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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkdcM8Btlr
mutation 8, Bruce Beutler
MGI:6114155
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkdcM8Btlr/PrkdcM8Btlr C57BL/6J-PrkdcM8Btlr MGI:6114157
ht2
 		PrkdcM8Btlr/Prkdc+ C57BL/6J-PrkdcM8Btlr MGI:6114158


Genotype
MGI:6114157
hm1
Allelic
Composition		 PrkdcM8Btlr/PrkdcM8Btlr
Genetic
Background		 C57BL/6J-PrkdcM8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM8Btlr mutation (0 available); any Prkdc mutation (399 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased plasmacytoid dendritic cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection

hematopoietic system
increased plasmacytoid dendritic cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection




Genotype
MGI:6114158
ht2
Allelic
Composition		 PrkdcM8Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM8Btlr mutation (0 available); any Prkdc mutation (399 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection

immune system
decreased CD8-positive, alpha-beta T cell number ( J:255224 )
• in the peripheral blood after mouse cytomegalovirus (MCMV) infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory