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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grik4+
wild type
MGI:2430772
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Grik4tm1(cre)Ksak/Grik4+ C57BL/6-Grik4tm1(cre)Ksak MGI:4360482
cn2
 		Grin2btm1Ksak/Grin2btm1Ksak
Grik4tm1(cre)Ksak/Grik4+ 		C57BL/6-Grin2btm1Ksak Grik4tm1(cre)Ksak MGI:4360481
cn3
 		Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+ 		involves: C57BL/6 MGI:4398696
cn4
 		Grik4tm1(cre)Mim/Grik4+
Grin1tm1Mim/Grin1tm1Mim 		involves: C57BL/6N MGI:4356068


Genotype
MGI:4360482
ht1
Allelic
Composition		 Grik4tm1(cre)Ksak/Grik4+
Genetic
Background		 C57BL/6-Grik4tm1(cre)Ksak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik4tm1(cre)Ksak mutation (0 available); any Grik4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:152455 )
• mice are viable, fertile and do not display any overt behavioral or anotomic phenotype




Genotype
MGI:4360481
cn2
Allelic
Composition		 Grin2btm1Ksak/Grin2btm1Ksak
Grik4tm1(cre)Ksak/Grik4+
Genetic
Background		 C57BL/6-Grin2btm1Ksak Grik4tm1(cre)Ksak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik4tm1(cre)Ksak mutation (0 available); any Grik4 mutation (48 available)
Grin2btm1Ksak mutation (0 available); any Grin2b mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:152455 )
N
• normal brain structure and morphology
• no overt behavioral phenotype
abnormal dendrite morphology ( J:152455 )
• reduced dendritic spine density
abnormal synapse morphology ( J:152455 )
• increased detergent solubility of GluN2A subunit and PSD-95 in mutant CA3
• decreased F-actin content
• reduced GluN1 subunit from the postsynaptic site
absence of NMDA-mediated synaptic currents ( J:152455 )
• NMDAR-mediated synaptic currents are abolished in three excitatory CA3 synapses: the commissural/associative-CA3 synapse, commissural-CA3 synapse, and mossy fiber-CA3 synapse
• reduced but detectable extrasynaptic NMDAR-mediated currents
reduced long-term potentiation ( J:152455 )
• LTP is abolished at the commissural/associative-CA3 synapse and commissural-CA3 synapse
• mossy fiber-CA3 synapse are normal




Genotype
MGI:4398696
cn3
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2.1Kldr mutation (0 available); any Epha4 mutation (68 available)
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (68 available)
Grik4tm1.1(cre)Slab mutation (2 available); any Grik4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:154648 )
N
• mice exhibit normal long term potentiation and excitatory postsynaptic potential to theta burst- and tetanus-induced stimulation




Genotype
MGI:4356068
cn4
Allelic
Composition		 Grik4tm1(cre)Mim/Grik4+
Grin1tm1Mim/Grin1tm1Mim
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik4tm1(cre)Mim mutation (0 available); any Grik4 mutation (48 available)
Grin1tm1Mim mutation (0 available); any Grin1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased susceptibility to kainate-induced tonic-clonic seizures in Grin1tm1Mim/Grin1tm1Mim Grik4tm1(cre)Mim/Grik4+ mice

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:144994 )
• mutants are more susceptible to kainate induced tonic-clonic seizures than controls
abnormal postural reflex ( J:144994 )
• intraperitoneal injection of 8 mg/kg kainate results in loss of postural reflex along with seizures in mutants within 1 hour but not in controls
tonic-clonic seizures ( J:144994 )
• intraperitoneal injection of 8 mg/kg kainate induces seizures in 8 week-old mutants within 1 hour but not in wild-type controls; higher doses cause seizures in all genotypes, but latency in mutants is significantly shorter

nervous system
nervous system phenotype ( J:144994 )
N
• dendritic arborization of CA3 pyramidal neurons is comparable to controls
increased susceptibility to pharmacologically induced seizures ( J:144994 )
• mutants are more susceptible to kainate induced tonic-clonic seizures than controls
tonic-clonic seizures ( J:144994 )
• intraperitoneal injection of 8 mg/kg kainate induces seizures in 8 week-old mutants within 1 hour but not in wild-type controls; higher doses cause seizures in all genotypes, but latency in mutants is significantly shorter
abnormal nervous system electrophysiology ( J:144994 )
• high frequency stimulation induces slowly decaying outward currents in CA3 pyramidal cells of control mice but not in mutants
abnormal brain wave pattern ( J:144994 )
• field potential recordings in the CA3 region at 8 weeks reveal characteristic spikes with large amplitudes that are not observed in controls; these spikes originate in the CA3 and CA1 pyramidal cell layers but not in the dentate gyrus
• similar results are obtained when ablation of Grin1 in the CA3 region is accomplished using injection of adenoviral cre




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory