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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rarb-cre)1Mrc
transgene insertion 1, Mario R Capecchi
MGI:2159107
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wnt3tm1Amc/Wnt3tm2Amc
Tg(Rarb-cre)1Mrc/0 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:2450913
cn2
 		Fgf4tm1Mrc/Fgf4tm1.1Mrc
Tg(Rarb-cre)1Mrc/0 		involves: 129S1/Sv * 129X1/SvJ MGI:3713885
cn3
 		Fgf4tm1Mrc/Fgf4tm2Mrc
Tg(Rarb-cre)1Mrc/0 		involves: 129S1/Sv * 129X1/SvJ MGI:2176789
cn4
 		Fgf8tm1Mrc/Fgf8tm2Mrc
Tg(Rarb-cre)1Mrc/0 		Not Specified MGI:2176855
cn5
 		Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Tg(Rarb-cre)1Mrc/0 		Not Specified MGI:3575693


Genotype
MGI:2450913
cn1
Allelic
Composition		 Wnt3tm1Amc/Wnt3tm2Amc
Tg(Rarb-cre)1Mrc/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Rarb-cre)1Mrc mutation (1 available)
Wnt3tm1Amc mutation (0 available); any Wnt3 mutation (25 available)
Wnt3tm2Amc mutation (0 available); any Wnt3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal apical ectodermal ridge morphology ( J:81795 )
• at E10.5, mutant mice exhibit a reduction in the anterior/posterior length of the AER
abnormal forelimb morphology ( J:81795 )
• mutant mice display variable forelimb defects ranging from three digits (anterior digits 1-3) and normal zeugopod (radius and ulna) to one digit (digit 2 or 3) and also zeugopod defects (missing ulna); in most cases, the humerus appears unaffected

embryo
abnormal apical ectodermal ridge morphology ( J:81795 )
• at E10.5, mutant mice exhibit a reduction in the anterior/posterior length of the AER




Genotype
MGI:3713885
cn2
Allelic
Composition		 Fgf4tm1Mrc/Fgf4tm1.1Mrc
Tg(Rarb-cre)1Mrc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf4tm1.1Mrc mutation (0 available); any Fgf4 mutation (29 available)
Fgf4tm1Mrc mutation (0 available); any Fgf4 mutation (29 available)
Tg(Rarb-cre)1Mrc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:60091 )
N
• mutants at E15.5, at birth, and as adults have normal forelimbs




Genotype
MGI:2176789
cn3
Allelic
Composition		 Fgf4tm1Mrc/Fgf4tm2Mrc
Tg(Rarb-cre)1Mrc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf4tm1Mrc mutation (0 available); any Fgf4 mutation (29 available)
Fgf4tm2Mrc mutation (0 available); any Fgf4 mutation (29 available)
Tg(Rarb-cre)1Mrc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:60091 )
N
• no abnormal limbs/digits/tail phenotypes detected

skeleton
skeleton phenotype ( J:60091 )
N
• no abnormal skeleton phenotypes detected




Genotype
MGI:2176855
cn4
Allelic
Composition		 Fgf8tm1Mrc/Fgf8tm2Mrc
Tg(Rarb-cre)1Mrc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1Mrc mutation (0 available); any Fgf8 mutation (18 available)
Fgf8tm2Mrc mutation (0 available); any Fgf8 mutation (18 available)
Tg(Rarb-cre)1Mrc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail

skeleton




Genotype
MGI:3575693
cn5
Allelic
Composition		 Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Tg(Rarb-cre)1Mrc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2tm1Dll mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm1Ipc mutation (0 available); any Aldh1a2 mutation (36 available)
Tg(Rarb-cre)1Mrc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:97213 )
• abnormal flexure of the forepaw digits, especially of second and third digits
syndactyly ( J:97213 )
• partial syndactyly of the second to forth forelimb digits

muscle
muscle phenotype ( J:97213 )
N
• no defect in the size and topology of distal limb muscle groups and their intersections, except for a slight hypoplasia of the extensor radialis muscles

skeleton
skeleton phenotype ( J:97213 )
N
• no defect in digit skeleton

nervous system
abnormal motor neuron innervation pattern ( J:97213 )
• an early embryonic loss of a subset of Lim1+ brachial motoneurons, a mispositioning of Islet1+ neurons and inappropriate axonal projections of the nerves innervating extensor limb muscles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory