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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprtm1.1Rll
targeted mutation 1.1, Rudolph L Leibel
MGI:5049781
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Leprtm1.1Rll/Leprtm1.1Rll 129-Leprtm1.1Rll MGI:5049858
hm2
 		Leprtm1.1Rll/Leprtm1.1Rll 129P3/J-Leprtm1.1Rll MGI:5049864
ht3
 		Leprtm1.1Rll/Lepr+ 129P3/J-Leprtm1.1Rll MGI:5049865


Genotype
MGI:5049858
hm1
Allelic
Composition		 Leprtm1.1Rll/Leprtm1.1Rll
Genetic
Background		 129-Leprtm1.1Rll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rll mutation (0 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:173593 )
N
• whether fed standard chow or a high-fat diet, mice exhibit normal weight and composition

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:173593 )
N
• whether fed standard chow or a high-fat diet, mice exhibit normal energy expenditure




Genotype
MGI:5049864
hm2
Allelic
Composition		 Leprtm1.1Rll/Leprtm1.1Rll
Genetic
Background		 129P3/J-Leprtm1.1Rll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rll mutation (0 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased susceptibility to E. histolytica infection in Leprtm1.1Rll/Leprtm1.1Rll mice

immune system
increased susceptibility to parasitic infection ( J:172012 )
• E. histolytica-infected mice exhibit increased infection, more severe epithelial ulceration, and greater intestinal epithelial cell apoptosis compared to in similarly treated wild-type mice

digestive/alimentary system
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice

cellular
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice




Genotype
MGI:5049865
ht3
Allelic
Composition		 Leprtm1.1Rll/Lepr+
Genetic
Background		 129P3/J-Leprtm1.1Rll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Rll mutation (0 available); any Lepr mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:172012 )
• E. histolytica-infected mice exhibit increased infection, more severe epithelial ulceration, and greater intestinal epithelial cell apoptosis compared to in similarly treated wild-type mice

digestive/alimentary system
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice

cellular
increased enterocyte apoptosis ( J:172012 )
• in E. histolytica-infected mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory