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Igf2rtm2Wag
Targeted Allele Detail
Summary
Symbol: Igf2rtm2Wag
Name: insulin-like growth factor 2 receptor; targeted mutation 2, Erwin F Wagner
MGI ID: MGI:2445841
Synonyms: R2D, R2Delta, Rr695536tm2Wag
Gene: Igf2r  Location: Chr17:12901293-12988551 bp, - strand  Genetic Position: Chr17, 8.64 cM, cytoband A-C
Alliance: Igf2rtm2Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68721
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous allele was released from imprint-mediated regulation by deleting the CpG rich sequences of region 2 in intron 2 ( Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igf2r Mutation:  99 strains or lines available
References
Original:  J:68721 Wutz A, et al., Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development. 2001 May;128(10):1881-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory