Phenotypes associated with this allele

• Allele Symbol: Stk11⁺
• Allele Name: wild type
• Allele ID: MGI:2437993
• Summary: 16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Stk11^tm1.1Mlfr/Stk11^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3616342
ht2	Stk11^tm1.2Rdp/Stk11^+	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	MGI:3814827
ht3	Stk11^tm1.2Rdp/Stk11^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3814533
ht4	Stk11^tm1.1Rdp/Stk11^+	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3814532
ht5	Stk11^tm1.2Rdp/Stk11^+	involves: 129S6/SvEvTac * FVB/N	MGI:3774860
ht6	Stk11^tm1Tpm/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790955
ht7	Stk11^tm1.1Jish/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2676549
ht8	Stk11^tm1Mmt/Stk11^+	involves: 129X1/SvJ	MGI:3851987
ht9	Stk11^tm1Tpm/Stk11^+	Not Specified	MGI:3790954
cn10	Stk11^tm1.1Rdp/Stk11^+ Tagln^tm1(cre/ERT2)Feil/Tagln^+	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	MGI:3814821
cx11	Stk11^tm1.1Mlfr/Stk11^+ Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3616343
cx12	Stk11^tm1.1Mlfr/Stk11^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3616344
cx13	Stk11^tm1Mmt/Stk11^+ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3851991
cx14	Stk11^tm1Mmt/Stk11^+ Trp53^tm1Brd/Trp53^+	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3851992
cx15	Ptgs2^tm1Jed/Ptgs2^+ Stk11^tm1Tpm/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790958
cx16	Ptgs2^tm1Jed/Ptgs2^tm1Jed Stk11^tm1Tpm/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790956

Genotype
MGI:3616342

ht1

• Allelic Composition: Stk11^tm1.1Mlfr/Stk11⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:104347 )

• mice have reduced life spans with 50% dying before 14 months of age

growth/size/body

distended abdomen ( J:104347 )

• abdomen becomes increasingly distended during aging

visceromegaly ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the spleen, lung, liver, stomach, and intestine

enlarged liver ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the liver

enlarged spleen ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the spleen

digestive/alimentary system

abnormal intestine morphology ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the intestine

enlarged stomach ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the stomach

gastric polyps ( J:104347 )

• at 6 months of age, polyps are observed, and by 6.5 months, approximately 75% of mice have gastrointestinal polyps

• polyps are mainly located at the junction of the pylorus and duodenum with a few found in the antrum and fundus of the stomach

• polyps in the pylorus are large while those in the antrum or fundus are smaller

• large polyps in the pylorus protrude into the duodenum causing gross distention and obstruction

neoplasm

increased hamartoma incidence ( J:104347 )

• all of the polyps are hamartomas

liver/biliary system

enlarged liver ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the liver

immune system

enlarged spleen ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the spleen

hematopoietic system

enlarged spleen ( J:104347 )

• 9 of 13 heterozygotes displayed organomegaly of the spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:104347

Genotype
MGI:3814827

ht2

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

mortality/aging

premature death ( J:134476 )

• mice die at average age of 12.5 months

digestive/alimentary system

gastrointestinal tract polyps ( J:134476 )

• 100% of animals have gastrointestinal polyps at 11 months

• average polyp size is larger than in Stk11-conditional mutants

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

neoplasm

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

Genotype
MGI:3814533

ht3

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

mortality/aging

premature death ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA succumb to skin and lung cancers (18/42 mice) with median survival of 28.6 weeks compared to wild-type mice which remain cancer-free for >40 weeks

digestive/alimentary system

gastrointestinal tract polyps ( J:78818 )

• polyps are present throughout gastrointestinal tract, including the stomach and colon

colon polyps ( J:78818 )

gastric polyps ( J:78818 )

abnormal digestive system physiology ( J:78818 )

• at 43 weeks, mice present with gastrointestinal obstruction

intestinal obstruction ( J:78818 )

neoplasm

increased tumor incidence ( J:78818 , J:131037 )

• one animal exhibited a benign serous cyadenoma of the pancreas, and 2 showed asymptomatic benign uterine epithelial tumors, but no other neoplasms were observed in mutants (J:78818)

• mice have reduced cancer-free survival (28.6 weeks) relative to wild-type (>40 weeks) (J:131037)

• mutants are sensitized to squamous cell carcinoma compared to wild-type (J:131037)

increased incidence of tumors by chemical induction ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA (to promote development of lymphomas, sarcomas and lung adenomas) develop invasive skin and lung cancers not seen in wild-type mice

increased hamartoma incidence ( J:78818 )

• polyps present as mucosal hamartomas without dysplastic or adenomatous changes

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA (to promote development of lymphomas, sarcomas and lung adenomas) develop invasive skin and lung cancers not seen in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:78818 , J:131037

Genotype
MGI:3814532

ht4

• Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:78818 )

