All Phenotypes Lepr<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lepr⁺
wild type
MGI:2433523

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lepr^tm1.1Rll/Lepr⁺	129P3/J-Lepr^tm1.1Rll	MGI:5049865
ht2	Lepr^tm1Mgmj/Lepr⁺	B6.129-Lepr^tm1Mgmj	MGI:3697522
ht3	Lepr^tm3.1Yli/Lepr⁺	B6.129-Lepr^tm3.1Yli	MGI:4820763
ht4	Lepr^db/Lepr⁺	B6.Cg-Dock7^m +/+ Lepr^db/J	MGI:3697525
ht5	Lepr^tm2Mgmj/Lepr⁺	B6.Cg-Lepr^tm2Mgmj	MGI:3713770
ht6	Lepr^Db-2Btlr/Lepr⁺	C57BL/6J-Lepr^Db-2Btlr	MGI:3785475
ht7	Lepr^Db-Btlr/Lepr⁺	C57BL/6J-Lepr^Db-Btlr	MGI:3784990
ht8	Lepr^m6Btlr/Lepr⁺	C57BL/6J-Lepr^m6Btlr	MGI:5609711
ht9	Lepr^db/Lepr⁺	involves: C57BLKS/J	MGI:3774843
cn10	Lepr^tm1.1Chua/Lepr⁺ Tg(Gh1-cre)bKnmn/0	involves: 129 * C57BL/6 * FVB	MGI:5014261
cn11	Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5705239
cn12	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ Tg(Tek-cre)12Flv/0	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL	MGI:5306357
cn13	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL	MGI:5306356
cn14	Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Lepr^tm2(cre)Rck/Lepr⁺	involves: C57BL/6	MGI:5488610
cx15	Dock7^m/Dock7⁺ Lepr^db/Lepr⁺	BKS.Cg-Dock7^m +/+ Lepr^db/J	MGI:3776095
cx16	Lepr^db/Lepr⁺ Tg(APPswe,PSEN1dE9)85Dbo/0	involves: C3H * C57BL/6 * C57BLKS/J	MGI:5435319
cx17	Dbsq2^C57BLKS/J/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺	involves: C3H/HeJ * C57BLKS	MGI:3693606
cx18	Dbsq2^C3H/HeJ/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺	involves: C3H/HeJ * C57BLKS	MGI:3693605
cx19	Dbsq3^C57BLKS/J/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺	involves: C3H/HeJ * C57BLKS	MGI:3693608
cx20	Dbsq3^C3H/HeJ/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺	involves: C3H/HeJ * C57BLKS	MGI:3693607

Allelic Composition	Lepr^tm1.1Rll/Lepr⁺
Genetic Background	129P3/J-Lepr^tm1.1Rll

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Rll mutation (0 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to parasitic infection ( J:172012 )

• E. histolytica-infected mice exhibit increased infection, more severe epithelial ulceration, and greater intestinal epithelial cell apoptosis compared to in similarly treated wild-type mice

digestive/alimentary system

increased enterocyte apoptosis ( J:172012 )

• in E. histolytica-infected mice

cellular

increased enterocyte apoptosis ( J:172012 )

• in E. histolytica-infected mice

Allelic Composition	Lepr^tm1Mgmj/Lepr⁺
Genetic Background	B6.129-Lepr^tm1Mgmj

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1Mgmj mutation (1 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:82334 )

• slight but significant increase in body weight compared to wild-type mice

Allelic Composition	Lepr^tm3.1Yli/Lepr⁺
Genetic Background	B6.129-Lepr^tm3.1Yli

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm3.1Yli mutation (0 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to age related obesity ( J:161732 )

• both male and female heterozygous mice displayed the same tendency of age-dependent increases in body fat mass, with intermediate degrees of adiposity observed at 51 weeks of age compared to WT and homozygous animals

adipose tissue

increased percent body fat/body weight ( J:161732 )

Allelic Composition	Lepr^db/Lepr⁺
Genetic Background	B6.Cg-Dock7^m +/+ Lepr^db/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:6081 )

• increased survival when totally deprived of food than wild-type controls

• Background Sensitivity: survival when deprived of food is not as long as when in a C57BLKsS background

growth/size/body

increased body weight ( J:82334 )

• slight but significant increase in body weight compared to wild-type mice

Allelic Composition	Lepr^tm2Mgmj/Lepr⁺
Genetic Background	B6.Cg-Lepr^tm2Mgmj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm2Mgmj mutation (1 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:122056 )

• in young females fed ad libitum or older females on a high fat diet

Allelic Composition	Lepr^Db-2Btlr/Lepr⁺
Genetic Background	C57BL/6J-Lepr^Db-2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-2Btlr mutation (0 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:133633 )

