Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ext1+ wild type MGI:2434557 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the rib bones from 4 of 16 mice
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• in the rib bones from 4 of 16 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no observable bone deformities or exostoses at E14.5 or E18.5
no observable bone deformities or exostoses at E14.5 or E18.5
• humeri, femora, and tibias all normal in length an ossification at E18.5 although increased variability observed
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• enlarged
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Thin cornea and iridocorneal dysgenesis in Ext1tm1Yama/Ext1+ H2az2Tg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ mice
| N |
• mice survive into adulthood
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• mice exhibit defects in components of the aqueous drainage system
• however, the iridocorneal angle is normal
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• the trabecular beam contains fewer cells than in wild-type mice
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• mice exhibit ocular hypertension unlike single heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable embryos are recovered at E11.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• with doxycycline induction of cre activity during gestation, only 1 pup was observed
• without doxycycline induction during gestation, viable offspring are generated
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| N |
• mice exhibit no osteochondromas at 6-10 weeks of age with doxycycline induction from P8 to 15
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no animals are recovered at weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 59-67% of retinal axons project ectopically into the contralateral optic nerve
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• 59-67% of retinal axons project ectopically into the contralateral optic nerve
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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