All Phenotypes Pik3cd<tm1Tnr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr	B6.129S4-Pik3cd^tm1Tnr	MGI:3796440
hm2	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr	involves: 129S4/SvJae	MGI:3796437
hm3	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr	involves: 129S4/SvJae * C57BL/6J	MGI:7645242
cn4	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pten^tm2.1Ppp/Pten^tm2.1Ppp Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:3796508
cx5	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr	B6.129-Pik3cd^tm1Tnr Pik3cg^tm1Pngr	MGI:3796518
cx6	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3796506
cx7	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Tg(BCL2)36Wehi/0	involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi	MGI:3796509

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr
Genetic Background	B6.129S4-Pik3cd^tm1Tnr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cd^tm1Tnr mutation (0 available); any Pik3cd mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:134324 )

• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice

decreased inflammatory response ( J:134324 )

• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice

• however, neutrophil migration in response to fMLP is normal

skeleton

decreased susceptibility to induced arthritis ( J:134324 )

• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:79133 )

• splenic B220+ CD^hi B cells are absent unlike in wild-type mice

decreased B-1 B cell number ( J:79133 )

• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice

decreased B-2 B cell number ( J:79133 )

• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age

decreased marginal zone B cell number ( J:79133 )

• CD21^hi CD23^lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice

abnormal B cell physiology ( J:113491 )

• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice

• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice

decreased B cell proliferation ( J:79133 , J:113491 )

• in response to anti-IgM, CD40 and IL-4 (J:79133)

• however, B cell proliferation response to LPS is normal (J:79133)

decreased IgG1 level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice

decreased IgG2a level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice

decreased IgG2b level ( J:79133 )

• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice

decreased IgG3 level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice

decreased IgM level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice

abnormal humoral immune response ( J:79133 )

• following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice

hematopoietic system

decreased B cell number ( J:79133 )

• splenic B220+ CD^hi B cells are absent unlike in wild-type mice

decreased B-1 B cell number ( J:79133 )

• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice

decreased B-2 B cell number ( J:79133 )

• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age

decreased marginal zone B cell number ( J:79133 )

• CD21^hi CD23^lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice

abnormal B cell physiology ( J:113491 )

• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice

• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice

decreased B cell proliferation ( J:79133 , J:113491 )

• in response to anti-IgM, CD40 and IL-4 (J:79133)

• however, B cell proliferation response to LPS is normal (J:79133)

decreased IgG1 level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice

decreased IgG2a level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice

decreased IgG2b level ( J:79133 )

• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice

decreased IgG3 level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice

decreased IgM level ( J:79133 )

• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice

cellular

decreased B cell proliferation ( J:79133 , J:113491 )

• in response to anti-IgM, CD40 and IL-4 (J:79133)

• however, B cell proliferation response to LPS is normal (J:79133)

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cd^tm1Tnr mutation (0 available); any Pik3cd mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet aggregation ( J:114310 )

• platelets exhibit slower shape change and decreased rate and amplitude of aggregation compared to wild-type platelets in response to submaximal concentrations of adenosine diphosphate or phorbol ester, or intermediate and high levels of collagen-related peptide

homeostasis/metabolism

abnormal platelet aggregation ( J:114310 )

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pten^tm2.1Ppp/Pten^tm2.1Ppp Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Pik3cd^tm1Tnr mutation (0 available); any Pik3cd mutation (44 available)
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:130950 )

N	• unlike in Pten deficient mice, B1 B cell numbers are normal in the spleen and peritoneum

abnormal class switch recombination ( J:130950 )

• defects in class switch recombination associated with Pten deficiency are partially reversed

increased marginal zone B cell number ( J:130950 )

• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice

hematopoietic system

abnormal class switch recombination ( J:130950 )

• defects in class switch recombination associated with Pten deficiency are partially reversed

increased marginal zone B cell number ( J:130950 )

• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr
Genetic Background	B6.129-Pik3cd^tm1Tnr Pik3cg^tm1Pngr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cd^tm1Tnr mutation (0 available); any Pik3cd mutation (44 available)
Pik3cg^tm1Pngr mutation (0 available); any Pik3cg mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:134324 )

• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells

• neutrophils travel shorter distances and at slower velocities than wild-type cells

impaired neutrophil recruitment ( J:134324 )

• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice

decreased susceptibility to induced arthritis ( J:134324 )

• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice

• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice

decreased inflammatory response ( J:134324 )

• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:134324 )

• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice

cellular

impaired neutrophil chemotaxis ( J:134324 )

• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells

• neutrophils travel shorter distances and at slower velocities than wild-type cells

hematopoietic system

impaired neutrophil chemotaxis ( J:134324 )

• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells

• neutrophils travel shorter distances and at slower velocities than wild-type cells

impaired neutrophil recruitment ( J:134324 )

• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus lobule morphology ( J:125791 )

• corticomedullary differentiation is lost

small thymus ( J:125791 )

thymus hypoplasia ( J:125791 )

• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice

abnormal T cell differentiation ( J:125791 )

• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression

decreased lymphocyte cell number ( J:125791 )

decreased T cell number ( J:125791 )

• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice

decreased double-positive T cell number ( J:125791 )

• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:125791 )

decreased CD8-positive, alpha-beta T cell number ( J:125791 )

abnormal T cell physiology ( J:125791 )

• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells

hematopoietic system

abnormal thymus lobule morphology ( J:125791 )

• corticomedullary differentiation is lost

small thymus ( J:125791 )

thymus hypoplasia ( J:125791 )

• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice

abnormal T cell differentiation ( J:125791 )

• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression

decreased lymphocyte cell number ( J:125791 )

decreased T cell number ( J:125791 )

• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice

decreased double-positive T cell number ( J:125791 )

• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:125791 )

decreased CD8-positive, alpha-beta T cell number ( J:125791 )

abnormal T cell physiology ( J:125791 )

• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells

endocrine/exocrine glands

abnormal thymus lobule morphology ( J:125791 )

• corticomedullary differentiation is lost

small thymus ( J:125791 )

thymus hypoplasia ( J:125791 )

• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice

Allelic Composition	Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Tg(BCL2)36Wehi/0
Genetic Background	involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cd^tm1Tnr mutation (0 available); any Pik3cd mutation (44 available)
Tg(BCL2)36Wehi mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased follicular B cell number ( J:130950 )

• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

hematopoietic system

decreased follicular B cell number ( J:130950 )

• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

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