Phenotypes associated with this allele

• Allele Symbol: Pdgfra⁺
• Allele Name: wild type
• Allele ID: MGI:2431667
• Summary: 25 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pdgfra^em1(IMPC)Ccpcz/Pdgfra^+	C57BL/6NCrl-Pdgfra^em1(IMPC)Ccpcz/Ccpcz	MGI:8176257
ht2	Pdgfra^tm1Sor/Pdgfra^+	either: 129S4/SvJaeSor-Pdgfra^tm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3655071
ht3	Pdgfra^tm2Sor/Pdgfra^+	either: 129S4/SvJaeSor-Pdgfra^tm2Sor or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3655105
ht4	Pdgfra^tm9(Pdgfra/Fgfr1)Sor/Pdgfra^+	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663640
ht5	Pdgfra^tm12.1Sor/Pdgfra^+	involves: 129 * C57BL/6	MGI:3838617
ht6	Pdgfra^tm13.1Sor/Pdgfra^+	involves: 129 * C57BL/6	MGI:3838618
ht7	Pdgfra^tm1.1(EGFP/cre/ERT2)Hyma/Pdgfra^+	involves: C57BL/6 * CBA/JNCrlj	MGI:5644438
cn8	Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+ Pdgfra^tm12Sor/Pdgfra^+	involves: 129 * C57BL/6	MGI:3838615
cn9	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+ Pdgfra^tm12Sor/Pdgfra^+	involves: 129 * C57BL/6J * SJL	MGI:3838621
cn10	Pdgfra^tm1.1(cre/Esr1*)Nshk/Pdgfra^+ Runx1^tm1Medv/Runx1^tm1Medv	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5490465
cn11	Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+ Pdgfra^tm13Sor/Pdgfra^+	involves: 129S4/SvJaeSor * C57BL/6	MGI:3838616
cx12	Pdgfra^tm1Sor/Pdgfra^+ Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823001
cx13	2610005L07Rik^Gt(ROSA)73Sor/2610005L07Rik^Gt(ROSA)73Sor Pdgfra^tm1Sor/Pdgfra^+	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823024
cx14	Pdgfra^tm1Sor/Pdgfra^+ Schip1^Gt(ROSA)77Sor/Schip1^Gt(ROSA)77Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823020
cx15	Pdgfra^tm1Sor/Pdgfra^+ Sgpl1^Gt(ROSA)78Sor/Sgpl1^Gt(ROSA)78Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823017
cx16	Pdgfra^tm1Sor/Pdgfra^+ Plekha1^Gt(ROSA)82Sor/Plekha1^Gt(ROSA)82Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3822917
cx17	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:5780588
cx18	Pdgfa^tm1Cbet/Pdgfa^tm2Cbet Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5548177
cx19	2610005L07Rik^Gt(ROSA)73Sor/2610005L07Rik^Gt(ROSA)73Sor Pdgfra^tm2Sor/Pdgfra^+	involves: 129S4/SvJaeSor	MGI:3717137
cx20	Myo1e^Gt(ROSA)74Sor/Myo1e^Gt(ROSA)74Sor Pdgfra^tm2Sor/Pdgfra^+	involves: 129S4/SvJaeSor	MGI:3717131
cx21	Arid5b^Gt(ROSA)75Sor/Arid5b^Gt(ROSA)75Sor Pdgfra^tm2Sor/Pdgfra^+	involves: 129S4/SvJaeSor	MGI:3717132
cx22	Pdgfra^tm2Sor/Pdgfra^+ Tiparp^Gt(ROSA)79Sor/Tiparp^Gt(ROSA)79Sor	involves: 129S4/SvJaeSor	MGI:3717135
cx23	Zfp950^Gt(ROSA)76Sor/Zfp950^Gt(ROSA)76Sor Pdgfra^tm2Sor/Pdgfra^+	involves: 129S4/SvJaeSor	MGI:3717136
cx24	Pdgfra^tm2Sor/Pdgfra^+ Plekha1^Gt(ROSA)82Sor/Plekha1^Gt(ROSA)82Sor	involves: 129S4/SvJaeSor	MGI:3717138
cx25	Hoxa5^tm1Rob/Hoxa5^tm1Rob Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1	MGI:4941631

