All Phenotypes Grem1<ld> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grem1^ld/Grem1^ld	involves: 129S1/SvImJ or CD-1	MGI:5632139
hm2	Grem1^ld/Grem1^ld	Not Specified	MGI:3811470
cx3	Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺	Not Specified	MGI:4355956

Allelic Composition	Grem1^ld/Grem1^ld
Genetic Background	involves: 129S1/SvImJ or CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1^ld mutation (0 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:91385 )

• Background Sensitivity: absence of both kidneys

absent ureter ( J:91385 )

• absence of both ureters

respiratory system

abnormal pulmonary alveolus morphology ( J:91385 )

• H&E staining of transversal sections show reduced numbers of alveoli in lings of mutatn mice compared with wild-type controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb bud morphology ( J:46539 )

• by E10 limb buds of mutant embryos are narrower in the anterior-posterior aspect than seen in wild-type controls

oligodactyly ( J:22158 )

• mice exhibit severe oligodactyly on fore and hindfeet

syndactyly ( J:22158 )

• mice exhibit severe syndactyly on fore and hindfeet

fused radius and ulna ( J:22159 )

• the radius and ulna appear as a single broad, flat bone

abnormal fibula morphology ( J:22159 )

• the fibula and tibia are replaced by a usually triangular shaped short bone

abnormal tibia morphology ( J:22159 )

• the tibia and fibula are replaced by a usually triangular shaped short bone

renal/urinary system

abnormal kidney morphology ( J:17401 )

• 5 of 46 with 1 normal and 1 hypoplastic kidney

abnormal metanephric mesenchyme morphology ( J:17401 )

• development of metanephric mesenchyme significantly retarded at E11.5

• mesenchyme differentiation does not occur if ureteric bud fails to reach the metanephric mesenchyme

renal hypoplasia ( J:22158 )

• reduced or absent kidneys

absent kidney ( J:17401 , J:22158 )

• 7 of 46 lack both kidneys (J:17401)

• reduced or absent kidneys (J:22158)

single kidney ( J:17401 )

• 19 of 46 with one absent kidney

• 1 of 46 with only one, hypomorphic, kidney

abnormal ureteric bud elongation ( J:17401 )

• has not reached the metanephric mesenchyme by E11.5

skeleton

abnormal long bone morphology ( J:22158 , J:22159 )

• abnormalities occur distal to the humerus and femur (J:22159)