• animals are born at expected frequency and show no gross abnormalities

Genotype
MGI:3774860

ht5

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

neoplasm

increased endometrial carcinoma incidence ( J:131865 )

♀ • 53% of female mice that survive to 55 weeks of age have endometrial adenocarcinomas that developed spontaneously

♀ • tumors consisted of endometrial-type glands invading into the myometrium

♀ • tumors maintained polarity of cells found in normal endometrial glands

digestive/alimentary system

intestine polyps ( J:131865 )

• 40 of 59 mice develop gastrointestinal polyps by 43 weeks of age

reproductive system

increased endometrial carcinoma incidence ( J:131865 )

♀ • 53% of female mice that survive to 55 weeks of age have endometrial adenocarcinomas that developed spontaneously

♀ • tumors consisted of endometrial-type glands invading into the myometrium

♀ • tumors maintained polarity of cells found in normal endometrial glands

Genotype
MGI:3790955

ht6

• Allelic Composition: Stk11^tm1Tpm/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

digestive/alimentary system

intestine polyps ( J:93361 )

• polyposis detected at 4-5 months

• treatment with celecoxib (Ptgs2 inhibitor) between 3.5 and 10 months reduces number of large polyps observed; similar results are obtained when treatment is performed at 6.5-10 months in mice on 129S7/SvEvBrd * CD-1 background

• microvessel density is reduced in polyps with celecoxib treatment

gastric polyps ( J:93361 )

• polyposis detected at 4-5 months

• treatment with celecoxib (Ptgs2 inhibitor) between 3.5 and 10 months reduces number of large polyps observed; similar results are obtained when treatment is performed at 6.5-10 months in mice on 129S7/SvEvBrd * CD-1 background

• microvessel density is reduced in polyps with celecoxib treatment

neoplasm

decreased tumor incidence ( J:93361 )

• 86% decrease in tumor burden is seen at 10 months in mice treated with celecoxib between 3.5 and 10 months compared to untreated controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:93361

Genotype
MGI:2676549

ht7

• Allelic Composition: Stk11^tm1.1Jish/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Stk11^tm1.1Jish/Stk11⁺ mice develop gastrointestinal polyps

neoplasm

increased adenoma incidence ( J:77213 )

• all mice showed gastric adenomatous polyps at 10 and 14 months of age, predominantly in the glandular stomach

increased intestinal adenoma incidence ( J:77213 )

digestive/alimentary system

increased intestinal adenoma incidence ( J:77213 )

gastric polyps ( J:77213 )

• mutants develop polyps by 10 months of age; most polyps localize at the junction of pyloric antrum and duodenum in the glandular stomach

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:77213

Genotype
MGI:3851987

ht8

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺
• Genetic Background: involves: 129X1/SvJ

mortality/aging

premature death ( J:76202 )

• some mice die after 50 weeks while others survive beyond 70 weeks

neoplasm

increased tumor incidence ( J:76202 )

• tumor cells proliferate continuously in the polyps

increased hepatocellular carcinoma incidence ( J:76202 )

• after 30 weeks in most mice

increased hamartoma incidence ( J:76202 , J:107275 )

• polyps exhibit characteristics of hamartomas (J:76202)

• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice (J:107275)

• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs (J:107275)

digestive/alimentary system

gastric polyps ( J:76202 )

• after 20 weeks, 93% of mice develop gastric polyps unlike wild-type mice

• after 40 weeks, all mice develop gastric polyps unlike in wild-type mice

• polyps develop in the glandular stomach and small intestine of older mice

• after 50 weeks, 31% of mice develop small intestinal polyps unlike wild-type mice

• small polyps are sessile while larger ones are pedunculated and consist of glandular and cystic epithelial layers

liver/biliary system

increased hepatocellular carcinoma incidence ( J:76202 )

• after 30 weeks in most mice

Genotype
MGI:3790954

ht9

• Allelic Composition: Stk11^tm1Tpm/Stk11⁺
• Genetic Background: Not Specified

mortality/aging

premature death ( J:79074 )

• 80% die by 16 months of age

growth/size/body

distended abdomen ( J:79074 )

• noted as mice age

digestive/alimentary system

intestine polyps ( J:79074 )

duodenum polyps ( J:79074 )

• grossly distended by large polyps

gastric polyps ( J:79074 )

• all mice >6 months of age have macroscopic gastrointestinal polyps; majority are found in glandular stomach with equal distribution in fundus, antrum, and pylorus

• in most animals, 1-3 large polyps (20-30 mm in diameter) originate in pylorus and protrude into duodenum

• all polyps have extensive well-developed smooth muscle component originating from central stalk contiguous with muscularis mucosa

intestinal obstruction ( J:79074 )

• results from protrusion of large polyps into lumen

neoplasm

increased hepatocellular carcinoma incidence ( J:79074 )

• seen in one animal; incidence similar to age-matched controls

increased liver adenoma incidence ( J:79074 )

• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls

increased hemangioma incidence ( J:79074 )

• seen in one animal; incidence similar to age-matched controls

increased endometrial carcinoma incidence ( J:79074 )

♀ • seen in one animal; incidence similar to age-matched controls

liver/biliary system

increased hepatocellular carcinoma incidence ( J:79074 )

• seen in one animal; incidence similar to age-matched controls

increased liver adenoma incidence ( J:79074 )

• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls

reproductive system

increased endometrial carcinoma incidence ( J:79074 )

♀ • seen in one animal; incidence similar to age-matched controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:79074

Genotype
MGI:3814821

cn10

• Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺; Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

mortality/aging

premature death ( J:134476 )

• almost 50% of tamoxifen-treated animals die by 18 months from gastrointestinal obstruction (average lifespan 13.5 months); widespread gastrointestinal polyposis is found at time of necropsy

digestive/alimentary system

digestive/alimentary phenotype ( J:134476 )

N • with 2 intraperitoneal injections of tamoxifen at 6 weeks of age, no abnormalities are seen at 3 and 8 months of age

gastrointestinal tract polyps ( J:134476 )

• at 11 months, gastrointestinal tract polyps are observed in <60% of tamoxifen-treated animals

• average polyp size is smaller than in Stk11^tm1.2Rdp/+ mice at 11 months

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia

intestinal obstruction ( J:134476 )

• at 11 months, mice present with severe gastrointestinal obstruction

neoplasm

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia

Genotype
MGI:3616343

cx11

• Allelic Composition: Stk11^tm1.1Mlfr/Stk11⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

mortality/aging

premature death ( J:104347 )

• Approximately 50% die by 10 months of age, significantly sooner than either single heterozygote

digestive/alimentary system

gastric polyps ( J:104347 )

• time to onset of polyposis is similar to single heterozygotes

• 92% of moribund mice between 7 and 14 months of age have gastrointestinal polyps

• polyps are not found before 5.5 months of age, but at 6.5 months are seen in 60% of mice

growth/size/body

distended abdomen ( J:104347 )

• mice have enlarged abdomens due to presence of polyps in pylorus and duodenum

neoplasm

increased hamartoma incidence ( J:104347 )

• polyps are hamartomas

• tumor-free survival rate is about 11 months compared with 17 months for Trp53 single heterozygotes

• 23 of 38 (61%) of double heterozygotes developed a total of 30 tumors

increased lymphoma incidence ( J:104347 )

• 20% (6 of 30) tumors are lymphomas

increased sarcoma incidence ( J:104347 )

• 10% (3 of 30) of the tumors are sarcomas

increased osteosarcoma incidence ( J:104347 )

• 43% of the tumors (13 of the 30) are osteosarcomas

skeleton

increased osteosarcoma incidence ( J:104347 )

• 43% of the tumors (13 of the 30) are osteosarcomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:104347

Genotype
MGI:3616344

cx12

• Allelic Composition: Stk11^tm1.1Mlfr/Stk11⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

mortality/aging

premature death ( J:104347 )

• mice have median age of survival of 4.5 months, similar to Trp53 homozygotes

digestive/alimentary system

colon polyps ( J:104347 )

• 2 of 7 mice have polyps on their lare intestines

neoplasm

increased hamartoma incidence ( J:104347 )

• hamartomatous polyps can be identified at 4.3 months of age, earlier than in double heterozygotes or Stk11 single heterozygotes

Genotype
MGI:3851991

cx13

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

mortality/aging

premature death ( J:107275 )

• mice by at 7 months

neoplasm

increased tumor incidence ( J:107275 )

• at 25 weeks, one mouse develops bladder tumor unlike wild-type mice

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

increased hamartoma incidence ( J:107275 )

• after 12 weeks, all mice develop gastric hamartomas unlike wild-type mice

liver/biliary system

abnormal hepatocyte morphology ( J:107275 )

• enlarged and dysplastic in nodules

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

reproductive system

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

endocrine/exocrine glands

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

Genotype
MGI:3851992

cx14

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

neoplasm

increased hamartoma incidence ( J:107275 )

• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice

• at 24 weeks, all mice develop gastric hamartomas unlike wild-type mice

• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs

Genotype
MGI:3790958

cx15

• Allelic Composition: Ptgs2^tm1Jed/Ptgs2⁺; Stk11^tm1Tpm/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

digestive/alimentary system

intestine polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

gastric polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

Genotype
MGI:3790956

cx16

• Allelic Composition: Ptgs2^tm1Jed/Ptgs2^tm1Jed; Stk11^tm1Tpm/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

digestive/alimentary system

intestine polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

gastric polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

neoplasm

decreased tumor incidence ( J:93361 )

• 53-54% decrease in tumor burden is seen at 10 months in mice treated with celecoxib between 3.5 and 10 months compared to untreated controls