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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab8a+
wild type
MGI:2431375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rab8aem1(IMPC)J/Rab8a+ C57BL/6NJ-Rab8aem1(IMPC)J/Mmjax MGI:6263306
cn2
 		Cdc42tm1Brak/Cdc42+
Rab8atm1.1Aha/Rab8a+
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * SJL MGI:5427871


Genotype
MGI:6263306
ht1
Allelic
Composition		 Rab8aem1(IMPC)J/Rab8a+
Genetic
Background		 C57BL/6NJ-Rab8aem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab8aem1(IMPC)J mutation (2 available); any Rab8a mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body
decreased lean body mass ( J:211773 )
IMPC - JAX




Genotype
MGI:5427871
cn2
Allelic
Composition		 Cdc42tm1Brak/Cdc42+
Rab8atm1.1Aha/Rab8a+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation (0 available); any Cdc42 mutation (43 available)
Rab8atm1.1Aha mutation (0 available); any Rab8a mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:184563 )
• greatly expanded or elongated crypts with large lumens and vacuoles
• the inner surfaces of cryptic lumina/values are lined by microvilli
abnormal Paneth cell morphology ( J:184563 )
• electron densities of Paneth cell granules are reduced in crypts
intestinal edema ( J:184563 )
• increase in intestinal tissue weight per surface area, indicating tissue edema
abnormal intestine physiology ( J:184563 )
• mutant intestines exhibit a reduction in glucose uptake compared to either single mutant

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:184563 )
• greatly expanded or elongated crypts with large lumens and vacuoles
• the inner surfaces of cryptic lumina/values are lined by microvilli
abnormal Paneth cell morphology ( J:184563 )
• electron densities of Paneth cell granules are reduced in crypts

homeostasis/metabolism
intestinal edema ( J:184563 )
• increase in intestinal tissue weight per surface area, indicating tissue edema

cellular
abnormal cellular glucose uptake ( J:184563 )
• mutant intestines exhibit a reduction in glucose uptake compared to either single mutant




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory