Phenotypes associated with this allele

• Allele Symbol: Mesp1^tm2(cre)Ysa
• Allele Name: targeted mutation 2, Yumiko Saga
• Allele ID: MGI:2176467
• Summary: 33 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Mesp1^tm2(cre)Ysa/Mesp1^+	B6.Cg-Mesp1^tm2(cre)Ysa Kmt2d^tm1.1Kaig	MGI:5780094
cn2	Chd7^Gt(XK403)Byg/Chd7^+ Mesp1^tm2(cre)Ysa/Mesp1^+	either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)	MGI:4410361
cn3	Cited2^tm1Bha/Cited2^tm2Bha Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129 * C57BL/6 * CBA * SJL	MGI:3804087
cn4	Mesp1^tm2(cre)Ysa/Mesp1^+ Rbpj^tm1Hon/Rbpj^tm1Hon Tg(CAG-cat,-Notch1)1Ysa/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA	MGI:3808717
cn5	Rbpj^tm1Hon/Rbpj^tm1Hon Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3808716
cn6	Hic2^Gt(E225A08)1.1Wrst/Hic2^Gt(E225A08)1.1Wrst Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5707468
cn7	Dph1^tm1.1Cmch/Dph1^tm1.1Cmch Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5659972
cn8	Sp8^tm1Smb/Sp8^tm2Smb Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:7437667
cn9	Nodal^tm1Mku/Nodal^tm1Mku Mesp1^tm2(cre)Ysa/Mesp1^+ Tg(Pitx2-lacZ)1Mbf/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:4880743
cn10	Mesp1^tm2(cre)Ysa/Mesp1^+ Zic3^tm2.1Jwb/Y	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj	MGI:5470171
cn11	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5558939
cn12	Hey1^tm1Kkb/Hey1^tm1Kkb Mesp1^tm2(cre)Ysa/Mesp1^+ Tg(CAG-cat,-Notch1)1Ysa/0	involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA	MGI:3702490
cn13	Mesp1^tm2(cre)Ysa/Mesp1^+ Tbx1^tm1Bld/Tbx1^tm5Bld	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3686782
cn14	Mesp1^tm2(cre)Ysa/Mesp1^+ Tbx1^tm1Bld/Tbx1^tm3Bld	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3686776
cn15	Dph1^tm2Bhr/Dph1^tm2Bhr Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5659981
cn16	Dph1^tm2Bhr/Dph1^+ Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5659980
cn17	Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Mesp1^tm2(cre)Ysa/Mesp1^+	involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj	MGI:5659978
cn18	Mesp1^tm2(cre)Ysa/Mesp1^+ Tg(CAG-cat,-Notch1)1Ysa/0	involves: C3H * C57BL/6 * CBA	MGI:3702469
cn19	Mesp1^tm2(cre)Ysa/Mesp1^+ Pofut1^tm1Ysa/Pofut1^tm1Ysa Tg(CAG-cat,-Notch1)1Ysa/0	involves: C3H * C57BL/6 * CBA * SJL	MGI:3808715
cn20	Adgrg6^em3Jlp/Adgrg6^em3Jlp Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:7442267
cn21	Adgrg6^em2Jlp/Adgrg6^em3Jlp Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:7442269
cn22	Fgf8^tm2Moon/Fgf8^tm1Mrc Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6 * CBA	MGI:3639730
cn23	Pitx2^tm1.1Mbf/Pitx2^tm1.1Mbf Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6 * CBA	MGI:4880742
cn24	Mesp1^tm2(cre)Ysa/Mesp1^+ Pofut1^tm1Ysa/Pofut1^tm1Ysa	involves: C57BL/6 * CBA * SJL	MGI:3808714
cn25	Chd7^tm2a(EUCOMM)Wtsi/Chd7^tm2a(EUCOMM)Wtsi Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6J * C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7377746
cn26	Tbx1^tm1Dsr/Tbx1^tm1.1Dsr Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:7840104
cn27	Setd5^tm1c(EUCOMM)Wtsi/Setd5^tm1c(EUCOMM)Wtsi Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7543766
cn28	Hacd2^tm1b(EUCOMM)Hmgu/Hacd2^tm1c(EUCOMM)Hmgu Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7447132
cn29	Setd5^tm1c(EUCOMM)Wtsi/Setd5^+ Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7543767
cn30	Fgf10^tm1Ska/Fgf10^tm1Ska Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5661383
cn31	Mesp1^tm2(cre)Ysa/Mesp1^+ Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3829045
cn32	Fgf10^tm1Ska/Fgf10^+ Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5661384
cn33	Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5661382

