All Phenotypes Lyn<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lyn⁺
wild type
MGI:2182294

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lyn^M1Btlr/Lyn⁺	C57BL/6J-Lyn^M1Btlr	MGI:5603321
ht2	Lyn^M2Btlr/Lyn⁺	C57BL/6J-Lyn^M2Btlr	MGI:5613181
ht3	Lyn^M3Btlr/Lyn⁺	C57BL/6J-Lyn^M3Btlr	MGI:5807133
cx4	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852091
cx5	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852089
cx6	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852087
cx7	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852085

Allelic Composition	Lyn^M1Btlr/Lyn⁺
Genetic Background	C57BL/6J-Lyn^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^M1Btlr mutation (1 available); any Lyn mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

immune system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

Allelic Composition	Lyn^M2Btlr/Lyn⁺
Genetic Background	C57BL/6J-Lyn^M2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^M2Btlr mutation (0 available); any Lyn mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased IgG level ( J:217146 )

• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)

• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)

decreased IgM level ( J:217146 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

immune system

decreased IgG level ( J:217146 )

• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)

• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)

decreased IgM level ( J:217146 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

impaired humoral immune response ( J:217146 )

• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)

• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

Allelic Composition	Lyn^M3Btlr/Lyn⁺
Genetic Background	C57BL/6J-Lyn^M3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^M3Btlr mutation (0 available); any Lyn mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired hematopoiesis ( J:236679 )

• slight

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

immune system

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (62 available)
Lyn^tm1Ard mutation (7 available); any Lyn mutation (66 available)
Tg(IghelMD4)4Ccg mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (7 available); any Lyn mutation (66 available)
Ptpn6^me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 4-fold lower surface IgM levels

Allelic Composition	Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1Ard mutation (7 available); any Lyn mutation (66 available)
Tg(IghelMD4)4Ccg mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• mature B cells have about 2-fold lower surface IgM levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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