genetic Background |
involves: 129S1/SvImJ or CD-1 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1ld mutation
(0 available);
any
Grem1 mutation
(16 available)
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renal/urinary system
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• Background Sensitivity: absence of both kidneys
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• absence of both ureters
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respiratory system
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• H&E staining of transversal sections show reduced numbers of alveoli in lings of mutatn mice compared with wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1ld mutation
(0 available);
any
Grem1 mutation
(16 available)
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limbs/digits/tail
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• by E10 limb buds of mutant embryos are narrower in the anterior-posterior aspect than seen in wild-type controls
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• mice exhibit severe oligodactyly on fore and hindfeet
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• mice exhibit severe syndactyly on fore and hindfeet
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• the radius and ulna appear as a single broad, flat bone
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• the fibula and tibia are replaced by a usually triangular shaped short bone
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• the tibia and fibula are replaced by a usually triangular shaped short bone
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renal/urinary system
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• 5 of 46 with 1 normal and 1 hypoplastic kidney
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• development of metanephric mesenchyme significantly retarded at E11.5
• mesenchyme differentiation does not occur if ureteric bud fails to reach the metanephric mesenchyme
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• reduced or absent kidneys
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• 7 of 46 lack both kidneys
(J:17401)
• reduced or absent kidneys
(J:22158)
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• 19 of 46 with one absent kidney
• 1 of 46 with only one, hypomorphic, kidney
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• has not reached the metanephric mesenchyme by E11.5
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skeleton
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• abnormalities occur distal to the humerus and femur
(J:22159)
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• the radius and ulna appear as a single broad, flat bone
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• the fibula and tibia are replaced by a usually triangular shaped short bone
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• the tibia and fibula are replaced by a usually triangular shaped short bone
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embryo
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• by E10 limb buds of mutant embryos are narrower in the anterior-posterior aspect than seen in wild-type controls
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Allelic Composition |
Alx4lst/Alx4+ Grem1ld/Grem1+
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Genetic Background |
Not Specified |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4lst mutation
(0 available);
any
Alx4 mutation
(20 available)
Grem1ld mutation
(0 available);
any
Grem1 mutation
(16 available)
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