Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Nfatc1tm1.1(cre)Bz mutation
(0 available);
any
Nfatc1 mutation
(47 available)
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normal phenotype
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• unexpectedly, mice are viable throughout embryogenesis with no resorptions observed from E11.5 to E18.5 and no cardiac abnormalities detected at E15.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
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normal phenotype
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• mice are viable from E12.5 to E18.5 and do not show any obvious heart phenotype at E15.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
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normal phenotype
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• mice exhibit no evidence of embryonic lethality; no cardiac defects are detected at E16.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
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mortality/aging
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• when the cre transgene is inherited paternally, 73% of embryos are viable past E13.5 and 64% survive to birth
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• when the cre transgene is inherited maternally, embryos do not survive past E13.5
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growth/size/body
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• when the cre transgene is inherited paternally, pups exhibit a marked reduction in overall size at P1
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skeleton
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• when the cre transgene is inherited paternally, pups exhibit stiff joint contractures in the forelimbs and hindlimbs at P1
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cardiovascular system
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• when the cre transgene is inherited paternally, hearts are smaller but otherwise structurally normal at P1; no morphological cardiac defects are noted at E16.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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normal phenotype
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• embryos are viable throughout embryogenesis with no resorptions noted from E11.5 to E18.5 and no cardiac defects detected at E15.5
• adult mice show normal electrocardiogram values and left ventricular function with no significant differences in heart size (heart weight-to-tibia length ratio) or in cardiac histology relative to control mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Adgrg6em3Jlp mutation
(0 available);
any
Adgrg6 mutation
(63 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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|
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normal phenotype
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• mice exhibit no evidence of embryonic lethality; no cardiac defects are detected at E16.5
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