• mice heterozygous for this mutation are heavier than wild-type controls

Allelic Composition	Lepr^Db-Btlr/Lepr⁺
Genetic Background	C57BL/6J-Lepr^Db-Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-Btlr mutation (1 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:133632 )

• mice heterozygous for this mutation are heavier than wild-type controls

Allelic Composition	Lepr^m6Btlr/Lepr⁺
Genetic Background	C57BL/6J-Lepr^m6Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^m6Btlr mutation (0 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:216794 )

• mice heterozygous for this mutation exhibit a significantly increased body weight, intermediate between those of homozyous mutant and and wild-type mice, but not significant enough to consider the allele semidominant.

Allelic Composition	Lepr^db/Lepr⁺
Genetic Background	involves: C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:71934 )

increased circulating glucose level ( J:71934 )

• fasting glucose levels elevated 25% during pregnancy

impaired glucose tolerance ( J:71934 , J:219658 )

• profound glucose intolerance during pregnancy (J:71934)

• glucose levels 41% higher in a glucose tolerance test at 30 and at 60 minute time points (J:71934)

• 45-55% higher glucose levels after a glucose challenge but dramatically improved by leptin treatment and glucose levels reduced 33 and 30% in glucose tolerance tests at 30 and 60 minute time points (J:71934)

• females exhibit impaired glucose tolerance during pregnancy (J:219658)

• both male and female heterozygous offspring have impaired glucose tolerance irrespective of maternal environment (heterozygous or wild-type mothers) (J:219658)

abnormal hormone level ( J:71934 )

• elevated placental leptin levels in pregnant females

abnormal circulating insulin level ( J:71934 )

• 2.2X increase in fasting insulin during pregnancy compared to a 3X increase in controls

• leptin treatment results in a 14% reduction in insulin levels compared to a 45% reduction in controls

decreased circulating insulin level ( J:219658 )

• pregnant dams exhibit lower fasting insulin levels than wild-type mothers

increased circulating leptin level ( J:219658 )

• mothers exhibit higher circulating leptin levels than wild-type mothers

• heterozygous offspring exhibit an increase in leptin levels at 6 months of age

decreased response to leptin ( J:71934 )

• birth weights significantly heavier than controls and unaffected by maternal leptin treatment unlike controls where maternal leptin treatment causes a decrease in birth weights

• leptin treatment results in a 14% reduction in insulin levels compared to a 45% reduction in controls

embryo

enlarged placenta ( J:219658 )

• placentas from heterozygous fetuses are larger than those of wild-type fetuses, irrespective of maternal genotype

behavior/neurological

increased food intake ( J:71934 )

• food intake 11% greater than controls during pregnancy

• leptin treatment suppresses food intake to near control levels

growth/size/body

increased birth weight ( J:219658 )

• heterozygous fetuses carried by wild-type dams exhibit a 5% higher birth weight than wild-type littermates

• heterozygous fetuses from heterozygous mothers are 3% bigger than wild-type littermates

• however, wild-type pups from heterozygous mothers are no bigger than wild-type fetuses carried by wild-type mothers

increased body weight ( J:219658 )

• heterozygous pregnant dams are heavier than wild-type mothers at E18.5

• male and female heterozygous offspring from both normal and complicated pregnancies, are heavier than wild-type littermates at 3 and 6 months of age

increased susceptibility to weight gain ( J:71934 )

• 33% greater maternal weight gain

• maternal body weight at term 24% greater than controls

adipose tissue

increased total body fat amount ( J:71934 )

• 20% greater adipose tissue mass during pregnancy than in controls

cellular

maternal effect ( J:219658 )

• wild-type males born to heterozygous mothers are heavier than wild-type mice born to wild-type mothers, but postnatal weight gain of female offspring is not affected by the maternal environment

• offspring born from heterozygous mothers with gestational diabetes have lower fasting insulin levels and worse glucose tolerance than offspring born from wild-type mothers

Allelic Composition	Lepr^tm1.1Chua/Lepr⁺ Tg(Gh1-cre)bKnmn/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (124 available)
Tg(Gh1-cre)bKnmn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased somatotroph cell number ( J:173444 )

• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

nervous system

decreased somatotroph cell number ( J:173444 )

• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

reproductive system

reproductive system phenotype ( J:173444 )

N	• mice are fertile

Allelic Composition	Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2^tm2Mfw mutation (0 available); any Irs2 mutation (37 available)
Irs4^tm1.1Mfw mutation (0 available); any Irs4 mutation (6 available)
Lepr^tm3(cre)Mgmj mutation (1 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221293 )

N	• blood glucose levels are similar to controls

growth/size/body

growth/size/body region phenotype ( J:221293 )

N	• body weight is essentially similar to homozygous Irs2^tm2Mfw / heterozygous Lepr^tm3(cre)Mgmj male mice

Allelic Composition	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^tm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Lepr^tm2(cre)Rck mutation (1 available); any Lepr mutation (124 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

spleen hyperplasia ( J:180431 )

decreased bone marrow cell number ( J:180431 )

decreased hematopoietic cell number ( J:180431 )

• in the bone marrow

immune system

spleen hyperplasia ( J:180431 )

growth/size/body

spleen hyperplasia ( J:180431 )

Allelic Composition	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

extramedullary hematopoiesis ( J:180431 )

• in the spleen

decreased hematopoietic cell number ( J:180431 )

• in the bone marrow and the spleen

• depletion in the bone marrow increases over time

immune system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

growth/size/body

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

Allelic Composition	Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Lepr^tm2(cre)Rck/Lepr⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12^tm1.1Sjm mutation (1 available); any Cxcl12 mutation (23 available)
Lepr^tm2(cre)Rck mutation (1 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:194748 )

• increased hematopoietic cells and colony forming cells in the blood and spleen

Allelic Composition	Dock7^m/Dock7⁺ Lepr^db/Lepr⁺
Genetic Background	BKS.Cg-Dock7^m +/+ Lepr^db/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock7^m mutation (14 available); any Dock7 mutation (110 available)
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:6081 )

• increased survival when totally deprived of food than wild-type controls

• Background Sensitivity: survival when deprived of food is longer rhan when in a C57BL/6 background

Allelic Composition	Lepr^db/Lepr⁺ Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background	involves: C3H * C57BL/6 * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^db mutation (18 available); any Lepr mutation (124 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

amyloidosis ( J:186924 )

• mutants exhibit an increase in expression of amyloid beta protein in plasma compared to Lepr^db heterozygotes, however they do not show amyloid beta plaques yet at 5-7 weeks of age

increased circulating glucose level ( J:186924 )

• nonfasting blood glucose levels are elevated compared to control Lepr^db heterozygotes

• however, fasting blood glucose is normal at 5-7 weeks of age

increased circulating insulin level ( J:186924 )

• nonfasting and fasting hyperinsulinemia

abnormal circulating cholesterol level ( J:186924 )

• elevation in nonfasting plasma cholesterol levels

• however, fasting cholesterol levels are normal

impaired glucose tolerance ( J:186924 )

insulin resistance ( J:186924 )

• mutants exhibit decreased insulin sensitivity

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:186924 )

• increase in beta cell mass and beta cell area compared to control Lepr^db heterozygotes

growth/size/body

growth/size/body region phenotype ( J:186924 )

N	• body weight is normal at 5-7 weeks of age

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:186924
type 2 diabetes mellitus	DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:186924

Allelic Composition	Dbsq2^C57BLKS/J/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺
Genetic Background	involves: C3H/HeJ * C57BLKS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbsq2^C3H/HeJ mutation (0 available); any Dbsq2 mutation (0 available)
Dbsq2^C57BLKS/J mutation (0 available); any Dbsq2 mutation (0 available)
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:116038 )

• increased body weight in males at 7, 8, 9, 10 weeks of age and at sacrifice

Allelic Composition	Dbsq2^C3H/HeJ/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺
Genetic Background	involves: C3H/HeJ * C57BLKS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbsq2^C3H/HeJ mutation (0 available); any Dbsq2 mutation (0 available)
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:116038 )

• increased body weight in males at 7, 8, 9, 10 weeks of age and at sacrifice

Allelic Composition	Dbsq3^C57BLKS/J/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺
Genetic Background	involves: C3H/HeJ * C57BLKS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbsq3^C3H/HeJ mutation (0 available); any Dbsq3 mutation (0 available)
Dbsq3^C57BLKS/J mutation (0 available); any Dbsq3 mutation (0 available)
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:116038 )

• increased blood glucose concentration in males at 30, 60, and 120 minutes during the intraperitoneal glucose tolerance test

Allelic Composition	Dbsq3^C3H/HeJ/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺
Genetic Background	involves: C3H/HeJ * C57BLKS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbsq3^C3H/HeJ mutation (0 available); any Dbsq3 mutation (0 available)
Lepr^db mutation (18 available); any Lepr mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:116038 )

• increased blood glucose concentration in males at 30, 60, and 120 minutes during the intraperitoneal glucose tolerance test

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