About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprm6Btlr
mutation 6, Bruce Beutler
MGI:5609704
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Leprm6Btlr/Leprm6Btlr C57BL/6J-Leprm6Btlr MGI:5609706
ht2
 		Leprm6Btlr/Lepr+ C57BL/6J-Leprm6Btlr MGI:5609711


Genotype
MGI:5609706
hm1
Allelic
Composition		 Leprm6Btlr/Leprm6Btlr
Genetic
Background		 C57BL/6J-Leprm6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprm6Btlr mutation (0 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:216794 )
• mice homozygous for this mutation exhibit a significant increase in body weight compared to wild-type mice.




Genotype
MGI:5609711
ht2
Allelic
Composition		 Leprm6Btlr/Lepr+
Genetic
Background		 C57BL/6J-Leprm6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprm6Btlr mutation (0 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:216794 )
• mice heterozygous for this mutation exhibit a significantly increased body weight, intermediate between those of homozyous mutant and and wild-type mice, but not significant enough to consider the allele semidominant.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory