Lepr^m6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lepr^m6Btlr
• Name: leptin receptor; mutation 6, Bruce Beutler
• MGI ID: MGI:5609704
• Synonyms: paleo
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^m6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a T to A transversion at base pair 101,745,645 (v38) on chromosome 4, or base pair 28,239 in GenBank genomic region NC_000070; this corresponds to nucleotide 1,181 in the mRNA sequence NM_146146, within exon 5 of 19 total exons. The mutation results in a methionine (M) to lysine (K) substitution at amino acid position 210 (M210K) of the protein. (J:216794)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:216794 SoRelle J, et al., Mutagenetix entry for paleo. Updated January 09, 2015. MGI Direct Data Submission. 2015
• All: 1 reference(s)