Genotype
MGI:5780094

cn1

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: B6.Cg-Mesp1^tm2(cre)Ysa Kmt2d^tm1.1Kaig

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229890 )

• no mice are observed after E10.5

embryo

embryonic growth retardation ( J:229890 )

• at E10.5

cardiovascular system

abnormal heart tube morphology ( J:229890 )

• linear at E10.5

pericardial edema ( J:229890 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:229890 )

• at E10.5

homeostasis/metabolism

pericardial edema ( J:229890 )

• at E10.5

Genotype
MGI:4410361

cn2

• Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)

cardiovascular system

abnormal fourth pharyngeal arch artery morphology ( J:154590 )

• in 50% of mice

abnormal sixth pharyngeal arch artery morphology ( J:154590 )

• in 12% of mice

craniofacial

abnormal fourth pharyngeal arch artery morphology ( J:154590 )

• in 50% of mice

abnormal sixth pharyngeal arch artery morphology ( J:154590 )

• in 12% of mice

embryo

abnormal fourth pharyngeal arch artery morphology ( J:154590 )

• in 50% of mice

abnormal sixth pharyngeal arch artery morphology ( J:154590 )

• in 12% of mice

Genotype
MGI:3804087

cn3

• Allelic Composition: Cited2^tm1Bha/Cited2^tm2Bha; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

cardiovascular system

ventricular septal defect ( J:137951 )

• while the outflow tract and aortic arch are normal, 3 of 18 mice exhibit septal defects

Genotype
MGI:3808717

cn4

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(CAG-cat,-Notch1)1Ysa/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA

cardiovascular system

abnormal heart morphology ( J:139209 )

• defects in heart morphology and development are unaffected by the presence of the transgene

abnormal heart development ( J:139209 )

• defects in heart morphology and development are unaffected by the presence of the transgene

Genotype
MGI:3808716

cn5

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:139209 )

abnormal heart development ( J:139209 )

• valve formation is abnormal due to a lack of epithelial-mesenchymal transition and defective trabeculae

• trabecular layers are underdeveloped

abnormal atrioventricular cushion morphology ( J:139209 )

• endocardial layers are abnormally detached from myocardial layers

Genotype
MGI:5707468

cn6

• Allelic Composition: Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst}; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:225226 )

• 78% lethality by 21 days of age

prenatal lethality, incomplete penetrance ( J:225226 )

• 26% mortality by E13.5

embryo

embryo phenotype ( J:225226 )

N • embryos grossly normal to E10.5

cardiovascular system

thin myocardium ( J:225226 )

• in 38% of E13.5 embryos

overriding aortic valve ( J:225226 )

• in 69% of E13.5 embryos

atrial septal defect ( J:225226 )

• short atrial septa

ventricular septal defect ( J:225226 )

• 69% with ventricular septal defects in E13.5 embryos

hemorrhage ( J:225226 )

• in 40% of E13.5 embryos

homeostasis/metabolism

edema ( J:225226 )

• in 20% of E13.5 embryos

muscle

thin myocardium ( J:225226 )

• in 38% of E13.5 embryos

Genotype
MGI:5659972

cn7

• Allelic Composition: Dph1^tm1.1Cmch/Dph1^tm1.1Cmch; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

postnatal lethality, incomplete penetrance ( J:214744 )

• 14.5% of mice are viable at weaning, indicating partial lethality

craniofacial

craniofacial phenotype ( J:214744 )

N • no overt palatal phenotype is seen at E17.5 and ossification of palatine bones appears normal

