Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gja10+ wild type MGI:2437872 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the dark resting potential of horizontal cells is significantly more depolarized than wild-type controls but is not as depolarized as in homozygotes
• the maximal full-field response amplitudes of horizontal cells is significantly reduced but not to the extent that occurs in homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the outer retina shows severe changes following horizontal cell ablation with diphtheria toxin (DT) treatment including loss of synaptic contacts and cone pedicle mosaic restructuring
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• shape and arrangement of cone pedicles are changed following DT treatment; pedicles show atrophy and form complex clusters
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• after DT treatment, many rod photoreceptors retract their terminals, while cone pedicles form clusters
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• with horizontal cell ablation, many rod photoreceptors are lost, while cone number is not significantly affected
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• at 8 weeks and 6 months after DT treatment, normal columnar alignment of photoreceptor nuclei is disrupted; about one third of photoreceptor nuclei are lost in treated mice
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• after diphtheria toxin (DT) injection to retinal ablate horizontal cells in adult animals, the outer plexiform layer appears thinner at 2 weeks after treatment and is almost completely absent at 6 months
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• under scotopic conditions, 6 months after treatment, a-wave amplitudes are significantly lower than in wild-type retina for intensities >0.5 cds/sq. meter and b-wave amplitudes are lower than wild-type for intensities >0.005 cds/sq. meter
• photopic electroretinograms show similar effects with the b-wave increasing with increasing light intensities in wild-type but not mutants
• ON responses (time to peak) are slower in retinae of treated mice while OFF responses are not significantly different, indicating that ganglion cell responses in treated mice are just mildly affected
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• visual performance (visual acuity and contrast sensitivity) in DT-treated mutants is slightly lower than in wild-type despite morphology changes in outer retina
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• shape and arrangement of cone pedicles are changed following DT treatment; pedicles show atrophy and form complex clusters
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• after DT treatment, many rod photoreceptors retract their terminals, while cone pedicles form clusters
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• with horizontal cell ablation, many rod photoreceptors are lost, while cone number is not significantly affected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinal horizontal cells show significantly smaller glutamate- or AMPA-induced inward currents than controls
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• somas of horizontal cells show significantly smaller glutamate- or AMPA-induced inward currents (by about 75%) compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following infection with adeno-associated viruses that express a single-guide RNA targeting Amigo1 and a fluorescent reporter (AAV2/1-U6-sgAmigo1-CAG-tdTomato), the size of axons of infected horizontal cells is reduced and some branches stray into the outer nuclear layers
• however, the number of dendritic and axonal synapses and the size of horizontal cell dendrites is normal
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• following infection with adeno-associated viruses that express a single-guide RNA targeting Amigo1 and a fluorescent reporter (AAV2/1-U6-sgAmigo1-CAG-tdTomato), the size of axons of infected horizontal cells is reduced and some branches stray into the outer nuclear layers
• however, the number of dendritic and axonal synapses and the size of horizontal cell dendrites is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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