All Phenotypes Igf2r<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf2r⁺
wild type
MGI:2431039

Summary

41 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2r^tm2Arge/Igf2r⁺	involves: 129	MGI:3820221
ht2	Igf2r^tm1Arge/Igf2r⁺	involves: 129	MGI:3820222
ht3	Igf2r^tm1Stw/Igf2r⁺	involves: 129S1/Sv * C57BL/6	MGI:3820400
ht4	Igf2r^tm1Wag/Igf2r⁺	involves: 129S2/SvPas	MGI:3521792
ht5	Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820281
ht6	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820283
ht7	Igf2r^tm2Wag/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3820080
ht8	Igf2r^tm1.1Rlj/Igf2r⁺	involves: 129/Sv * BALB/cJ * C57BL/6J	MGI:3795370
ht9	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * C57BL/6J * MF1	MGI:3820209
ht10	Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * C57BL/6J * MF1	MGI:3820208
ht11	Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * MF1	MGI:3820213
ht12	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * MF1	MGI:3820214
ht13	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺	involves: C57BL/6J * C57BL/6NTac	MGI:5505549
cn14	Igf2r^tm1Rlj/Igf2r⁺ Tg(Ckmm-cre)1Lrsn/0	involves: 129 * C57BL/6J	MGI:3795377
cn15	Igf2r^tm1Rlj/Igf2r⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129/Sv * C57BL/6 * DBA	MGI:3795373
cx16	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3845907
cx17	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820274
cx18	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820255
cx19	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820261
cx20	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx21	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820290
cx22	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820301
cx23	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820302
cx24	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820303
cx25	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820304
cx26	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820305
cx27	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820306
cx28	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820307
cx29	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820308
cx30	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820275
cx31	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820278
cx32	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820279
cx33	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820288
cx34	Igf2r^tm2Wag/Igf2r⁺ Del(17)T^hp/+	involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6	MGI:3820082
cx35	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820232
cx36	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820238
cx37	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820239
cx38	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820233
cx39	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820217
cx40	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820218
cx41	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺	involves: C57BL/6J * C57BL/6NTac	MGI:5505550

Allelic Composition	Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• Background Sensitivity: survival rate is dependent on strain background

perinatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• however, when this allele is inherited paternally no abnormal lethality is observed

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die postnatally

reproductive system

abnormal uterus morphology ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

enlarged uterus ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice

vagina atresia ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

reduced female fertility ( J:34584 )

• when this allele is inherited maternally, 2 of 3 females are infertile

reduced male fertility ( J:34584 )

• when this allele is inherited maternally, 1 of 6 males is infertile

cardiovascular system

thick interventricular septum ( J:34584 )

• when this allele is inherited maternally, the ventricular septum width is increased compared to in wild-type mice

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased heart left ventricle wall thickness ( J:34584 )

• when this allele is inherited maternally, mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia

• when this allele is inherited maternally, mice exhibit a 4-fold larger wall volume compared to in wild-type mice

dilated heart left ventricle ( J:34584 )

• an 89% increase compared to in wild-type mice when this allele is inherited maternally

dilated heart right ventricle ( J:34584 )

• when this allele is inherited maternally

congestive heart failure ( J:34584 )

• when this allele is inherited maternally, perinatal lethality is likely caused by decompensated heart failure

homeostasis/metabolism

abnormal circulating hormone level ( J:34584 )

• when this allele is inherited maternally, IGF-II serum levels are 4.4-fold higher than in wild-type mice

edema ( J:34584 )

• when this allele is inherited maternally, mice are edematous at E17.5 and E18.5 unlike wild-type mice

growth/size/body

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

increased birth body size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at birth

abnormal body water content ( J:34584 )

• when this allele is inherited maternally, water content at E17.5 and E18.5 is increased compared to in wild-type mice

increased fetal size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at E18.5

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

limbs/digits/tail

polydactyly ( J:34584 )

• postaxial when this allele is inherited maternally

kinked tail ( J:34584 )

• when this allele is inherited maternally

embryo

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

enlarged placenta ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

liver/biliary system

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

nervous system

increased brain size ( J:34584 )

• when this allele is inherited maternally

renal/urinary system

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

hematopoietic system

increased nucleated erythrocyte cell number ( J:34584 )

• when this allele is inherited maternally, immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice

respiratory system

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• Background Sensitivity: survival rate is dependent on strain background

perinatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• however, when this allele is inherited paternally no abnormal lethality is observed

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die postnatally

reproductive system

abnormal uterus morphology ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

enlarged uterus ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice

vagina atresia ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

reduced female fertility ( J:34584 )

• when this allele is inherited maternally, 2 of 3 females are infertile

reduced male fertility ( J:34584 )

• when this allele is inherited maternally, 1 of 6 males is infertile

cardiovascular system

thick interventricular septum ( J:34584 )

• when this allele is inherited maternally, the ventricular septum width is increased compared to in wild-type mice

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased heart left ventricle wall thickness ( J:34584 )

• when this allele is inherited maternally, mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia

• when this allele is inherited maternally, mice exhibit a 4-fold larger wall volume compared to in wild-type mice

dilated heart left ventricle ( J:34584 )

• an 89% increase compared to in wild-type mice when this allele is inherited maternally

dilated heart right ventricle ( J:34584 )

• when this allele is inherited maternally

congestive heart failure ( J:34584 )

• when this allele is inherited maternally, perinatal lethality is likely caused by decompensated heart failure

homeostasis/metabolism

abnormal circulating hormone level ( J:34584 )

• when this allele is inherited maternally, IGF-II serum levels are 4.4-fold higher than in wild-type mice

edema ( J:34584 )

• when this allele is inherited maternally, mice are edematous at E17.5 and E18.5 unlike wild-type mice

growth/size/body

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

increased birth body size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at birth

abnormal body water content ( J:34584 )

• when this allele is inherited maternally, water content at E17.5 and E18.5 is increased compared to in wild-type mice

increased fetal size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at E18.5

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

limbs/digits/tail

polydactyly ( J:34584 )

• postaxial when this allele is inherited maternally

kinked tail ( J:34584 )

• when this allele is inherited maternally

embryo

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

enlarged placenta ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

liver/biliary system

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

nervous system

increased brain size ( J:34584 )

• when this allele is inherited maternally

renal/urinary system

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

hematopoietic system

increased nucleated erythrocyte cell number ( J:34584 )

• when this allele is inherited maternally, immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice

respiratory system

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

Allelic Composition	Igf2r^tm1Stw/Igf2r⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Stw mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:22124 )

• when this allele is inherited maternally, only 3.4% of mice from one breeding pair survived to adulthood

neonatal lethality, incomplete penetrance ( J:22124 )

• when this allele is inherited maternally, nearly all mice die within 12 hours of birth due to respiratory failure

• however, when this allele is inherited paternally mice exhibit normal survival and phenotype

reproductive system

absent endometrial glands ( J:22124 )

• in surviving mice when this allele is inherited maternally

abnormal external female genitalia morphology ( J:22124 )

• when this allele is inherited maternally, surviving mice exhibit vulval closure

thin endometrium ( J:22124 )

• when this allele is inherited maternally, surviving mice exhibit reduced endometrium thickness compared to in wild-type mice

enlarged uterus ( J:22124 )

• when this allele is inherited maternally, the uterus of mice that survive to adulthood is 7 times larger than in wild-type mice due to fluid accumulation secondary to an imperforate vagina

vagina atresia ( J:22124 )

• when this allele is inherited maternally, surviving mice exhibit imperforate vagina

female infertility ( J:22124 )

• two viable females recovered with a maternally inherited allele were infertile

reduced male fertility ( J:22124 )

• of the two viable males recovered one was infertile while the other was fertile

cardiovascular system

abnormal myocardium layer morphology ( J:22124 )

• when this allele is inherited maternally, mice exhibit myocardium hyperplasia

abnormal tricuspid valve development ( J:22124 )

• when this allele is inherited maternally, the tricuspid valve develops poorly

abnormal interventricular septum morphology ( J:22124 )

• when this allele is inherited maternally, the intraventricular septum develops large, blood-filled sinusoids and reduced cell thickness to no more than 2 cells in diameter unlike in wild-type mice

enlarged heart ( J:22124 )

• when this allele is inherited maternally, heart size is 3 times larger than in wild-type mice at E19 and is enalrged in surviving mice

increased heart weight ( J:22124 )

• when this allele is inherited maternally

increased heart right ventricle size ( J:22124 )

• when this allele is inherited maternally

respiratory system

respiratory distress ( J:22124 )

• when this allele is inherited maternally, some mice have difficulty breathing

respiratory failure ( J:22124 )

• when this allele is inherited maternally, most mice fail to breath at birth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:22124 )

N	• despite an increase in serum Igf2 levels, glucose serum levels are normal

abnormal circulating hormone level ( J:22124 )

• when this allele is inherited maternally, Igf2 serum levels are increased compared to in wild-type mice

cyanosis ( J:22124 )

• at birth when this allele is inherited maternally

embryo

increased placenta weight ( J:22124 )

• when this allele is inherited maternally, the weight of placenta and fetal membranes is increased 25% to 30% compared to in wild-type mice at E17 and continues to increase throughout the rest of the pregnancy unlike in wild-type mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:22124 )

• when this allele is inherited maternally, mice are unable to move effectively unlike wild-type mice

absent suckling reflex ( J:22124 )

• when this allele is inherited maternally

growth/size/body

enlarged heart ( J:22124 )

• when this allele is inherited maternally, heart size is 3 times larger than in wild-type mice at E19 and is enalrged in surviving mice

increased heart weight ( J:22124 )

• when this allele is inherited maternally

increased birth body size ( J:22124 )

• when this allele is inherited maternally, mice are larger at birth with proportional increases in liver and lung weights

limbs/digits/tail

kinked tail ( J:22124 )

• when this allele is inherited maternally

endocrine/exocrine glands

absent endometrial glands ( J:22124 )

• in surviving mice when this allele is inherited maternally

muscle

abnormal myocardium layer morphology ( J:22124 )

• when this allele is inherited maternally, mice exhibit myocardium hyperplasia

Allelic Composition	Igf2r^tm1Wag/Igf2r⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Wag mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:20763 )

• heterozygous pups inheriting the maternal allele are moribund at birth or die within 2 weeks of birth

• Background Sensitivity: a small number of heterozygotes that inherited the maternal allele survive long-term on a 129/Sv * C57BL6 background but on a 129/Sv background no mutants survive

perinatal lethality, incomplete penetrance ( J:20763 )

• heterozygous pups inheriting the maternal allele are moribund at birth or die within 2 weeks of birth

growth/size/body

enlarged heart ( J:20763 )

• heterozygotes inheriting the maternal allele have hearts 2 to 5 times the size of controls

abnormal embryonic growth/weight/body size ( J:20763 )

• heterozygotes carrying the materrnal allele are 30% heavier in dry weight than littermates

cardiovascular system

disorganized myocardium ( J:20763 )

• ventricular myocardium is disorganized in heterozygotes inheriting the maternal allele

enlarged heart ( J:20763 )

• heterozygotes inheriting the maternal allele have hearts 2 to 5 times the size of controls

respiratory system

abnormal lung morphology ( J:20763 )

• E18.5 moribund mutants inheriting the maternal allele have lungs that appear retarded and have poorly formed alveoli

respiratory failure ( J:20763 )

• heterozygotes inheriting the maternal allele cannot initiate or sustain respiration and die at birth

limbs/digits/tail

polydactyly ( J:20763 )

