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Grik4tm1.1(cre)Slab
Targeted Allele Detail
Summary
Symbol: Grik4tm1.1(cre)Slab
Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1.1, Ralf Schoepfer
MGI ID: MGI:4398684
Synonyms: CA3-cre
Gene: Grik4  Location: Chr9:42431708-42856296 bp, - strand  Genetic Position: Chr9, 23.8 cM
Alliance: Grik4tm1.1(cre)Slab page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154648
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Grik4tm1.1(cre)Slab expression driven by 1 gene
 
Mutation detailsA cassette containing an IRES sequence, EGFP/cre fusion, and frt flanked neo and histidine markers was inserted into the 3' UTR. Germ line, flp mediated recombination removed the neo and histidine markers. Cre activity is detected in nearly all cells in the CA3 and a smaller fraction of dentate gyrus cells starting at postnatal week 1. (J:154648)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Grik4 (mouse)
Summary of all recombinase alleles driven by Grik4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Grik4 Mutation:  48 strains or lines available
References
Original:  J:154648 Filosa A, et al., Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci. 2009 Oct;12(10):1285-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory