Adgrg6^em3Jlp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adgrg6^em3Jlp
• Name: adhesion G protein-coupled receptor G6; endonuclease-mediated mutation 3, Jose Luis de la Pompa
• MGI ID: MGI:7438177
• Synonyms: Gpr126^flox
• Gene: Adgrg6 Location: Chr10:14278327-14421403 bp, - strand Genetic Position: Chr10, 5.43 cM
• Alliance: Adgrg6^em3Jlp page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology flanked exon 7 with loxP sites. Embryos were treated with an homology-directed repair (HDR) enhancer, RS-1, to increase knock-in efficiency. (J:315981)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrg6 Mutation: 63 strains or lines available

References

• Original: J:315981 Torregrosa-Carrion R, et al., Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
• All: 1 reference(s)