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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkdc+
wild type
MGI:2433282
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		PrkdcM10Btlr/Prkdc+ C57BL/6J-PrkdcM10Btlr MGI:6114648
ht2
 		PrkdcM11Btlr/Prkdc+ C57BL/6J-PrkdcM11Btlr MGI:6114655
ht3
 		PrkdcM8Btlr/Prkdc+ C57BL/6J-PrkdcM8Btlr MGI:6114158
ht4
 		PrkdcM9Btlr/Prkdc+ C57BL/6J-PrkdcM9Btlr MGI:6114642
ht5
 		Prkdctm1.1Bpcc/Prkdc+ involves: 129 * C57BL/6 MGI:4950419
cx6
 		Prkdctm1Get/Prkdc+
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3040060
cx7
 		Prkdcscid/Prkdc+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6J MGI:2665138
cx8
 		Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0 		involves: C57BL/6J * DBA/2J MGI:2665137


Genotype
MGI:6114648
ht1
Allelic
Composition		 PrkdcM10Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM10Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM10Btlr mutation (0 available); any Prkdc mutation (420 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:6114655
ht2
Allelic
Composition		 PrkdcM11Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM11Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM11Btlr mutation (0 available); any Prkdc mutation (420 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
enhanced humoral immune response ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:6114158
ht3
Allelic
Composition		 PrkdcM8Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM8Btlr mutation (0 available); any Prkdc mutation (420 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection

immune system
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection




Genotype
MGI:6114642
ht4
Allelic
Composition		 PrkdcM9Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM9Btlr mutation (0 available); any Prkdc mutation (420 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection

hematopoietic system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection




Genotype
MGI:4950419
ht5
Allelic
Composition		 Prkdctm1.1Bpcc/Prkdc+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdctm1.1Bpcc mutation (0 available); any Prkdc mutation (420 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
hyperpigmentation ( J:171351 )
• mild hyperpigmentation of the footpad in mice over 2 months of age




Genotype
MGI:3040060
cx6
Allelic
Composition		 Prkdctm1Get/Prkdc+
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdctm1Get mutation (3 available); any Prkdc mutation (420 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:84801 )
• end to end chromosome fusions occur in about 1.6 out of 100 metaphases
• chromosome fusions involve random chromosomes
decreased telomere length ( J:84801 )
• telomeres are significantly shorter than in doubly heterozygous controls but there is always a detectable telomere




Genotype
MGI:2665138
cx7
Allelic
Composition		 Prkdcscid/Prkdc+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (180 available); any Prkdc mutation (420 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 183 days

neoplasm
increased thymoma incidence ( J:47667 )
• 60% incidence of thymoma




Genotype
MGI:2665137
cx8
Allelic
Composition		 Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (180 available); any Prkdc mutation (420 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 183 days

neoplasm
increased thymoma incidence ( J:47667 )
• 93% incidence of thymoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory