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Targeted Allele Detail
Symbol: Aldh1a2tm1Dll
Name: aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pascal Dolle
MGI ID: MGI:2451316
Synonyms: Raldh2neo
Gene: Aldh1a2  Location: Chr9:71123071-71203525 bp, + strand  Genetic Position: Chr9, 39.85 cM
Alliance: Aldh1a2tm1Dll page
Outflow tract septation defects and abnormal patterns of aortic arch-derived arteries in Aldh1a2tm1Dll/Aldh1a2tm1Dll and Aldh1a2tm1Dll/Aldh1a2tm1Ipc mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsExon 4 was flanked by a single loxP site in intron 3 and a floxed neo cassette in intron 4. This allele was shown to be hypomorphic by in situ hybridization and immunohistochemical analysis, which showed reduced levels of transcript and protein in homozygous mutant embyros. (J:81969)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 26 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1a2 Mutation:  36 strains or lines available
Original:  J:81969 Vermot J, et al., Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1763-8
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory