Grik4tm1(cre)Mim
Targeted Allele Detail
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Symbol: |
Grik4tm1(cre)Mim |
Name: |
glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Masayoshi Mishina |
MGI ID: |
MGI:3850720 |
Synonyms: |
GluRgamma1cre |
Gene: |
Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
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Alliance: |
Grik4tm1(cre)Mim page
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Increased susceptibility to kainate-induced tonic-clonic seizures in Grin1tm1Mim/Grin1tm1Mim Grik4tm1(cre)Mim/Grik4+ mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:144994
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Parent Cell Line: |
RENKA (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Grik4tm1(cre)Mim expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Grik4 (MGI:95817) |
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Mutation details: The cre gene was inserted into the translational initiation site of the gene. An frt-flanked neo cassette followed the cre gene. Expression of cre is restricted to hippocampal CA3 pyramidal neurons and does not recapitulate the expression of the endogenous gene, presumably due to the neo cassette insertion.
(J:144994)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Grik4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grik4 Mutation: |
48 strains or lines available
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Original: |
J:144994 Fukushima F, et al., Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons. PLoS One. 2009;4(1):e3993 |
All: |
1 reference(s) |
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