All Phenotypes Igf2r<tm2Wag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf2r^tm2Wag
targeted mutation 2, Erwin F Wagner
MGI:2445841

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2r^tm2Wag/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3820080
ht2	Igf2r^tm1Wag/Igf2r^tm2Wag	involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3820081
ht3	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^tm2Wag	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac	MGI:5505551
cx4	Igf2r^tm2Wag/Igf2r⁺ Del(17)T^hp/+	involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6	MGI:3820082

Allelic Composition	Igf2r^tm2Wag/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal weight ( J:68721 )

• when the allele is inherited paternally, mice exhibit a 20% decrease in weight compared to wild-type mice beginning at E17.5 and continuing throughout adulthood

• however, when this allele is inherited maternally mice have normal weights

Allelic Composition	Igf2r^tm1Wag/Igf2r^tm2Wag
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Wag mutation (0 available); any Igf2r mutation (98 available)
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:68721 )

N	• when the allele is inherited paternally, mice are viable

reproductive system

reproductive system phenotype ( J:68721 )

N	• when the allele is inherited paternally, mice are fertile

growth/size/body

growth/size/body region phenotype ( J:68721 )

N	• when the allele is inherited paternally, body weights are normal

Allelic Composition	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^tm2Wag
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (98 available)
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

Allelic Composition	Igf2r^tm2Wag/Igf2r⁺ Del(17)T^hp/+
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)T^hp mutation (3 available); any Del(17)T^hp mutation (2 available)
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:68721 )

• when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, some mice survive birth and reach maturity despite some prenatal lethality

prenatal lethality, incomplete penetrance ( J:68721 )

• when the allele is inherited paternally, fewer than expected mice are born

• however, unlike when only T^hp is inherited maternally, some mice are recovered at birth

limbs/digits/tail

abnormal tail morphology ( J:68721 )

• when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, mice have a bent tail compared to wild-type mice

reproductive system

reproductive system phenotype ( J:68721 )

N	• when the allele is inherited paternally, mice are fertile

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