Genotype
MGI:7437667

cn8

• Allelic Composition: Sp8^tm1Smb/Sp8^tm2Smb; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

craniofacial

craniofacial phenotype ( J:200761 )

N • 9 of 10 mice exhibited no detectable craniofacial defects

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

growth/size/body

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

Genotype
MGI:4880743

cn9

• Allelic Composition: Nodal^tm1Mku/Nodal^tm1Mku; Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(Pitx2-lacZ)1Mbf/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

cardiovascular system

abnormal heart looping ( J:167616 )

Genotype
MGI:5470171

cn10

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Zic3^tm2.1Jwb/Y
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:192577 )

♂ • mice are indistinguishable from control mice with normal survival and heart development

Genotype
MGI:5558939

cn11

• Allelic Composition: Megf8^tm1.2Ddg/Megf8^tm1.2Ddg; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

cardiovascular system phenotype ( J:206541 )

N • mice exhibit a normal heart phenotype

Genotype
MGI:3702490

cn12

• Allelic Composition: Hey1^tm1Kkb/Hey1^tm1Kkb; Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(CAG-cat,-Notch1)1Ysa/0
• Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

cardiovascular system

abnormal myocardial trabeculae morphology ( J:108444 )

• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1

abnormal atrioventricular cushion morphology ( J:108444 )

• mutants exhibit ectopic appearance of cell masses in the atrioventricular cushion

abnormal interventricular septum morphology ( J:108444 )

• the interventricular septum is shifted to the right side

muscle

abnormal myocardial trabeculae morphology ( J:108444 )

• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1

Genotype
MGI:3686782

cn13

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tbx1^tm1Bld/Tbx1^tm5Bld
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

cardiovascular system

cardiovascular system phenotype ( J:112457 )

N • exhibit rescue of the outflow tract defects, the formation and remodeling of the 3rd and 6th pharyngeal arch arteries and the hypoplasia of the 2nd pharyngeal arch

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

craniofacial

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

absent fourth pharyngeal arch ( J:112457 )

• exhibit 4th pharyngeal arch aplasia

• however exhibit rescue of the 2nd arch hypoplasia

embryo

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

abnormal neural crest cell migration ( J:112457 )

• the neural crest migration and cranial nerve pathway abnormalities are only marginally improved

absent fourth pharyngeal arch ( J:112457 )

• exhibit 4th pharyngeal arch aplasia

• however exhibit rescue of the 2nd arch hypoplasia

hematopoietic system

athymia ( J:112457 )

• absent at E18.5

immune system

athymia ( J:112457 )

• absent at E18.5

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:112457 )

N • exhbiit rescue of the external ear hypolasia

cellular

abnormal neural crest cell migration ( J:112457 )

• the neural crest migration and cranial nerve pathway abnormalities are only marginally improved

endocrine/exocrine glands

athymia ( J:112457 )

• absent at E18.5

Genotype
MGI:3686776

cn14

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tbx1^tm1Bld/Tbx1^tm3Bld
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:112457 )

absent fourth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent sixth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent third pharyngeal arch artery ( J:112457 )

• absent at E10.5

abnormal aortic arch morphology ( J:112457 )

• 100% show aortic arch defects

abnormal cardiac outflow tract development ( J:112457 )

persistent truncus arteriosus ( J:112457 )

• 100% penetrance

abnormal interventricular septum morphology ( J:112457 )

• 100% penetrance of ventricular septal defect

embryo

abnormal cardiac neural crest cell migration ( J:112457 )

• the post-otic stream directed to the 3rd pharyngeal arch is interrupted and the circumpharyngeal stream is abnormally distributed

abnormal cranial neural crest cell migration ( J:112457 )

• the pre-otic stream on neural crest cells directed to the 2nd pharyngeal arch is reduced

abnormal pharyngeal arch morphology ( J:112457 )

abnormal pharyngeal arch artery morphology ( J:112457 )

absent fourth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent sixth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent third pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent fourth pharyngeal arch ( J:112457 )

• exhibit loss of the 4th pharyngeal arch at E10.5

second pharyngeal arch hypoplasia ( J:112457 )