Genotype
MGI:8176257

ht1

• Allelic Composition: Pdgfra^{em1(IMPC)Ccpcz}/Pdgfra⁺
• Genetic Background: C57BL/6NCrl-Pdgfra^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Pdgfra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

♂

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged kidney ( J:211773 )

♂

IMPC - CCP-IMG

increased kidney weight ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

increased NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased CD4-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

increased NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased CD4-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - CCP-IMG

abnormal lymph node morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged lymph nodes ( J:211773 )

♂

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - CCP-IMG

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged kidney ( J:211773 )

♂

IMPC - CCP-IMG

increased kidney weight ( J:211773 )

♂

IMPC - CCP-IMG

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

respiratory system

increased airway resistance ( J:211773 )

♀

IMPC - CCP-IMG

Genotype
MGI:3655071

ht2

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺
• Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

pigmentation

pigmentation phenotype ( J:41814 )

N • heterozygotes display absence of a pigmentation defect, indicating normal melanocyte migration

Genotype
MGI:3655105

ht3

• Allelic Composition: Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm2Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

pigmentation

pigmentation phenotype ( J:41814 )

N • heterozygotes display absence of a pigmentation defect, indicating normal melanocyte migration

Genotype
MGI:2663640

ht4

• Allelic Composition: Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra⁺
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

craniofacial

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

cleft palate ( J:83560 )

embryo

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

enlarged placenta ( J:83560 )

• large placenta

abnormal trophoblast layer morphology ( J:83560 )

• trophoblast lineages are disorganized, as indicated by an expansion of the chorioallantoic layer into the surrounding labyrinth trophoblast layer

limbs/digits/tail

polydactyly ( J:83560 )

skeleton

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

abnormal pubis morphology ( J:83560 )

• ectopic bone growth extending from the pubic bone and fusing, in most cases, to the elbow

rib fusion ( J:83560 )

nervous system

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

digestive/alimentary system

cleft palate ( J:83560 )

growth/size/body

cleft palate ( J:83560 )

Genotype
MGI:3838617

ht5

• Allelic Composition: Pdgfra^tm12.1Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

postnatal lethality, complete penetrance ( J:146617 )

• while mice are present in Mendelian ratios at E18.5, no mice are present at P14

renal/urinary system

abnormal kidney pelvis morphology ( J:146617 )

• as early as E16.5, the renal pelvis is enlarged unlike in wild-type mice

abnormal ureter morphology ( J:146617 )

• mice exhibit stromal cell hyperplasia in the ureter unlike in wild-type mice

abnormal ureter development ( J:146617 )

• at E13.5, more mesenchymal cells are found in the ureters compared to in wild-type mice likely due to increased migration

• however, cell proliferation in ureters is normal at E13.5

abnormal ureter smooth muscle morphology ( J:146617 )

• ureters exhibit poorly condensed smooth muscle cells unlike in wild-type mice

ureter obstruction ( J:146617 )

• due to stromal cell hyperplasia

respiratory system

pulmonary hyperplasia ( J:146617 )

• at E18.5

abnormal lung development ( J:146617 )

• at E18.5, mice exhibit a failure of terminal sac morphogenesis with lung development only reaching the canalicular stage

increased mesenchymal cell proliferation involved in lung development ( J:146617 )

• at E18.5, mice exhibit 1.6-fold increase in mesenchymal cell density

digestive/alimentary system

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

abnormal stomach morphology ( J:146617 )

• mice exhibit hyperplasia of stromal cells in the stomach compared to in wild-type mice

cellular

increased fibroblast chemotaxis ( J:146617 )

