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Targeted Allele Detail
Symbol: Rad54ltm1Jhjh
Name: RAD54 like (S. cerevisiae); targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:2183934
Synonyms: mRAD54-, mRAD54307neo
Gene: Rad54l  Location: Chr4:115951461-115980887 bp, - strand  Genetic Position: Chr4, 53.1 cM
Alliance: Rad54ltm1Jhjh page
Germline Transmission:  Earliest citation of germline transmission: J:39642
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 4, upstream of approximately 90% of the protein product including the conserved motifs involved in ATPase activity. Sequence analysis showed that excision of the disrupted exon would result in a frameshift mutation. The absence of transcript and protein was determined by Northern and Western blot analysis. (J:39642)
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Rad54ltm1Jhjh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad54l Mutation:  46 strains or lines available
Original:  J:39642 Essers J, et al., Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell. 1997 Apr 18;89(2):195-204
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
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