• exhibit hypoplasia of the 2nd pharyngeal arch at E10.5

absent sixth pharyngeal arch ( J:112457 )

• exhibit loss of the 6th pharyngeal arch at E10.5

absent third pharyngeal arch ( J:112457 )

• exhibit loss of the 3rd pharyngeal arch at E10.5

abnormal mesenchyme morphology ( J:112457 )

• exhibit reduced proliferation of mesenchymal cells at E8.5

abnormal fourth pharyngeal pouch morphology ( J:112457 )

• the 4th pouch is smaller

hearing/vestibular/ear

ear lobe hypoplasia ( J:112457 )

• 100% show hypoplastic external ears

hematopoietic system

thymus hypoplasia ( J:112457 )

• 3 of 15 show thymic hypoplasia

athymia ( J:112457 )

• 12 of 15 show thymic aplasia

nervous system

abnormal accessory nerve morphology ( J:112457 )

• terminal projections of the accessory nerve show disarray and are fused with each other

glossopharyngeal nerve hypoplasia ( J:112457 )

• glossopharyngeal nerve is hypoplastic and the terminal projections show disarray and are fused with each other

abnormal mandibular nerve branching ( J:112457 )

• the mandibular branch of the trigeminal nerve is fused caudally with the facial nerve

abnormal vagus nerve morphology ( J:112457 )

• terminal projections of the vagus nerve show disarray and are fused with each other

respiratory system

pharynx hypoplasia ( J:112457 )

• severe

craniofacial

craniofacial phenotype ( J:112457 )

N • do not exhibit cleft palate

abnormal pharyngeal arch morphology ( J:112457 )

abnormal pharyngeal arch artery morphology ( J:112457 )

absent fourth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent sixth pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent third pharyngeal arch artery ( J:112457 )

• absent at E10.5

absent fourth pharyngeal arch ( J:112457 )

• exhibit loss of the 4th pharyngeal arch at E10.5

second pharyngeal arch hypoplasia ( J:112457 )

• exhibit hypoplasia of the 2nd pharyngeal arch at E10.5

absent sixth pharyngeal arch ( J:112457 )

• exhibit loss of the 6th pharyngeal arch at E10.5

absent third pharyngeal arch ( J:112457 )

• exhibit loss of the 3rd pharyngeal arch at E10.5

ear lobe hypoplasia ( J:112457 )

• 100% show hypoplastic external ears

immune system

thymus hypoplasia ( J:112457 )

• 3 of 15 show thymic hypoplasia

athymia ( J:112457 )

• 12 of 15 show thymic aplasia

cellular

abnormal cardiac neural crest cell migration ( J:112457 )

• the post-otic stream directed to the 3rd pharyngeal arch is interrupted and the circumpharyngeal stream is abnormally distributed

abnormal cranial neural crest cell migration ( J:112457 )

• the pre-otic stream on neural crest cells directed to the 2nd pharyngeal arch is reduced

endocrine/exocrine glands

thymus hypoplasia ( J:112457 )

• 3 of 15 show thymic hypoplasia

athymia ( J:112457 )

• 12 of 15 show thymic aplasia

growth/size/body

ear lobe hypoplasia ( J:112457 )

• 100% show hypoplastic external ears

Genotype
MGI:5659981

cn15

• Allelic Composition: Dph1^tm2Bhr/Dph1^tm2Bhr; Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

mortality/aging ( J:214744 )

N • embryos are obtained unlike in triple mutants that are heterozygous for the Dph1 allele

Genotype
MGI:5659980

cn16

• Allelic Composition: Dph1^tm2Bhr/Dph1⁺; Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

embryonic lethality, complete penetrance ( J:214744 )

• no embryos at E10.5

Genotype
MGI:5659978

cn17

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

embryonic lethality, complete penetrance ( J:214744 )

• no embryos at E10.5

Genotype
MGI:3702469

cn18

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(CAG-cat,-Notch1)1Ysa/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

cellular

abnormal myocardial fiber myofibril morphology ( J:108444 )

