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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wap+
wild type
MGI:2177236
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1rtm2Arge
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv MGI:3837711
cn2
 		Actbtm1(PyVT)Arge/Actb+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv MGI:3032632
cn3
 		Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv MGI:3837707
cn4
 		Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1r+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv MGI:3837708
cn5
 		Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5494460
cn6
 		Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5494461
cn7
 		Brca1tm2.1Cxd/Brca1tm2Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5494458
cn8
 		Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 MGI:5494459
cn9
 		Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+ 		involves: 129S/SvEv * C57BL/6 MGI:2177237
cx10
 		Tg(tetO-HIST1H2BJ/GFP)47Efu/?
Waptm2(rtTA)Kuw/Wap+ 		involves: 129X1/SvJ * CD-1 MGI:3846834


Genotype
MGI:3837711
cn1
Allelic
Composition		 Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1rtm2Arge
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (60 available)
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (88 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:146290 )
• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

integument
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition




Genotype
MGI:3032632
cn2
Allelic
Composition		 Actbtm1(PyVT)Arge/Actb+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(PyVT)Arge mutation (0 available); any Actb mutation (52 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:87544 )
• premature death

neoplasm

cardiovascular system
decreased cardiac muscle contractility ( J:87544 )
• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

muscle
decreased cardiac muscle contractility ( J:87544 )
• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

integument

endocrine/exocrine glands




Genotype
MGI:3837707
cn3
Allelic
Composition		 Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (60 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Histology and immunophenotyping of mammary carcinomas in Eef1a1tm1(Kras*)Arge/Eef1a1+ Waptm1(cre)Arge/Wap+ mice

mortality/aging
decreased tumor-free survival time ( J:146290 )
• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm
increased mammary gland tumor incidence ( J:146290 )
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:146290 )
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

integument
increased mammary gland tumor incidence ( J:146290 )
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:146290




Genotype
MGI:3837708
cn4
Allelic
Composition		 Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1r+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (60 available)
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (88 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:146290 )
• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition

integument
increased mammary gland tumor incidence ( J:146290 )
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition




Genotype
MGI:5494460
cn5
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (115 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (249 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 308 days compared with 380 days in Trp53tm3Tyj Waptm1(cre)Arge double heterozygotes




Genotype
MGI:5494461
cn6
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (115 available)
Brca1tm3.1Rjbr mutation (1 available); any Brca1 mutation (115 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (249 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor latency ( J:177853 )
• compared with Brca1tm2.1Cxd/Brca1tm2.1Cxd Trp53tm3Tyj/Trp53tm3Tyj Waptm1(cre)Arge/Waptm1(cre)Arge




Genotype
MGI:5494458
cn7
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm2Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (115 available)
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (115 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (249 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 308 days compared with 380 days in Trp53tm3Tyj Waptm1(cre)Arge double heterozygotes
• however, latency is similar to in Brca1tm2.1Cxd/Brca1tm2.1Cxd Trp53tm3Tyj/Trp53+ Waptm1(cre)Arge/Wap+




Genotype
MGI:5494459
cn8
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (115 available)
Brca1tm3.1Rjbr mutation (1 available); any Brca1 mutation (115 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:177853 )
N
• unlike in mice with Brca1tm2.1Cxd/Brca1tm2.1Cxd Waptm1(cre)Arge/Wap+, mice remain tumor free over a 24-month observation period




Genotype
MGI:2177237
cn9
Allelic
Composition		 Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Arge mutation (0 available); any Brca2 mutation (133 available)
Brca2tm2Arge mutation (0 available); any Brca2 mutation (133 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:70564 )
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:70564 )
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

integument
increased mammary adenocarcinoma incidence ( J:70564 )
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:70564




Genotype
MGI:3846834
cx10
Allelic
Composition		 Tg(tetO-HIST1H2BJ/GFP)47Efu/?
Waptm2(rtTA)Kuw/Wap+
Genetic
Background		 involves: 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (3 available)
Waptm2(rtTA)Kuw mutation (1 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:148684 )
• knock-in allele expression determined by use of this strain




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory