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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt19+
wild type
MGI:2431156
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Krt19tm1Alki/Krt19+ involves: 129X1/SvJ * C57BL/6J MGI:3760088
cn2
 		Krastm4Tyj/Kras+
Krt19tm1(cre/ERT)Ggu/Krt19+
Ptentm2Mak/Ptentm2Mak 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac MGI:6256734
cn3
 		Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Krt19tm1(cre/ERT)Ggu/Krt19+ 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac MGI:5298083
cn4
 		Sox9tm1Gsr/Sox9tm1Gsr
Krt19tm1(cre)Mmt/Krt19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3639700
cn5
 		Krastm4Tyj/Kras+
Krt19tm1(cre/ERT)Ggu/Krt19+ 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:5298082
cn6
 		Ctnnb1tm1Mmt/Ctnnb1+
Krt19tm1(cre)Mmt/Krt19+ 		involves: 129X1/SvJ MGI:2673257


Genotype
MGI:3760088
ht1
Allelic
Composition		 Krt19tm1Alki/Krt19+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm1Alki mutation (0 available); any Krt19 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatid and epididymal sperm tail abnormalities in Krt19tm1Alki/Krt19tm1Alki and Krt19tm1Alki/Krt19+ mice

reproductive system
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette

cellular
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette




Genotype
MGI:6256734
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Krt19tm1(cre/ERT)Ggu/Krt19+
Ptentm2Mak/Ptentm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Krt19tm1(cre/ERT)Ggu mutation (1 available); any Krt19 mutation (22 available)
Ptentm2Mak mutation (4 available); any Pten mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:254370 )
• mice administered tamoxifen at 8 weeks of age show a median survival of 30 days after tamoxifen injection

digestive/alimentary system
abnormal colon morphology ( J:254370 )
• colonic serrated epithelial changes in tamoxifen treated mice
stomach mucosa hyperplasia ( J:254370 )
• hyperplastic changes of gastric mucosa in tamoxifen treated mice

endocrine/exocrine glands
abnormal extrahepatic bile duct morphology ( J:254370 )
• extrahepatic bile duct is rigid and dilated in tamoxifen treated mice
• papillary hyperplasia of the extrahepatic biliary tract
abnormal gallbladder morphology ( J:254370 )
• papillary hyperplasia of the gallbladder in tamoxifen treated mice
abnormal cystic duct morphology ( J:254370 )
• gallbladder and cystic duct are rigid and dilated in tamoxifen treated mice
dilated gallbladder ( J:254370 )
• in tamoxifen treated mice
increased pancreatic intraepithelial neoplasia incidence ( J:254370 )
• PanIN-like lesions and hyperplasia in the pancreatic ducts in tamoxifen treated mice
• however, no obvious tumors are seen in mice administered tamoxifen at 8 weeks of age

immune system
lung inflammation ( J:254370 )
• obstructive pneumonia in tamoxifen treated mice

liver/biliary system
abnormal extrahepatic bile duct morphology ( J:254370 )
• extrahepatic bile duct is rigid and dilated in tamoxifen treated mice
• papillary hyperplasia of the extrahepatic biliary tract
abnormal gallbladder morphology ( J:254370 )
• papillary hyperplasia of the gallbladder in tamoxifen treated mice
abnormal cystic duct morphology ( J:254370 )
• gallbladder and cystic duct are rigid and dilated in tamoxifen treated mice
dilated gallbladder ( J:254370 )
• in tamoxifen treated mice
abnormal liver morphology ( J:254370 )
• liver of tamoxifen treated mice shows pre-malignant papillary ductal lesions in periportal areas

neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:254370 )
• PanIN-like lesions and hyperplasia in the pancreatic ducts in tamoxifen treated mice
• however, no obvious tumors are seen in mice administered tamoxifen at 8 weeks of age

respiratory system
lung inflammation ( J:254370 )
• obstructive pneumonia in tamoxifen treated mice
bronchial epithelial hyperplasia ( J:254370 )
• papillary hyperplasia of bronchial epithelia in tamoxifen treated mice
respiratory failure ( J:254370 )
• respiratory failure by lung lesions in tamoxifen treated mice




Genotype
MGI:5298083
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Krt19tm1(cre/ERT)Ggu mutation (1 available); any Krt19 mutation (22 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:172048 )
• tamoxifen treated mice die within 2 months from intestinal cancers before developing skin tumors

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:172048 )
• tamoxifen treated mice develop intestinal cancers

neoplasm
increased gastrointestinal tumor incidence ( J:172048 )
• tamoxifen treated mice develop intestinal cancers
increased skin tumor incidence ( J:172048 )
• when back skin from mutant animals is grafted onto back skin of nude mice, all engrafted mice develop skin tumors, including ulcerative lesions (benign and squamous cell carcinomas) within 2 months of tamoxifen administration
increased carcinoma incidence ( J:172048 )
• tamoxifen treated mice develop terminal intestinal carcinomas with 2 months of treatment

integument
increased skin tumor incidence ( J:172048 )
• when back skin from mutant animals is grafted onto back skin of nude mice, all engrafted mice develop skin tumors, including ulcerative lesions (benign and squamous cell carcinomas) within 2 months of tamoxifen administration




