Eef1a1^tm2Arge
Targeted Allele Detail

Summary

• Symbol: Eef1a1^tm2Arge
• Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 2, Argiris Efstratiadis
• MGI ID: MGI:5491024
• Synonyms: Eef1a1^{tm2(Notch1)Arge}, Ef1a1-lsl-Notch1^IC1, EF1a^lslN1-IC, EF1-Notch1-IC
• Gene: Eef1a1 Location: Chr9:78385735-78389006 bp, - strand Genetic Position: Chr9, 43.65 cM, cytoband E1
• Alliance: Eef1a1^tm2Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The intracellular domain of Notch1 was inserted into the gene. Expression is blocked by a floxed DNA segment. (J:197167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef1a1 Mutation: 60 strains or lines available

References

• Original: J:197167 Buonamici S, et al., CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature. 2009 Jun 18;459(7249):1000-4
• All: 8 reference(s)