• cardiac myofibrils are poorly formed

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:108444 )

• embryos do not develop beyond E10.5 and die before E11.5

cardiovascular system

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal myocardial fiber myofibril morphology ( J:108444 )

• cardiac myofibrils are poorly formed

abnormal heart development ( J:108444 )

abnormal atrioventricular cushion morphology ( J:108444 )

• exhibit ectopic appearance of cell masses in the atrioventricular cushion

abnormal heart shape ( J:108444 )

• hearts are deformed in shape with a rough surface morphology

enlarged heart ( J:139209 )

abnormal heart ventricle morphology ( J:108444 )

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal interventricular septum morphology ( J:108444 )

• the interventricular septum is shifted to the right side

dilated heart left ventricle ( J:108444 )

• the left ventricle is expanded

decreased heart right ventricle size ( J:108444 )

• the right ventricle is reduced in size

muscle

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal myocardial fiber myofibril morphology ( J:108444 )

• cardiac myofibrils are poorly formed

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal sarcomere morphology ( J:108444 )

• cardiac myofibrils show an unclear sarcomere structure

growth/size/body

enlarged heart ( J:139209 )

Genotype
MGI:3808715

cn19

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Pofut1^tm1Ysa/Pofut1^tm1Ysa; Tg(CAG-cat,-Notch1)1Ysa/0
• Genetic Background: involves: C3H * C57BL/6 * CBA * SJL

cardiovascular system

abnormal heart development ( J:139209 )

• trabecular layer defects observed in Pofut1^tm1Ysa/Pofut1^tm1Ysa Mesp1^tm2(cre)Ysa/Mesp1⁺ mice are partially rescued

enlarged heart ( J:139209 )

growth/size/body

enlarged heart ( J:139209 )

Genotype
MGI:7442267

cn20

• Allelic Composition: Adgrg6^em3Jlp/Adgrg6^em3Jlp; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:315981 )

• mice are viable from E12.5 to E18.5 and do not show any obvious heart phenotype at E15.5

Genotype
MGI:7442269

cn21

• Allelic Composition: Adgrg6^em2Jlp/Adgrg6^em3Jlp; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:315981 )

• mice exhibit no evidence of embryonic lethality; no cardiac defects are detected at E16.5

Genotype
MGI:3639730

cn22

• Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:109475 )

• severely affected Fgf8-deficient embryos (65%) die by E10

homeostasis/metabolism

pericardial effusion ( J:109475 )

• embryos die by E10 with pericardial effusion in 65% of embryos

edema ( J:109475 )

• embryos die by E10 with generalized edema in 65% of embryos

cardiovascular system

abnormal cardiac outflow tract development ( J:109475 )

• OFTs are short or absent in 65% of embryos

abnormal heart tube morphology ( J:109475 )

• heart tube is hypoplastic in 65% of embryos

transposition of great arteries ( J:109475 )

• 30% of the embryos born show transposition of the great arteries

common atrium ( J:109475 )

• there is a single dilated atrium in 65% of embryos

common ventricle ( J:109475 )

• there is a single dilated ventricle in 65% of embryos

bicuspid aortic valve ( J:109475 )

• 40% of newborns also have a bicuspid aortic valve

bicuspid pulmonary valve ( J:109475 )

• 40% of newborns also have a bicuspid pulmonary valve

decreased heart right ventricle size ( J:109475 )

• 35% of embryos survive but have small right ventricles at midgestation

pericardial effusion ( J:109475 )

• embryos die by E10 with pericardial effusion in 65% of embryos

cellular

increased apoptosis ( J:109475 )

• excess apoptotic cells are detected at the 7-9 somite stage in ventral endoderm and adjacent smooth muscle

decreased cell proliferation ( J:109475 )

• at the 4 somite stage, mutants have 46% fewer proliferating cells in crescent mesoderm; this persisted to the 9 somite stage

• proliferating cells are decreased in the proximal outflow tract and pharyngeal epithelium at the 9 somite stage