Genotype
MGI:3639700
cn4
Allelic
Composition		 Sox9tm1Gsr/Sox9tm1Gsr
Krt19tm1(cre)Mmt/Krt19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm1(cre)Mmt mutation (0 available); any Krt19 mutation (22 available)
Sox9tm1Gsr mutation (2 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:104330 )
• recover only about 1/8 of the expected number of embryos after E11.5, however some survive up to E15.5

reproductive system
abnormal testis development ( J:104330 )
• failure of testis differentiation is apparent at E12.5
absent testis cords ( J:104330 )
• lack of testis cord formation
absent Leydig cells ( J:104330 )
• Leydig cells do not form
primary sex reversal ( J:104330 )
• XY gonads up to E15.5 show immediate complete sex reversal as indicated by the expression of early ovary-specific markers and lack of testis cord and Leydig cell formation
• 2 of 11 embryos form a completely sex-reversed gonad on one side and an ovotestis on the contralateral side

cardiovascular system

skeleton
abnormal cartilage development ( J:104330 )
• display a reduction in all cartilage anlagen

endocrine/exocrine glands
abnormal testis development ( J:104330 )
• failure of testis differentiation is apparent at E12.5
absent testis cords ( J:104330 )
• lack of testis cord formation
absent Leydig cells ( J:104330 )
• Leydig cells do not form

embryo
failure of Mullerian duct regression ( J:104330 )
• absence of Mullerian duct regression in males
impaired cranial neural crest cell differentiation ( J:104330 )
• display a reduction in cranial neural crest cell-derived tissue

nervous system
impaired cranial neural crest cell differentiation ( J:104330 )
• display a reduction in cranial neural crest cell-derived tissue




Genotype
MGI:5298082
cn5
Allelic
Composition		 Krastm4Tyj/Kras+
Krt19tm1(cre/ERT)Ggu/Krt19+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Krt19tm1(cre/ERT)Ggu mutation (1 available); any Krt19 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lip tumor incidence ( J:172048 )
• 2-4 months after tamoxifen treatment, lip tumors develop in 78% of treated mice
increased skin tumor incidence ( J:172048 )
• 2-4 months after tamoxifen treatment, tumors develop in the back skin in 33% of treated mice
increased skin papilloma incidence ( J:172048 )
• skin tumors are benign papillomas with no sign of malignant transformation seen up to 4 months after treatment with tamoxifen

craniofacial
increased lip tumor incidence ( J:172048 )
• 2-4 months after tamoxifen treatment, lip tumors develop in 78% of treated mice

growth/size/body
increased lip tumor incidence ( J:172048 )
• 2-4 months after tamoxifen treatment, lip tumors develop in 78% of treated mice

integument
abnormal skin sebaceous gland morphology ( J:172048 )
• sebaceous cyst formation is observed as result of bulge stem cell proliferation and abnormal hair follicle (HF) differentiation
enlarged sebaceous gland ( J:172048 )
• 1 month after tamoxifen treatment, Kras activation results in the enlargement of the majority of sebaceous glands
increased hair follicle cell proliferation ( J:172048 )
• 1 month after tamoxifen treatment, Kras activation results in transient increase in hair follicle bulge stem cell (SC) proliferation
• hyperproliferative bulge SCs can still undergo terminal differentiation
increased skin tumor incidence ( J:172048 )
• 2-4 months after tamoxifen treatment, tumors develop in the back skin in 33% of treated mice
increased skin papilloma incidence ( J:172048 )
• skin tumors are benign papillomas with no sign of malignant transformation seen up to 4 months after treatment with tamoxifen

endocrine/exocrine glands
abnormal skin sebaceous gland morphology ( J:172048 )
• sebaceous cyst formation is observed as result of bulge stem cell proliferation and abnormal hair follicle (HF) differentiation
enlarged sebaceous gland ( J:172048 )
• 1 month after tamoxifen treatment, Kras activation results in the enlargement of the majority of sebaceous glands

cellular
increased cell proliferation ( J:172048 )
• 1 month after tamoxifen treatment, Kras activation results in transient increase in hair follicle bulge stem cell (SC) proliferation




Genotype
MGI:2673257
cn6
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Krt19tm1(cre)Mmt/Krt19+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (51 available)
Krt19tm1(cre)Mmt mutation (0 available); any Krt19 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:58367 )
• died around 3 months of age of anemia and cachexia

neoplasm
increased intestinal adenoma incidence ( J:58367 )
• more than 3000 intestinal polyps/mouse by 3 weeks of age
• primarily in the duodenum and proximal jejunum
• lower densities in the ileum
• microadenomas in the colon

digestive/alimentary system
increased intestinal adenoma incidence ( J:58367 )
• more than 3000 intestinal polyps/mouse by 3 weeks of age
• primarily in the duodenum and proximal jejunum
• lower densities in the ileum
• microadenomas in the colon




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory