All Phenotypes Eef1a1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eef1a1⁺
wild type
MGI:2430029

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837707
cn2	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837708
cn3	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837711
cn4	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3837706
cn5	Eef1a1^tm1Tcrl/Eef1a1⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5692456
cn6	Eef1a1^tm2Arge/Eef1a1⁺ Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: C57BL/6 * C57BL/6NTac	MGI:5496427
cn7	Eef1a1^{tm1(FBXW7*)Iaai}/Eef1a1⁺ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5524229
cn8	Eef1a1^tm2Arge/Eef1a1⁺ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5491045

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histology and immunophenotyping of mammary carcinomas in Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺ mice

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

integument

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:146290

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Igf1r^tm2Arge mutation (1 available); any Igf1r mutation (88 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Hsp70-1-cre)1Arge mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:146290 )

Allelic Composition	Eef1a1^tm1Tcrl/Eef1a1⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Eef1a1^tm1Tcrl mutation (0 available); any Eef1a1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

open neural tube ( J:225273 )

• a high percentage of E12.5 embryos exhibit neural tube defects

spina bifida ( J:225273 )

• several E11.5 and E12.5 embryos exhibit spina bifida

mortality/aging

postnatal lethality, complete penetrance ( J:225273 )

• no pups survive beyond P14

lethality throughout fetal growth and development, incomplete penetrance ( J:225273 )

• fewer double heterozygous animals (4.6%) are produced than expected (25%) from a heterozygote x heterozygote mating

• a significant drop in viability occurs between E15.5 and birth

nervous system

open neural tube ( J:225273 )

• a high percentage of E12.5 embryos exhibit neural tube defects

spina bifida ( J:225273 )

• several E11.5 and E12.5 embryos exhibit spina bifida

holoprosencephaly ( J:225273 )

• several E11.5 and E12.5 embryos exhibit holoprosencephaly

Allelic Composition	Eef1a1^tm2Arge/Eef1a1⁺ Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^tm2Arge mutation (0 available); any Eef1a1 mutation (60 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (3 available); any Gt(ROSA)26Sor mutation (1098 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell physiology ( J:196407 )

• leukemia-initiating cells plated in methylcellulose cultures in the presence of tamoxifen exhibit decreased blast colony number and loss of blast colony formation due to increased apoptosis compared with control cells

Allelic Composition	Eef1a1^{tm1(FBXW7*)Iaai}/Eef1a1⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(FBXW7*)Iaai} mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:200006 )

N	• pIpC-treated mice do not develop leukemia

decreased tumor latency ( J:200006 )

• pIpC-treated mice infected with a retrovirus expression a truncated form of Notch1 that is constitutively cleaved in a ligand-independent manner exhibit shorted latency to development of leukemia

Allelic Composition	Eef1a1^tm2Arge/Eef1a1⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^tm2Arge mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased acute lymphoblastic leukemia incidence ( J:197167 )

• T cell acute lymphoblastic leukemia (T-ALL)

• progressive leukemic cells infiltrate the leptomeningeal spaces of the brain

immune system

abnormal double-positive T cell morphology ( J:197167 )

• atypical CD4+CD8+ T cells in the peripheral blood

hematopoietic system

abnormal double-positive T cell morphology ( J:197167 )

• atypical CD4+CD8+ T cells in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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