Igf2r^{tm1.1(IGF2R)Arte}
Targeted Allele Detail

Summary

• Symbol: Igf2r^{tm1.1(IGF2R)Arte}
• Name: insulin-like growth factor 2 receptor; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5505532
• Synonyms: Igf2r^HU
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^{tm1.1(IGF2R)Arte} page

Increased body size in Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺ mice when the allele is inherited maternally

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Humanized sequence, Inserted expressed sequence) Mutation: Insertion Mutation details: A targeting vector inserted an FRT-flanked human cDNA (exons 3 through 48) into intron 2. Cre-mediated recombination removed the floxed puromycin resistance cassette inserted downstream of the human cDNA. This allele is humanized. Western blot analysis confirmed reduced protein expression in the lower limb and heart when the allele is inherited maternally. Paternal inheritance of the allele does not exhibit altered protein expression. (J:197171)

Generation of the Igf2r^tm1.1(IGF2R)Arte allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 98 strains or lines available

References

• Original: J:197171 Hughes J, et al., Maternal transmission of a humanised igf2r allele results in an igf2 dependent hypomorphic and non-viable growth phenotype. PLoS One. 2013;8(2):e57270
• All: 1 reference(s)