Grin2b^tm1Ksak
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1Ksak
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:4360480
• Synonyms: Grin2b^flox
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank the exon encoding the transmembrane segment M4 and insert a neomycin resistance cassette in the intron before the M4 containing exon. Protein expression was comparable with that in wild-type mice. (J:152455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 100 strains or lines available

References

• Original: J:152455 Akashi K, et al., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009 Sep 2;29(35):10869-82
• All: 9 reference(s)