Genotype
MGI:4880742

cn23

• Allelic Composition: Pitx2^tm1.1Mbf/Pitx2^tm1.1Mbf; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6 * CBA

cardiovascular system

abnormal heart left atrium auricular region morphology ( J:167616 )

• enlarged

heart right ventricle hypoplasia ( J:167616 )

Genotype
MGI:3808714

cn24

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Pofut1^tm1Ysa/Pofut1^tm1Ysa
• Genetic Background: involves: C57BL/6 * CBA * SJL

mortality/aging

embryonic lethality during organogenesis ( J:139209 )

• mice survive a little longer than knockout mice

cardiovascular system

myocardial trabeculae hypoplasia ( J:139209 )

• trabecular layers are underdeveloped

• endocardial layers are abnormally detached from myocardial layers

abnormal cardiac epithelial to mesenchymal transition ( J:139209 )

abnormal heart development ( J:139209 )

• valve formation is abnormal due to a lack of epithelial-mesenchymal transition and defective trabeculae

abnormal atrioventricular cushion morphology ( J:139209 )

muscle

myocardial trabeculae hypoplasia ( J:139209 )

• trabecular layers are underdeveloped

• endocardial layers are abnormally detached from myocardial layers

Genotype
MGI:7377746

cn25

• Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi}; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

perinatal lethality, complete penetrance ( J:225736 )

• no live pups are born or recorded at P10

lethality throughout fetal growth and development, incomplete penetrance ( J:225736 )

• only ~75% of embryos survive to E15.5, with no necrotic embryos detected up to E13.5; the number of embryos collected at E18.5 is significantly below the expected Mendelian ratios (2 versus expected 9)

cardiovascular system

cardiovascular system phenotype ( J:225736 )

N • at E10.5, all embryos exhibit normal pharyngeal arch artery (PAA) development

interrupted aortic arch, type b ( J:225736 )

• at E15.5, 21% (3 of 14) of embryos show interrupted aortic arch type B (IAA-B)

• IAA-Bs seen at E15.5 are likely due to a PAA remodeling defect

abnormal vein morphology ( J:225736 )

• at E15.5, 90% (9 of 10) embryos show absent or poorly formed venous valves

abnormal coronary vein morphology ( J:225736 )

• at E15.5, coronary veins show either severe truncation of the vessels or ectopic formation of multiple small veins

abnormal myocardial trabeculae morphology ( J:225736 )

• at E15.5, the % of overall thickness of the trabecular layer in the left ventricle is 65% versus 49% in control hearts

abnormal myocardium compact layer morphology ( J:225736 )

• at E15.5, 80% of embryos show myocardial non-compaction

• however, development of the epicardium appears normal at E13.5

thin ventricle myocardium compact layer ( J:225736 )

• at E15.5, the compact myocardial layer of the ventricular wall is thin, esp. in the left ventricle

abnormal cardiac outflow tract development ( J:225736 )

• undifferentiated second heart field (SHF) progenitors are normally added to the arterial pole at E11.5, indicating that outflow tract defects are likely due to subsequent differentiation of SHF-derived cells

abnormal truncus arteriosus septation ( J:225736 )

• at E13.5, one of 10 embryos shows a common arterial trunk (CAT) where the outflow tract is not fully septated into a separate aorta and pulmonary trunk

aortopulmonary window ( J:225736 )

• at E13.5, one of 10 embryos shows an aortopulmonary window above a common set of valves

abnormal heart development ( J:225736 )

• hearts exhibit major septation defects affecting both the arterial and venous poles; great vessel, OFT and septation defects are observed

• at E11.5, the vestibular spine is absent or reduced in size

• at E15.0, cardiac innervation is defective with significantly fewer axonal branch points seen on the dorsal surface of the heart; the % of the dorsal ventricular surface area covered by extending axons is reduced to 27% versus 57% in control hearts

abnormal atrioventricular cushion morphology ( J:225736 )

• at E11.5, the endocardial cushions are abnormally positioned (rotated) within the AV canal

• however, no hypocellular AV cushion defect is noted at t E10.5 or E11.5, indicating that mesenchymal population of the cushions is not affected

double outlet right ventricle ( J:225736 )

