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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox4+
wild type
MGI:2431978
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sox4em1(IMPC)Mbp/Sox4+ C57BL/6NCrl-Sox4em1(IMPC)Mbp/MbpMmucd MGI:7415085
ht2
 		Sox4tm1.1Vlf/Sox4+ involves: 129 * C57BL/6 * FVB/N MGI:5285370
ht3
 		Sox4M91Ark/Sox4+ involves: C3H/HeH MGI:3819948
ht4
 		Sox4Igt4/Sox4+ involves: C3H/HeH * C57BL/6 MGI:3819942
cx5
 		Foxq1sa/Foxq1+
Sox4M91Ark/Del(13)36H 		involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR MGI:3819858
cx6
 		Foxq1sa/Foxq1+
Sox4M91Ark/Sox4+ 		involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR MGI:5516058
cx7
 		Sox4Igt4/Del(13)36H involves: 101/H * C3H/HeH * C57BL/6 MGI:3819947
cx8
 		Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk 		involves: 129 * C57BL/6 * CBA * FVB/N MGI:5285372
cx9
 		Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1.1Vlf/Sox4+ 		involves: 129 * C57BL/6 * FVB/N MGI:5285378
cx10
 		Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+ 		involves: 129 * C57BL/6 * FVB/N MGI:5285373
cx11
 		Sox11tm1.2Vlf/Sox11+
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285380
cx12
 		Insrtm1Dac/Insr+
Sox4Igt4/Sox4+ 		involves: C3H/HeH * C57BL/6 MGI:3819939


Genotype
MGI:7415085
ht1
Allelic
Composition		 Sox4em1(IMPC)Mbp/Sox4+
Genetic
Background		 C57BL/6NCrl-Sox4em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4em1(IMPC)Mbp mutation (1 available); any Sox4 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

endocrine/exocrine glands

growth/size/body
enlarged gallbladder ( J:211773 )
IMPC - UCD
decreased body length ( J:211773 )
IMPC - UCD

homeostasis/metabolism

liver/biliary system

nervous system

reproductive system
enlarged uterus ( J:211773 )
IMPC - UCD

skeleton

vision/eye




Genotype
MGI:5285370
ht2
Allelic
Composition		 Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system




Genotype
MGI:3819948
ht3
Allelic
Composition		 Sox4M91Ark/Sox4+
Genetic
Background		 involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4M91Ark mutation (2 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose

homeostasis/metabolism
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose
decreased circulating insulin level ( J:141688 )
• circulating insulin levels are significantly lower 10 to 30 minutes after a glucose challenge
impaired glucose tolerance ( J:141688 )
• these mice have impaired glucose tolerance with glucose levels significantly higher 60 minutes after glucose administration




Genotype
MGI:3819942
ht4
Allelic
Composition		 Sox4Igt4/Sox4+
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4Igt4 mutation (1 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose
decreased circulating insulin level ( J:141688 )
• circulating insulin levels are significantly lower 10 to 30 minutes after a glucose challenge
impaired glucose tolerance ( J:141688 )
• these mice have impaired glucose tolerance with glucose levels significantly higher 60 minutes after glucose administration

endocrine/exocrine glands
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose




Genotype
MGI:3819858
cx5
Allelic
Composition		 Foxq1sa/Foxq1+
Sox4M91Ark/Del(13)36H
Genetic
Background		 involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1sa mutation (16 available); any Foxq1 mutation (30 available)
Sox4M91Ark mutation (2 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:101156 )
• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system
abnormal aortic arch morphology ( J:101156 )
• smaller than the pulmonary artery
abnormal cardiovascular development ( J:101156 )
• circulatory failure
abnormal heart development ( J:101156 )
• common atrioventricular junction
double outlet right ventricle ( J:101156 )
• the aorta and pulmonary artery both originate from the right ventricle
abnormal mitral valve morphology ( J:101156 )
• the mitral valve of E14.5 embryos is dysplastic
ostium primum atrial septal defect ( J:101156 )
• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos
ventricular septal defect ( J:101156 )
• a large ventricular septum defect connects the left and right ventricles

renal/urinary system
abnormal kidney development ( J:101156 )
• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

nervous system




Genotype
MGI:5516058
cx6
Allelic
Composition		 Foxq1sa/Foxq1+
Sox4M91Ark/Sox4+
Genetic
Background		 involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1sa mutation (16 available); any Foxq1 mutation (30 available)
Sox4M91Ark mutation (2 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased anxiety-related response ( J:101156 )
• mice have a 31% decrease compared to controls in how many times the central portion of an open field test is entered
• mice also have additional reductions in total distance traveled (22% decrease) and movement time (14% decrease) in the open field tests




