All Phenotypes Ighm<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ighm⁺
wild type
MGI:2431051

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ighm^tm1Cgn/Ighm⁺	involves: 129S2/SvPas * C57BL/6	MGI:3767232
ht2	Ighm^tm1Msn/Ighm⁺	involves: 129S/SvEv	MGI:3815406
ht3	Ighm^tm1Cgn/Ighm⁺	NOD.129S2-Ighm^tm1Cgn	MGI:3623426
cn4	Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf/Ighm⁺ Tg(Fcer2a-cre)5Mbu/0	B6.Cg-Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu	MGI:5755471
cx5	Aicda^tm1Hon/Aicda^tm1Hon Ighm^{tm1.1(IGH-2)Cog}/Ighm⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N	MGI:4437207
cx6	Ighm^tm1Cgn/Ighm⁺ Tgfb1^tm1Doe/Tgfb1^tm1Doe	involves: 129S2/SvPas * C57BL/6 * CF-1	MGI:3622466
cx7	Ighm^tm1Cgn/Ighm⁺ Tg(Igh-6/Igh-V125)2Jwt/0 Tg(Igk-C/Igk-V125)1Jwt/0	NOD.Cg-Ighm^tm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt	MGI:3623596
cx8	Ighm^tm1Cgn/Ighm⁺ Tg(Igh-6/Igh-V281)3Jwt/0	NOD.Cg-Ighm^tm1Cgn Tg(Igh-6/Igh-V281)3Jwt	MGI:3623593

Allelic Composition	Ighm^tm1Cgn/Ighm⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:70398 )

• B cell development is arrested at the stage of pre-B cells

immune system

arrested B cell differentiation ( J:70398 )

• B cell development is arrested at the stage of pre-B cells

Allelic Composition	Ighm^tm1Msn/Ighm⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Msn mutation (0 available); any Ighm mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgM level ( J:49405 )

• IgM serum levels are reduced by 50%

hematopoietic system

decreased IgM level ( J:49405 )

• IgM serum levels are reduced by 50%

Allelic Composition	Ighm^tm1Cgn/Ighm⁺
Genetic Background	NOD.129S2-Ighm^tm1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:37287 )

• 90% of female and 45% of male heterozygotes develop diabetes (glycosuric values >3) by 20 weeks of age compared to 0% of homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:37287

Allelic Composition	Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf/Ighm⁺ Tg(Fcer2a-cre)5Mbu/0
Genetic Background	B6.Cg-Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmin^tm1.1Jhh mutation (2 available); any Atmin mutation (39 available)
Ighm^tm1(Bcl6)Rdf mutation (1 available); any Ighm mutation (58 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor susceptibility ( J:230105 )

• mice exhibit similar tumorigenesis as Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Tg(Fcer2a-cre)5Mbu mice

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Ighm^{tm1.1(IGH-2)Cog}/Ighm⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (58 available)
Ighm^{tm1.1(IGH-2)Cog} mutation (0 available); any Ighm mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:157575 )

• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells

hematopoietic system

abnormal B cell physiology ( J:157575 )

• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells

Allelic Composition	Ighm^tm1Cgn/Ighm⁺ Tgfb1^tm1Doe/Tgfb1^tm1Doe
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CF-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (58 available)
Tgfb1^tm1Doe mutation (4 available); any Tgfb1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell proliferation ( J:99033 )

• splenocytes of Day 12-19 mutants are hyperresponsive to LPS stimulation in culture compared to Igh-6 heterozygous splenocytes

immune system

thymus hypoplasia ( J:99033 )

• animals display decreased thymic cellularity

hematopoietic system

thymus hypoplasia ( J:99033 )

• animals display decreased thymic cellularity

endocrine/exocrine glands

thymus hypoplasia ( J:99033 )

• animals display decreased thymic cellularity

Allelic Composition	Ighm^tm1Cgn/Ighm⁺ Tg(Igh-6/Igh-V125)2Jwt/0 Tg(Igk-C/Igk-V125)1Jwt/0
Genetic Background	NOD.Cg-Ighm^tm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (58 available)
Tg(Igh-6/Igh-V125)2Jwt mutation (1 available)
Tg(Igk-C/Igk-V125)1Jwt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice

immune system

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice

increased susceptibility to autoimmune diabetes ( J:91865 )

• transgenic females heterozygous for Igh-6 develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at a slightly earlier time (12 weeks) than homozygous transgenic females but the incidence is the same by 17 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91865 )

Allelic Composition	Ighm^tm1Cgn/Ighm⁺ Tg(Igh-6/Igh-V281)3Jwt/0
Genetic Background	NOD.Cg-Ighm^tm1Cgn Tg(Igh-6/Igh-V281)3Jwt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (18 available); any Ighm mutation (58 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:91865

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