• at E15.5, 60% (6 of 10) of hearts show double outlet arising from the right ventricle (DORV)

common atrioventricular valve ( J:225736 )

• at E15.5, all (10 of 10) hearts show a common atrioventricular (AV) valve

double inlet heart left ventricle ( J:225736 )

• at E15.5, all (10 of 10) hearts show double inlet left ventricle (DILV) including interventricular communication and common atrioventricular (AV) valves

atrioventricular septal defect ( J:225736 )

• at E15.5, all (10 of 10) hearts exhibit an atrioventricular septal defect

thin ventricular wall ( J:225736 )

• overall thickness of both the right and left ventricles is significantly reduced

hemorrhage ( J:225736 )

• at E15.5, 64% of embryos display hemorrhaging

abnormal fetal cardiomyocyte physiology ( J:225736 )

• ex vivo, only 39% of E13.5 cardiomyocytes respond to electrical pacing with regular Ca²⁺ transients recorded at the expected 1 s intervals versus 95% of control cells, indicating impaired excitation-contraction coupling

congestive heart failure ( J:225736 )

• at E15.5, over 90% of embryos show severe edema and/or hemorrhaging, indicative of cardiac failure

homeostasis/metabolism

edema ( J:225736 )

• at E15.5, 68% of embryos display severe edema

nervous system

abnormal innervation ( J:225736 )

• at E15.0, cardiac innervation is defective with significantly fewer axonal branch points seen on the dorsal surface of the heart; the % of the dorsal ventricular surface area covered by extending axons is reduced to a 27% versus 57% in control hearts

muscle

abnormal myocardial trabeculae morphology ( J:225736 )

• at E15.5, the % of overall thickness of the trabecular layer in the left ventricle is 65% versus 49% in control hearts

abnormal myocardium compact layer morphology ( J:225736 )

• at E15.5, 80% of embryos show myocardial non-compaction

• however, development of the epicardium appears normal at E13.5

thin ventricle myocardium compact layer ( J:225736 )

• at E15.5, the compact myocardial layer of the ventricular wall is thin, esp. in the left ventricle

Genotype
MGI:7840104

cn26

• Allelic Composition: Tbx1^tm1Dsr/Tbx1^tm1.1Dsr; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

craniofacial

frontal bone hypoplasia ( J:217210 )

interparietal bone hypoplasia ( J:217210 )

small supraoccipital bone ( J:217210 )

parietal bone hypoplasia ( J:217210 )

decreased hyoid bone size ( J:217210 )

short mandible ( J:217210 )

hearing/vestibular/ear

tympanic ring hypoplasia ( J:217210 )

respiratory system

small thyroid cartilage ( J:217210 )

skeleton

frontal bone hypoplasia ( J:217210 )

interparietal bone hypoplasia ( J:217210 )

small supraoccipital bone ( J:217210 )

parietal bone hypoplasia ( J:217210 )

decreased hyoid bone size ( J:217210 )

short mandible ( J:217210 )

small thyroid cartilage ( J:217210 )

clavicle hypoplasia ( J:217210 )

split xiphoid process ( J:217210 )

abnormal cervical atlas morphology ( J:217210 )

• hypoplastic ossification

growth/size/body

frontal bone hypoplasia ( J:217210 )

decreased hyoid bone size ( J:217210 )

short mandible ( J:217210 )

Genotype
MGI:7543766

cn27

• Allelic Composition: Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi}; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:314464 )

• embryos are recovered at expected Mendelian ratios at E10.5 but die before E12.5

growth/size/body

decreased embryo size ( J:314464 )

• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length

embryo

decreased embryo size ( J:314464 )

• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length

cardiovascular system

abnormal cardiac outflow tract development ( J:314464 )

• at E10.5, all (100%) of hearts exhibit a shorter OFT than control hearts

abnormal heart morphology ( J:314464 )

• at E10.5, embryos show varying degrees of abnormal cardiac morphogenesis

abnormal heart atrium morphology ( J:314464 )

