Prkdc^M8Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkdc^M8Btlr
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 8, Bruce Beutler
• MGI ID: MGI:6114155
• Synonyms: Screamer7
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^M8Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 15,654,817 (v38) on chromosome 16, or base pair 17,364 in the GenBank genomic region NC_000082 within the splice acceptor site on intron 8. The effect of the mutation at the cDNA and protein levels have not examined, but the mutation is predicted to result in the use of a cryptic splice site in intron 8. The resulting transcript would have a 3-base pair insertion of intron 8, leading to an in-frame protein product beginning after amino acid 259 in encoded protein, which is normally 4,128 amino acids long. (J:255224)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 408 strains or lines available

References

• Original: J:255224 Yue T, et al., Mutagenetix entry for screamer7. MGI Direct Data Submission. 2018
• All: 1 reference(s)