• in culture, fibroblasts exhibit increased migration towards PDGF-AA compared to wild-type cells

increased cell proliferation ( J:146617 )

• at E13.5, esophageal cells exhibit increased proliferation compared to in wild-type mice

• however, cell proliferation in ureters is normal at E13.5

increased fibroblast proliferation ( J:146617 )

• in culture, primary fibroblasts exhibit increased growth potential compared to wild-type cells

increased mesenchymal cell proliferation involved in lung development ( J:146617 )

• at E18.5, mice exhibit 1.6-fold increase in mesenchymal cell density

growth/size/body

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

increased embryo size ( J:146617 )

• from E12.5 to E16.5

increased fetal size ( J:146617 )

• from E12.5 to E16.5

pulmonary hyperplasia ( J:146617 )

• at E18.5

skeleton

abnormal sternum morphology ( J:146617 )

• at E18.5, mice have a wide, unsegmented sternum unlike in wild-type mice

• sternal bands are unfused

wide sternum ( J:146617 )

• at E18.5

abnormal rib morphology ( J:146617 )

• ribs exhibit incomplete contact

embryo

increased embryo size ( J:146617 )

• from E12.5 to E16.5

abnormal mesenchyme morphology ( J:146617 )

• embryos exhibit uncondensed mesenchyme

immune system

abnormal immune system organ morphology ( J:146617 )

• lymphatic structures are enlarged during late fetal development

homeostasis/metabolism

edema ( J:146617 )

• in the torso in embryos

Genotype
MGI:3838618

ht6

• Allelic Composition: Pdgfra^tm13.1Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:146617 )

• while mice are present in Mendelian ratios at E18.5, fewer than expected mice are present at P14

renal/urinary system

abnormal kidney pelvis morphology ( J:146617 )

• as early as E16.5 the renal pelvis is enlarged unlike in wild-type mice

hydronephrosis ( J:146617 )

• mice develop bilateral hydronephrosis unlike in wild-type mice

abnormal ureter morphology ( J:146617 )

• mice exhibit stromal hyperplasia in the ureter unlike in wild-type mice

abnormal ureter smooth muscle morphology ( J:146617 )

• ureters exhibit poorly condensed smooth muscle cells unlike in wild-type mice

dilated ureter ( J:146617 )

ureter obstruction ( J:146617 )

• due to stromal cell hyperplasia

digestive/alimentary system

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

abnormal stomach morphology ( J:146617 )

• mice exhibit hyperplasia of stromal cells in the stomach

cellular

increased fibroblast proliferation ( J:146617 )

• in culture, primary fibroblasts exhibit increased growth potential compared to wild-type cells

growth/size/body

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

Genotype
MGI:5644438

ht7

• Allelic Composition: Pdgfra^{tm1.1(EGFP/cre/ERT2)Hyma}/Pdgfra⁺
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj

cellular

cellular phenotype ( J:221424 )

N • mouse embryonic fibroblasts exhibit normal proliferation

growth/size/body

growth/size/body region phenotype ( J:221424 )

N • 8 week old weight is normal

Genotype
MGI:3838615

cn8

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Pdgfra^tm12Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

premature death ( J:146617 )

• 6 months after tamoxifen treatment, mice develop intestinal disease and eventually die or are sacrificed

digestive/alimentary system

abnormal cecum morphology ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

abnormal small intestine morphology ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

intestinal fibrosis ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

intestine polyps ( J:146617 )

• in tamoxifen-treated mice

cardiovascular system

cardiac fibrosis ( J:146617 )

• in tamoxifen-treated mice

renal/urinary system

glomerulosclerosis ( J:146617 )

• sclerotic glomeruli in tamoxifen-treated mice

renal glomerulus fibrosis ( J:146617 )

• in tamoxifen-treated mice

renal glomerulus hypertrophy ( J:146617 )