Genotype
MGI:3819947
cx7
Allelic
Composition		 Sox4Igt4/Del(13)36H
Genetic
Background		 involves: 101/H * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Sox4Igt4 mutation (1 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
interrupted aortic arch ( J:141688 )
• hypoplastic or interrupted aortic arches are observed in E14.5 fetuses
double outlet right ventricle ( J:141688 )
• the aorta and pulmonary artery both originate from the right ventricle
abnormal atrioventricular valve morphology ( J:141688 )
• the atrioventricular valves of E14.5 embryos are dysplastic
subarterial ventricular septal defect ( J:141688 )
• a large outlet ventricular septum defect connects the left and right ventricles

craniofacial
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate

digestive/alimentary system
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate

hematopoietic system
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

homeostasis/metabolism
extremity edema ( J:141688 )
• severe edema is observed in the extremities of the E14.5 fetus

immune system
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

renal/urinary system
renal hypoplasia ( J:141688 )
• bilateral renal hypoplasia is noted in one case

endocrine/exocrine glands
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

growth/size/body
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate




Genotype
MGI:5285372
cx8
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
double outlet right ventricle ( J:175338 )
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
ventricular septal defect ( J:175338 )
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes

embryo
abnormal notochord morphology ( J:175338 )
• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton
abnormal vertebrae morphology ( J:175338 )
• more severe and more frequent than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes




Genotype
MGI:5285378
cx9
Allelic
Composition		 Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
myocardium hypoplasia ( J:175338 )
• hypoplastic myocardium
semilunar valve hypoplasia ( J:175338 )
• hypoplastic semilunar valves

skeleton
micrognathia ( J:175338 )
• at E17.5
sternum hypoplasia ( J:175338 )
• at E17.5

vision/eye
aphakia ( J:175338 )
• at E17.5
abnormal eye development ( J:175338 )
• underdeveloped
microphthalmia ( J:175338 )
• at E17.5

respiratory system
abnormal lung development ( J:175338 )
• underdeveloped
small lung ( J:175338 )
• at E17.5

craniofacial
micrognathia ( J:175338 )
• at E17.5

homeostasis/metabolism
edema ( J:175338 )
• generalized at E17.5

muscle
myocardium hypoplasia ( J:175338 )
• hypoplastic myocardium

growth/size/body
micrognathia ( J:175338 )
• at E17.5




Genotype
MGI:5285373
cx10
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal cranium morphology ( J:175338 )
• hypomineralized skull with wide sutures
abnormal sternebra morphology ( J:175338 )
• hypoplastic
• the last two or three sternebrae are misshapen and irregularly mineralized
abnormal xiphoid process morphology ( J:175338 )
• the xiphoid process is misshapen and irregularly mineralized
abnormal lumbar vertebrae morphology ( J:175338 )
• unfused lumbar vertebral bodies
• L4 and L5 are duplicated
abnormal bone mineralization ( J:175338 )
• hypomineralized skull
• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system
ventricular septal defect ( J:175338 )
• incomplete ventricular septation

vision/eye
vision/eye phenotype ( J:175338 )
N
• mice exhibit normal eyes

craniofacial
craniofacial phenotype ( J:175338 )
N
• mice exhibit normal palate and lip formation
abnormal cranium morphology ( J:175338 )
• hypomineralized skull with wide sutures

hematopoietic system
small spleen ( J:175338 )
• in 60% of mice

immune system
small spleen ( J:175338 )
• in 60% of mice

growth/size/body
omphalocele ( J:175338 )
• in 50% of mice in one of 2 crosses




Genotype
MGI:5285380
cx11
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (11 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular septal defect ( J:175338 )
• incomplete ventricular septation

skeleton
abnormal cranium morphology ( J:175338 )
• hypomineralized skull
abnormal sternebra morphology ( J:175338 )
• fusion and /or deletion
• split sternal bars in all mice
abnormal vertebrae morphology ( J:175338 )
• vertebral body duplication in all mice
abnormal bone mineralization ( J:175338 )
• hypomineralized skull

craniofacial
abnormal cranium morphology ( J:175338 )
• hypomineralized skull

immune system
small spleen ( J:175338 )
• in all mice

hematopoietic system
small spleen ( J:175338 )
• in all mice




Genotype
MGI:3819939
cx12
Allelic
Composition		 Insrtm1Dac/Insr+
Sox4Igt4/Sox4+
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Sox4Igt4 mutation (1 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:141688 )
• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration
• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr




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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory