Fgf4^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Fgf4^tm1Mrc
• Name: fibroblast growth factor 4; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:1858005
• Synonyms: F4^AP, Fgf4^lox
• Gene: Fgf4 Location: Chr7:144415123-144418982 bp, + strand Genetic Position: Chr7, 88.88 cM
• Alliance: Fgf4^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60091
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the 5' promoter region of the gene and a neomycin resistance gene followed by a loxP site and an alkaline phosphatase gene was inserted into the 3' flanking region of the gene. (J:60091)

Expression

In Mice Carrying this Mutation:

61 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf4 Mutation: 29 strains or lines available

References

• Original: J:60091 Moon AM, et al., Normal limb development in conditional mutants of Fgf4. Development. 2000 Mar;127(5):989-96
• All: 5 reference(s)