Lepr^tm1.1Rll
Targeted Allele Detail

Summary

• Symbol: Lepr^tm1.1Rll
• Name: leptin receptor; targeted mutation 1.1, Rudolph L Leibel
• MGI ID: MGI:5049781
• Synonyms: Lepr^223R, Lepr^R
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm1.1Rll page

Increased susceptibility to E. histolytica infection in Lepr^tm1.1Rll/Lepr^tm1.1Rll mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173593
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P3/J

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified exon 4 in which nucleotide substitutions (CAG to CGA) result in the amino acid substitution of arginine for glutamine at position 223 (Q223R). This mutation humanizes the protein. An floxed neo cassette inserted downstream of the modified exon was removed by cre-mediated recombination. (J:173593)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:173593 Stratigopoulos G, et al., Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring). 2009 Jan;17(1):126-35
• All: 4 reference(s)