• enlarged glomeruli in tamoxifen-treated mice

renal interstitial fibrosis ( J:146617 )

• in tamoxifen-treated mice

neoplasm

increased sarcoma incidence ( J:146617 )

• at between 44 and 76 weeks of age, 5 of 29 tamoxifen-treated mice develop sarcomas arising from dermis or muscle connective tissue

muscle

skeletal muscle interstitial fibrosis ( J:146617 )

• in tamoxifen-treated mice

respiratory system

pulmonary fibrosis ( J:146617 )

• around the bronchioles in tamoxifen-treated mice

integument

tight skin ( J:146617 )

• in tamoxifen-treated mice

Genotype
MGI:3838621

cn9

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Pdgfra^tm12Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6J * SJL

neoplasm

increased sarcoma incidence ( J:146617 )

• all tamoxifen-treated mice develop sarcomas of the skin or muscle connective tissue after 10 to 19 weeks

increased fibrosarcoma incidence ( J:146617 )

• 2 tamoxifen-treated mice develop large intestinal tumors resembling undifferentiated fibrosarcomas

muscle

skeletal muscle interstitial fibrosis ( J:146617 )

• tamoxifen-treated mice develop muscle fibrosis at 10 to 19 weeks of age

integument

skin fibrosis ( J:146617 )

• tamoxifen-treated mice develop skin fibrosis at 10 to 19 weeks of age

digestive/alimentary system

intestinal fibrosis ( J:146617 )

• after 15 weeks, tamoxifen-treated mice exhibit intestinal fibrosis

Genotype
MGI:5490465

cn10

• Allelic Composition: Pdgfra^{tm1.1(cre/Esr1*)Nshk}/Pdgfra⁺; Runx1^tm1Medv/Runx1^tm1Medv
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) do not survive beyond E12.5

hematopoietic system

anemia ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) are modestly anemic

abnormal hematopoietic cell number ( J:193389 )

• with tamoxifen treatment at E7.5, Runx1 expression is restored in the Pdgfra+ve mesoderm and this partially restores CD45+ve and Lin-Kit-Sca1+ve (KSL) hematopoietic cells (HPCs) in the fetal liver at E12.5; these populations are absent without tamoxifen treatment

• with tamoxifen treatment at E7.5, partial recovery of colony forming units (CFUs) from liver cells grown on methycellulose is observed, but without tamoxifen, fetal liver cells fail to generate colonies

integument

pallor ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) are pale

Genotype
MGI:3838616

cn11

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Pdgfra^tm13Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

digestive/alimentary system

intestinal fibrosis ( J:146617 )

• 4 of 9 tamoxifen-treated mice exhibit intestinal fibrosis

intestine polyps ( J:146617 )

• in one tamoxifen-treated mouse

renal/urinary system

glomerulosclerosis ( J:146617 )

• sclerotic glomeruli in tamoxifen-treated mice

renal glomerulus hypertrophy ( J:146617 )

• enlarged glomeruli in tamoxifen-treated mice

cardiovascular system

cardiac fibrosis ( J:146617 )

• in tamoxifen-treated mice

muscle

skeletal muscle interstitial fibrosis ( J:146617 )

• in tamoxifen-treated mice

integument

tight skin ( J:146617 )

• in some tamoxifen-treated mice

Genotype
MGI:3823001

cx12

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺; Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

female infertility ( J:142042 )

♀

Genotype
MGI:3823024

cx13

• Allelic Composition: 2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}; Pdgfra^tm1Sor/Pdgfra⁺
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

uterus hypoplasia ( J:142042 )

♀ • uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

♀ • little or no ovulation

female infertility ( J:142042 )

♀ • 35% of females are sterile

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Genotype
MGI:3823020

cx14

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺; Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

uterus hypoplasia ( J:142042 )

♀ • uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

♀ • little or no ovulation

female infertility ( J:142042 )

♀ • 45% of females are sterile

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Genotype
MGI:3823017

cx15

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺; Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

female infertility ( J:142042 )

