All Phenotypes Nfkb2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nfkb2⁺
wild type
MGI:2434941

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nfkb2^Lym1/Nfkb2⁺	BALB/c-Nfkb2^Lym1	MGI:4412047
ht2	Nfkb2^tm1Brv/Nfkb2⁺	involves: 129S1/Sv * C57BL/6	MGI:3852510
ht3	Nfkb2^Lym1/Nfkb2⁺	involves: BALB/c	MGI:5446430
cn4	Nfkb2^Lym1/Nfkb2⁺ Otub1^{tm1c(EUCOMM)Hmgu}/Otub1^{tm1c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6N	MGI:6387024
cx5	Nfkb2^tm2Brv/Nfkb2⁺ Traf3^tm1Bal/Traf3^tm1Bal	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:4352678
cx6	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2⁺	involves: 129S1/Sv * C57BL/6	MGI:3852531

Allelic Composition	Nfkb2^Lym1/Nfkb2⁺
Genetic Background	BALB/c-Nfkb2^Lym1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2^Lym1 mutation (2 available); any Nfkb2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased lymphocyte cell number ( J:154812 )

• increased number of circulating lymphocytes

abnormal spleen white pulp morphology ( J:154812 )

• abnormalities in splenic architecture in heterozygous mice are intermediate between that of wild-type and homozygous null mice

immune system

absent Peyer's patches ( J:154812 )

increased lymphocyte cell number ( J:154812 )

• increased number of circulating lymphocytes

abnormal spleen white pulp morphology ( J:154812 )

• abnormalities in splenic architecture in heterozygous mice are intermediate between that of wild-type and homozygous null mice

abnormal lymph node morphology ( J:154812 )

abnormal mesenteric lymph node morphology ( J:154812 )

• mesenteric lymph nodes are present, but are reduced in size and cellularity

decreased lymph node number ( J:154812 )

absent axillary lymph nodes ( J:154812 )

absent brachial lymph nodes ( J:154812 )

absent cervical lymph nodes ( J:154812 )

absent inguinal lymph nodes ( J:154812 )

liver inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the liver of heterozygous mice

lung inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the lung of heterozygous mice

liver/biliary system

liver inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the liver of heterozygous mice

respiratory system

lung inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the lung of heterozygous mice

digestive/alimentary system

absent Peyer's patches ( J:154812 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
common variable immunodeficiency		DOID:12177	OMIM:PS607594	J:206674

Allelic Composition	Nfkb2^tm1Brv/Nfkb2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2^tm1Brv mutation (0 available); any Nfkb2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

stomach epithelial hyperplasia ( J:43469 )

• at 10 months, mice exhibit mild gastric hyperplasia compared to in wild-type mice

Allelic Composition	Nfkb2^Lym1/Nfkb2⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2^Lym1 mutation (2 available); any Nfkb2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:188560 )

• defect in the production of IgA+ B cells in response to anti-CD40 and BAFF

hematopoietic system

abnormal B cell differentiation ( J:188560 )

• defect in the production of IgA+ B cells in response to anti-CD40 and BAFF

Allelic Composition	Nfkb2^Lym1/Nfkb2⁺ Otub1^{tm1c(EUCOMM)Hmgu}/Otub1^{tm1c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6N
Cell Lines	HEPD0539_8_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Nfkb2^Lym1 mutation (2 available); any Nfkb2 mutation (52 available)
Otub1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Otub1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:280549 )

N	• mice show rescue of the defect in peripheral B cells, with an increase in total peripheral B cells, mature B cells, and follicular and MZ B cells

Allelic Composition	Nfkb2^tm2Brv/Nfkb2⁺ Traf3^tm1Bal/Traf3^tm1Bal
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2^tm2Brv mutation (1 available); any Nfkb2 mutation (52 available)
Traf3^tm1Bal mutation (0 available); any Traf3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:124635 )

• unlike Traf3^tm1Bal homozygotes, mice survive until 18 days

Allelic Composition	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1^tm1Brv mutation (0 available); any Nfkb1 mutation (104 available)
Nfkb2^tm1Brv mutation (0 available); any Nfkb2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:44112 )

• mice exhibit only subtle changes in bone structure

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

immune system

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

hematopoietic system

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

cellular

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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