Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation
(1 available);
any
Cdkn2a mutation
(62 available)
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neoplasm
N |
• mice display no increased predisposition to developing tumors and do not exhibit any defects in cell cycle regulation
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• DMBA-induced tumors occur later and exhibit a much narrower diversity than those that develop in DMBA treated Cdkn2atm1.1Brn Cdkn2btm1Brn homozygotes
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homeostasis/metabolism
mortality/aging
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• following adenoviral cre treatment, median survival time is 80 days
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neoplasm
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• following adenoviral cre treatment, 100% of mice develop highly invasive thoracic tumors (including malignant mesotheliomas, 47 of 51; rhabdomyosarcomas, 4 of 51; and schwannomas, 1 of 51)
• following adenoviral cre treatment, 75% of mice develop of aggressive malignant mesotheliomas at a shorter latency than in mice carrying other combinations of Cdkn2atm2Brn, Nf2tm2Gth, and Trp53tm1Brn alleles
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• following adenoviral cre treatment, 75% of mice develop of aggressive malignant mesotheliomas at a shorter latency than in mice carrying other combinations of Cdkn2atm2Brn, Nf2tm2Gth, and Trp53tm1Brn alleles
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nervous system
muscle
neoplasm
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• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion
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• following adenoviral cre treatment, 94% of mice develop aggressive thoracic tumors (including malignant mesotheliomas, 15 of 51; and rhabdomyosarcomas, 1 of 51) with the parietal pleura often showing invasion with concomitant pleural effusion
• following adenoviral cre treatment, 1% of mice develop aspecific tumors not induced by adeno-cre treatment
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homeostasis/metabolism
respiratory system
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• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion
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muscle
neoplasm
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• following adenoviral cre treatment, 2 of 13 mice develop malignant mesotheliomas-like thoracic tumors
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Brd mutation
(0 available);
any
Braf mutation
(58 available)
Cdkn2atm1.1Brn mutation
(1 available);
any
Cdkn2a mutation
(62 available)
Tg(Vil1-cre)997Gum mutation
(2 available)
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neoplasm
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• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)
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• 6.4 fold increase in carcinomas relative to mice with unmutated Cdkn2a alleles
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digestive/alimentary system
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• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)
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neoplasm
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• following adenoviral cre treatment, liver tumor development is increased compared to in untreated mice (on average 18% from 3%)
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• following treatment with adenoviral cre, 15% of mice exhibit osseous metaplasia compared to 2% of wild-type mice
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• following treatment with adenoviral cre, meningioma development is increased compared to in untreated mice (on average 37% from 13%)
• meningiomas in adenoviral cre-treated mice share radiological features with human meningiomas
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• following treatment with adenoviral cre, osteoma development is increased compared to in untreated mice (on average 78% from 57%)
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nervous system
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• following treatment with adenoviral cre, meningioma development is increased compared to in untreated mice (on average 37% from 13%)
• meningiomas in adenoviral cre-treated mice share radiological features with human meningiomas
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• following adenoviral cre treatment, hydrocephalus is increased compared to in untreated mice (on average 56% from 36%)
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• following adenoviral cre treatment, meningothelial proliferation is increased compared to in untreated mice (on average 77% from 46%)
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skeleton
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• following treatment with adenoviral cre, osteoma development is increased compared to in untreated mice (on average 78% from 57%)
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liver/biliary system
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• following adenoviral cre treatment, liver tumor development is increased compared to in untreated mice (on average 18% from 3%)
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nervous system
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• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals
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mortality/aging
N |
• mice show similar survival/lifespan to Cdkn2a-sufficient animals
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neoplasm
N |
• no pituitary tumors are observed
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• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals
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mortality/aging
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• no mice are recovered (no time of death given)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation
(1 available);
any
Cdkn2a mutation
(62 available)
Pknox1tm1Fbla mutation
(0 available);
any
Pknox1 mutation
(90 available)
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embryo
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• mice exhibit the same reduced Oct4 expression domain as in Pknox1tm1Fbla homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation
(1 available);
any
Cdkn2a mutation
(62 available)
Cdkn2btm2Brn mutation
(0 available);
any
Cdkn2b mutation
(7 available)
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neoplasm
N |
• untreated mice do not show any increased susceptibility to tumor formation within the first year
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• treatment of newborns with dimethylbenzantrene (DMBA) induces the same tumors as observed in Cdkn2atm1.1Brn/Cdkn2atm1.1Brn Cdkn2btm1Brn/Cdkn2btm1Brn Tg(ACTB-cre)2Mrt mice
• DMBA-induced tumors occur earlier and exhibit a much broader diversity than those that develop in DMBA treated Cdkn2atm1.1Brn homozygotes
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• treatment of newborns with dimethylbenzantrene (DMBA) induces skin tumors
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homeostasis/metabolism
integument
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• treatment of newborns with dimethylbenzantrene (DMBA) induces skin tumors
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