♀

male infertility ( J:142042 )

♂

Genotype
MGI:3822917

cx16

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺; Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

♀

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

uterus hypoplasia ( J:142042 )

♀ • uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

♀ • little or no ovulation

female infertility ( J:142042 )

♀ • 71% of females are sterile

male infertility ( J:142042 )

♂

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

♀

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Genotype
MGI:5780588

cx17

• Allelic Composition: Gata6^tm2.2Sad/Gata6^tm2.2Sad; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

embryo

absent primitive endoderm ( J:213580 )

Genotype
MGI:5548177

cx18

• Allelic Composition: Pdgfa^tm1Cbet/Pdgfa^tm2Cbet; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

respiratory system

abnormal lung morphology ( J:205009 )

• progressive dilated distal airway

abnormal pulmonary alveolus morphology ( J:205009 )

• progressive loss

emphysema ( J:205009 )

• at 3 months

digestive/alimentary system

digestive/alimentary phenotype ( J:205009 )

N • mice exhibit normal gastrointestinal tract

renal/urinary system

renal/urinary system phenotype ( J:205009 )

N • mice exhibit normal kidneys

skeleton

skeleton phenotype ( J:205009 )

N • mice exhibit normal skeleton

Genotype
MGI:3717137

cx19

• Allelic Composition: 2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}; Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

Genotype
MGI:3717131

cx20

• Allelic Composition: Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor}; Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor

hematopoietic system

anemia ( J:117491 )

• anemia is less severe than in Myo1e^{Gt(ROSA)74Sor} homozygotes

Genotype
MGI:3717132

cx21

• Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}; Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Arid5b^{Gt(ROSA)75Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Arid5b^{Gt(ROSA)75Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Arid5b^{Gt(ROSA)75Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

digestive/alimentary system

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Arid5b^{Gt(ROSA)75Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

Genotype
MGI:3717135

cx22

• Allelic Composition: Pdgfra^tm2Sor/Pdgfra⁺; Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
• Genetic Background: involves: 129S4/SvJaeSor

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Tiparp^{Gt(ROSA)79Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Tiparp^{Gt(ROSA)79Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Tiparp^{Gt(ROSA)79Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Tiparp^{Gt(ROSA)79Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

Genotype
MGI:3717136

cx23

• Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor}; Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in 5830428H23Rik ^{Gt(ROSA)76Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

Genotype
MGI:3717138

cx24

• Allelic Composition: Pdgfra^tm2Sor/Pdgfra⁺; Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
• Genetic Background: involves: 129S4/SvJaeSor

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Plekha1^{Gt(ROSA)82Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

midline facial cleft ( J:117491 )

• 2 of 7 mice have clefts that extend through the cartilaginous nasal capsule, palate and frontal bones

digestive/alimentary system

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

skeleton

abnormal skeleton morphology ( J:117491 )

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Plekha1^{Gt(ROSA)82Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Plekha1^{Gt(ROSA)82Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

midline facial cleft ( J:117491 )

• 2 of 7 mice have clefts that extend through the cartilaginous nasal capsule, palate and frontal bones

respiratory system

short nasal bone ( J:117491 )

Genotype
MGI:4941631

cx25

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

respiratory system

abnormal pulmonary alveolar parenchyma morphology ( J:113378 )

• at E16.5, most alveolar myofibroblast progenitors fail to spread distally and remain clustered around the epithelium, unlike in wild-type lungs where progenitors are dispersed in the lung parenchyma

• alveolar myofibroblast progenitors also fail to invade some regions of the developing lung

cellular

abnormal cell migration ( J:113378 )

• wounding assays performed on primary mesenchymal cells isolated from E15.5 lungs revealed that, unlike wild-type cells which invade the wounded area within 12 hrs and fill the gap by 24 hrs, mutant cells display reduced migration at both time points

• however, no difference in migratory behavior is observed in response to gelatin in Boyden chambers