Gja10tm2(Hbegf/EGFP)Kwi
Targeted Allele Detail
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Symbol: |
Gja10tm2(Hbegf/EGFP)Kwi |
Name: |
gap junction protein, alpha 10; targeted mutation 2, Klaus Willecke |
MGI ID: |
MGI:5433359 |
Synonyms: |
Cx57DTR, Cx57-DTRfrtCre |
Gene: |
Gja10 Location: Chr4:32596960-32602760 bp, - strand Genetic Position: Chr4, 14.25 cM
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Alliance: |
Gja10tm2(Hbegf/EGFP)Kwi page
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion
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Gja10tm2(Hbegf/EGFP)Kwi expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
Not Specified |
Hbegf |
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Mutation details: Homologous recombination replaced most of exon 2 with an FRT-flanked sequence encoding an HBEGF/EGFP (DTR/EGFP) fusion protein followed by cre recombinase with a nuclear localization signal. A PGK-neo selection cassette was inserted into intron 2. The diphtheria toxin receptor (HBEGF or DTR) is expressed from the Gja10 promoter and can be removed by flp-mediated recombination, leaving cre recombinase under control of the promoter.
(J:167075, J:186624)
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Generation of Gja10tm2(Hbegf/EGFP)Kwi |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gja10 Mutation: |
24 strains or lines available
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Original: |
J:186624 Sonntag S, et al., Ablation of retinal horizontal cells from adult mice leads to rod degeneration and remodeling in the outer retina. J Neurosci. 2012 Aug 1;32(31):10713-24 |
All: |
5 reference(s) |
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