• heterozygotes inheriting the maternal allele have a single extra toe on the postaxial side of the fore and hindfeet

kinked tail ( J:20763 )

• heterozygous animals inheriting the maternal allele have a tail bend; the tail straightens with age on those heterozygotes that survive past birth

skeleton

split sternum ( J:20763 )

• some of the moribund mutants inheriting the maternal allele show split sternum

abnormal bone ossification ( J:20763 )

• moribund mutants inheriting the maternal allele have ossified extra toes and fused third and fourth sternum ossification centers

premature bone ossification ( J:20763 )

• E18.5 mutants that inherit the maternal allele exhibit ossification of the limb phalanges and tail vertebrae characteristic of later post-natal stages

reproductive system

enlarged uterus ( J:20763 )

• two surviving females that inherited the maternal allele had enlarged uteri connecting to a fused vagina rendering them infertile

vagina atresia ( J:20763 )

• two surviving females that inherited the maternal allele had enlarged uteri connecting to a fused vagina rendering them infertile

craniofacial

abnormal craniofacial morphology ( J:20763 )

• following maternal transmission, animal display a facial dysmorphism

cellular

abnormal lysosome physiology ( J:20763 )

• in mutants inheriting the maternal allele, four of five lysosomal enzymes looked at were reduced 30-80% in embryonic fibroblasts compared to wild-type levels, although this was not apparent in E14.5 mutant embryos or hearts and livers from E18.5 embryos

maternal imprinting ( J:20763 )

• animals inheriting the paternal allele are viable and fertile, while those inheriting the maternal inactivated allele die at birth or postnatally with a wide variety of abnormalities

muscle

disorganized myocardium ( J:20763 )

• ventricular myocardium is disorganized in heterozygotes inheriting the maternal allele

Allelic Composition	Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2r^tm2Wag/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal weight ( J:68721 )

• when the allele is inherited paternally, mice exhibit a 20% decrease in weight compared to wild-type mice beginning at E17.5 and continuing throughout adulthood

• however, when this allele is inherited maternally mice have normal weights

Allelic Composition	Igf2r^tm1.1Rlj/Igf2r⁺
Genetic Background	involves: 129/Sv * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1.1Rlj mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:80932 )

• no mutant mice are recovered at birth

embryo

increased embryo size ( J:80932 )

• mutants are 36% larger than wild-type at E18.5

enlarged placenta ( J:80932 )

• placentas of mutant embryos are 30% larger than corresponding wild-type organs of E18.5 embryos

growth/size/body

increased embryo size ( J:80932 )

• mutants are 36% larger than wild-type at E18.5

respiratory system

abnormal lung development ( J:80932 )

• at E18.5, lungs are poorly developed

impaired branching involved in preterminal bronchiole morphogenesis ( J:80932 )

• low frequency of bronchiole structures is observed

limbs/digits/tail

short tail ( J:80932 )

• tails of embryos are shorter and blunter than wild-type

kinked tail ( J:80932 )

• some mutant tails possess a characteristic kink in the tip

cellular

genetic imprinting ( J:80932 )

• the paternally-inherited Igf2r allele is normallly silenced through genomic imprinting so embryos inheriting the Igf2r-null allele maternally are functionally homozygous knockouts

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * C57BL/6J * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

lethality throughout fetal growth and development, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die between E17.5 and E18.5

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

Allelic Composition	Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * C57BL/6J * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

lethality throughout fetal growth and development, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die between E17.5 and E18.5

postnatal lethality, incomplete penetrance ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

Allelic Composition	Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

postnatal lethality, incomplete penetrance ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

postnatal lethality, incomplete penetrance ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

Allelic Composition	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased body size in Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺ mice when the allele is inherited maternally

mortality/aging

preweaning lethality, incomplete penetrance ( J:197171 )

• when the allele is inherited maternally, fewer than expected pups survive to P10

• however, all pups are viable when this allele is inherited paternally

reproductive system

abnormal uterine horn morphology ( J:197171 )

• dilated, enlarged and fluid filled when the allele is inherited maternally

dilated uterine horn ( J:197171 )

• when the allele is inherited maternally

enlarged uterine horn ( J:197171 )

• when the allele is inherited maternally

decreased litter size ( J:197171 )

• when the allele is inherited maternally

• however, all pups are viable when this allele is inherited paternally

cardiovascular system

increased heart weight ( J:197171 )

• at E14.5 and at E18.5 without hypertrophy when the allele is inherited maternally

• however, heart weight was not disproportional at E18.5

increased heart ventricle size ( J:197171 )

• increased ventricular muscle with blood filled spaces at E18.5 when the allele is inherited maternally

dilated heart ( J:197171 )

• when the allele is inherited maternally

heart hemorrhage ( J:197171 )

• increased ventricular muscle with blood filled spaces at E18.5 when the allele is inherited maternally

growth/size/body

increased heart weight ( J:197171 )

• at E14.5 and at E18.5 without hypertrophy when the allele is inherited maternally

• however, heart weight was not disproportional at E18.5

increased body size ( J:197171 )

• when the allele is inherited maternally

increased body weight ( J:197171 )

• when the allele is inherited maternally

• however, adult weight is normal when the allele is inherited paternally

increased fetal weight ( J:197171 )

• at E14.5, E17.5 and E18.5 when the allele is inherited maternally

embryo

increased placenta weight ( J:197171 )

• at E14.5 and E18.5 when the allele is inherited maternally

Allelic Composition	Igf2r^tm1Rlj/Igf2r⁺ Tg(Ckmm-cre)1Lrsn/0
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Rlj mutation (0 available); any Igf2r mutation (101 available)
Tg(Ckmm-cre)1Lrsn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80932 )

cellular

genetic imprinting ( J:80932 )

• the paternally-inherited Igf2r allele is normally silenced through genomic imprinting so embryos inheriting the floxed Igf2r allele maternally are functionally muscle-specific homozygous knockouts

Allelic Composition	Igf2r^tm1Rlj/Igf2r⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129/Sv * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Rlj mutation (0 available); any Igf2r mutation (101 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:80932 )

N	• no histologic differences are detected

normal phenotype

no abnormal phenotype detected ( J:80932 )

• mice show no significant differences from wild-type in body or organ weights

cellular

genetic imprinting ( J:80932 )

• the paternally-inherited Igf2r allele is normally silenced through genomic imprinting so embryos inheriting the floxed Igf2r allele maternally are functionally liver-specific homozygous knockouts

Allelic Composition	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Stw mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)
Rr28^tm1Tilg mutation (0 available); any Rr28 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice die immediately after birth

limbs/digits/tail

polydactyly ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice exhibit postaxial polydactyly that is confined to a single forelimb

growth/size/body

increased fetal weight ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice weigh 135% of wild-type

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2r^tm2Arge is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)
M6pr^tm1Hlk mutation (0 available); any M6pr mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2r^tm1Arge is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf2r^tm2Wag/Igf2r⁺ Del(17)T^hp/+
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)T^hp mutation (3 available); any Del(17)T^hp mutation (2 available)
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:68721 )

• when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, some mice survive birth and reach maturity despite some prenatal lethality

prenatal lethality, incomplete penetrance ( J:68721 )

• when the allele is inherited paternally, fewer than expected mice are born

• however, unlike when only T^hp is inherited maternally, some mice are recovered at birth

limbs/digits/tail

abnormal tail morphology ( J:68721 )

• when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, mice have a bent tail compared to wild-type mice

reproductive system

reproductive system phenotype ( J:68721 )

N	• when the allele is inherited paternally, mice are fertile

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when this allele is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (101 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

growth/size/body

growth/size/body region phenotype ( J:197171 )

N	• rescue of postnatal overgrowth observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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