Traf3^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Traf3^tm1Bal
• Name: TNF receptor-associated factor 3; targeted mutation 1, David Baltimore
• MGI ID: MGI:2135257
• Synonyms: TRAF3^-
• Gene: Traf3 Location: Chr12:111132804-111233587 bp, + strand Genetic Position: Chr12, 60.94 cM, cytoband F
• Alliance: Traf3^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37065
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the first two exons. Western blot analysis using a polyclonal antibody against the C-terminal portion did not detect protein in three tissues of homozygous mutant mice. Northern blot analysis using a cDNA fragment that encodes the C-terminus did not detect mRNA in brain of homozygous mutant mice. (J:37065)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf3 Mutation: 41 strains or lines available

References

• Original: J:37065 Xu Y, et al., Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity. 1996 Nov;5(5):407-15
• All: 9 reference(s)