• at E10.5, some embryos show poorly developed atria and a thickened atrial wall

common atrium ( J:314464 )

common ventricle ( J:314464 )

abnormal heart shape ( J:314464 )

• at E10.5, 25% of embryos have dumbbell-shaped hearts with a single atrium and a single ventricle

heart right ventricle hypoplasia ( J:314464 )

• at E10.5, some embryos exhibit right ventricular hypoplasia

abnormal interventricular groove morphology ( J:314464 )

• at E10.5, some embryos show no evidence of the interventricular groove

pericardial effusion ( J:314464 )

• at E10.5, 74% of embryos exhibit pericardial effusion

dilated heart ( J:314464 )

• at E10.5, 95% of embryos show abnormal cardiac chamber ballooning by external analysis

dilated heart atrium ( J:314464 )

• at E10.5, all (100%) hearts show abnormal atrial ballooning by H&E analysis

dilated heart ventricle ( J:314464 )

• at E10.5, all (100%) hearts show abnormal ventricular ballooning by H&E analysis

hemorrhage ( J:314464 )

• at E10.5, 16% of embryos exhibit hemorrhage

homeostasis/metabolism

pericardial effusion ( J:314464 )

• at E10.5, 74% of embryos exhibit pericardial effusion

Genotype
MGI:7447132

cn28

• Allelic Composition: Hacd2^{tm1b(EUCOMM)Hmgu}/Hacd2^{tm1c(EUCOMM)Hmgu}; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:333944 )

• all mice are viable and overtly normal and reach adulthood in healthy conditions; moreover, adult mice exhibit normal echocardiographic parameters

Genotype
MGI:7543767

cn29

• Allelic Composition: Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

dilated heart ventricle ( J:314464 )

• at E10.5, one of 6 (17%) hearts show abnormal ventricular ballooning

• however, no OFT phenotype or abnormal atrial ballooning is observed

Genotype
MGI:5661383

cn30

• Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska; Fgf8^tm1Moon/Fgf8^tm1Moon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

abnormal aortic arch morphology ( J:170879 )

• narrow

aberrant origin of the right subclavian artery ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac epithelial to mesenchymal transition ( J:170879 )

• impaired at E10.5

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

• smaller and misshapen at E10.5

double outlet right ventricle ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

ventricular septal defect ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

cellular

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

Genotype
MGI:3829045

cn31

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:143444 )

abnormal cardiac outflow tract development ( J:143444 )

• at E9.5 the outflow tract is significantly shorter compared to controls and at an obtuse angle to the right ventricle

• defects in endothelial to mesenchymal transformation and in cardiac neural crest invasion

• decreased proliferation of ISL1 expressing cells

abnormal heart morphology ( J:143444 )

• 75% of mice have heart defects, most of which are arterial pole abnormalities

persistent truncus arteriosus ( J:143444 )

• seen in 3 of 13 mutants

abnormal heart development ( J:143444 )

• decreased proliferation of ISL1 expressing cells in the second heart field

double outlet right ventricle ( J:143444 )

atrioventricular septal defect ( J:143444 )

• seen in 5 of 13 mutants

ventricular septal defect ( J:143444 )

• seen in 9 of 13 mutants

bicuspid aortic valve ( J:143444 )

• seen in 4 of 13 mutants

Genotype
MGI:5661384

cn32

• Allelic Composition: Fgf10^tm1Ska/Fgf10⁺; Fgf8^tm1Moon/Fgf8^tm1Moon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

abnormal aortic arch morphology ( J:170879 )

• narrow

aberrant origin of the right subclavian artery ( J:170879 )

right aortic arch ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

double outlet right ventricle ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

ventricular septal defect ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

Genotype
MGI:5661382

cn33

• Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

cardiovascular system

aberrant origin of the right subclavian artery ( J:170879 )

right aortic arch ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac epithelial to mesenchymal transition ( J:170879 )

• impaired at E10.5

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

double outlet right ventricle ( J:170879 )

ventricular septal defect ( J:170879 )

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

cellular

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5