Analysis Tools
normal phenotype
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• homozygotes are fertile and show no obvious abnormalities
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Allele Symbol Allele Name Allele ID |
Myctm2Fwa targeted mutation 2, Frederick W Alt MGI:2178233 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are fertile and show no obvious abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired proliferation response to stimulation; cells do not undergo activation
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• impaired proliferation response to stimulation; cells do not undergo activation
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• impaired proliferation response to stimulation; cells do not undergo activation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination
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• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• enforced expression of human MYC rescues germinal center formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased incidence compared to mutant mice wild-type for Myc
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• survival time is increased compared to mutant mice wild-type for Myc
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• decreased incidence compared to mutant mice wild-type for Myc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(CD4-cre)1Cwi mice, the number of double positive thymocytes is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
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• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
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• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
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• at 6 weeks, the manubrium is smaller than normal
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• at 6 weeks, the body of the malleus is smaller than normal
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• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
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• at 6 weeks, the manubrium is smaller than normal
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• at 6 weeks, the body of the malleus is smaller than normal
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• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
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• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
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• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
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• at 6 weeks, the manubrium is smaller than normal
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• at 6 weeks, the body of the malleus is smaller than normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant mice display a clearly demarcated white belly spot
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• mutant mice display a clearly demarcated white belly spot
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant mice exhibit a persistently shorter snout
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• mutant mice are viable but show a ~25% reduction in overall size relative to control littermates
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• mutant mice show a ~25% reduction in weight relative to control littermates
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• all mutants show coat pigmentation defects involving multiple white patches of various sizes that spare the head
• however, no other neural crest-related defects such as cleft palate, spina bifida or exencephaly are observed
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• mutant mice exhibit a noticeably smaller skull
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• frontal bones are defective, with absence of ossification near the metopic region
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• the relative size and position of parietal bones is abnormal
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• mutant mice display predominantly malleal defects
• in contrast, the structure and size of incus and stapes appears normal
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
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• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
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• the manubrium is shorter than normal
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• the body of malleus is smaller than normal
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• mutant mice exhibit a persistently shorter snout
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• mutant mice exhibit a noticeably smaller skull
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• frontal bones are defective, with absence of ossification near the metopic region
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• the relative size and position of parietal bones is abnormal
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• mutant mice display predominantly malleal defects
• in contrast, the structure and size of incus and stapes appears normal
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
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• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
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• the manubrium is shorter than normal
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• the body of malleus is smaller than normal
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• in contrast, the structure and size of incus and stapes appears normal
• mutant mice display predominantly malleal defects
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
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• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
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• the manubrium is shorter than normal
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• the body of malleus is smaller than normal
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• mutant mice display delayed evoked response latencies
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• mutant mice show a significant hearing deficit attributed to malleal defects
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• mutant mice do not appear startled in response to a loud noise e.g. clapping of hands
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• all mutants show coat pigmentation defects involving multiple white patches of various sizes that spare the head
• however, no other neural crest-related defects such as cleft palate, spina bifida or exencephaly are observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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