Igf2r^tm1Wag
Targeted Allele Detail

Summary

• Symbol: Igf2r^tm1Wag
• Name: insulin-like growth factor 2 receptor; targeted mutation 1, Erwin F Wagner
• MGI ID: MGI:2181637
• Synonyms: Mpr300^-
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^tm1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20763
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of 96 bp of the first exon by a nls-lacZ-p[A] cassette, inserted in-frame following the first four codons, and a RSV-neo-p[A] cassette via homologous recombination. Absence of gene expression in homozygous mutant embryos was verified by Northern blot analysis. (J:20763)

Expression

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 98 strains or lines available

References

• Original: J:20763 Wang ZQ, et al., Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature. 1994 Dec 1;372(6505):464-7
• All: 9 reference(s)