All Phenotypes Igh<tm4Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm4Cgn
targeted mutation 4, University of Cologne
MGI:2388394

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm4Cgn/Igh⁺	involves: 129P2/OlaHsd	MGI:3693006
ht2	Igh^tm1Kplm/Igh^tm4Cgn	involves: 129P2/OlaHsd	MGI:3693008
cn3	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd	MGI:4430560
cn4	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430557
cn5	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430558
cn6	Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430563
cn7	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430555
cn8	Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430561
cn9	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	Not Specified	MGI:3576498
cx10	Blnk^tm1Kplm/Blnk^tm1Kplm Igh^tm4Cgn/Igh⁺ Igk^tm1Rsky/Igk⁺	involves: 129P2/OlaHsd	MGI:3844072
cx11	Igh^tm1Kplm/Igh^tm4Cgn Tg(Igk-V4CH27)1-2Shc/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3693009

Allelic Composition	Igh^tm4Cgn/Igh⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells

immune system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells

Allelic Composition	Igh^tm1Kplm/Igh^tm4Cgn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1Kplm mutation (0 available); any Igh mutation (43 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgn mutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

abnormal B-1 B cell morphology ( J:115292 )

• B cells expressing only Igh^tm1Kplm (indicating loss of the Igh^tm4Cgn allele) are phenotypically B-1 cells

immune system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgn mutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

abnormal B-1 B cell morphology ( J:115292 )

• B cells expressing only Igh^tm1Kplm (indicating loss of the Igh^tm4Cgn allele) are phenotypically B-1 cells

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (31 available)
Foxo1^tm1Rdp mutation (2 available); any Foxo1 mutation (31 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (31 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(Rac1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

immune system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

Allelic Composition	Blnk^tm1Kplm/Blnk^tm1Kplm Igh^tm4Cgn/Igh⁺ Igk^tm1Rsky/Igk⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnk^tm1Kplm mutation (0 available); any Blnk mutation (76 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (43 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:120460 )

• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes

• two populations are detected in the bone marrow consisting of IgM^lo and IgM^hi groups

• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24

• based on intensity of these surface markers, the IgM^lo population is the less mature of the two

• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM⁺ cells

• B cells in the periphery are primarily T1 stage B cells that have a short half-life

increased transitional stage B cell number ( J:120460 )

• B cells in the periphery are primarily T1 stage B cells

decreased B cell number ( J:120460 )

• B cell numbers are decreased 2- to 3- fold in the spleen

• the B cells present are primarily T1 stage B cells

increased pre-B cell number ( J:120460 )

• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

hematopoietic system

abnormal B cell differentiation ( J:120460 )

• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes

• two populations are detected in the bone marrow consisting of IgM^lo and IgM^hi groups

• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24

• based on intensity of these surface markers, the IgM^lo population is the less mature of the two

• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM⁺ cells

• B cells in the periphery are primarily T1 stage B cells that have a short half-life

increased transitional stage B cell number ( J:120460 )

• B cells in the periphery are primarily T1 stage B cells

decreased B cell number ( J:120460 )

• B cell numbers are decreased 2- to 3- fold in the spleen

• the B cells present are primarily T1 stage B cells

increased pre-B cell number ( J:120460 )

• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

Allelic Composition	Igh^tm1Kplm/Igh^tm4Cgn Tg(Igk-V4CH27)1-2Shc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:115292 )

• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system

increased B cell number ( J:115292 )

• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Igh^tm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

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