Gja10^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gja10^tm1Kwi
• Name: gap junction protein, alpha 10; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:3043946
• Synonyms: Cx57-, Cx57^lacZ
• Gene: Gja10 Location: Chr4:32596960-32602760 bp, - strand Genetic Position: Chr4, 14.25 cM
• Alliance: Gja10^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90294
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 encoding amino acids 1 through 346 was replaced with a cassette containing lacZ and neo genes by homologous recombination. Northern blot analyses of retina confirmed the absence of RNA in homozygous mutant mice. The expression pattern of lacZ was similar to that of the endogenous gene. (J:90294, J:128358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja10 Mutation: 22 strains or lines available

References

• Original: J:90294 Hombach S, et al., Functional expression of connexin57 in horizontal cells of the mouse retina. Eur J Neurosci. 2004 May;19(10):2633-40
• All: 6 reference(s)