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Aldh1a2 Gene Detail
Summary
  • Symbol
    Aldh1a2
  • Name
    aldehyde dehydrogenase family 1, subfamily A2
  • Synonyms
    Aldh1a7, Raldh2, retinaldehyde dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:107928
    NCBI Gene: 19378
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:71123071-71203525 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1979 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107928
 protein coding gene Chr9:71123071-71203525 (+)
129S1/SvImJ ENSMUSG00200041705
 protein coding gene Chr9:68196374-68276862 (+)
A/J ENSMUSG00195024945
 protein coding gene Chr9:67985259-68065789 (+)
AKR/J ENSMUSG00220035743
 protein coding gene Chr9:68139034-68219531 (+)
BALB/cJ ENSMUSG00180015137
 protein coding gene Chr9:68099577-68180097 (+)
C3H/HeJ ENSMUSG00175011803
 protein coding gene Chr9:68112877-68193402 (+)
C57BL/6NJ ENSMUSG00215029712
 protein coding gene Chr9:68069523-68150002 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032410
 protein coding gene Chr9:68361903-68441799 (+)
CAST/EiJ ENSTCUG00005027042
 protein coding gene Chr9:67921397-68001421 (+)
CBA/J ENSMUSG00210014144
 protein coding gene Chr9:68193557-68274063 (+)
DBA/2J ENSMUSG00185033945
 protein coding gene Chr9:68217304-68297808 (+)
FVB/NJ ENSMUSG00205017631
 protein coding gene Chr9:68490617-68571136 (+)
JF1/MsJ ENSUMUG00000017454
 protein coding gene Chr9:68266230-68346368 (+)
LP/J ENSMUSG00230026399
 protein coding gene Chr9:68391478-68471954 (+)
NOD/ShiLtJ ENSMUSG00190021726
 protein coding gene Chr9:68321439-68401928 (+)
NZO/HlLtJ ENSMUSG00225045506
 protein coding gene Chr9:68526402-68607004 (+)
PWK/PhJ ENSLUMG00010023415
 protein coding gene Chr9:68185766-68266301 (+)
SPRET/EiJ ENSMSPG00010017317
 protein coding gene Chr9:69279027-69356309 (+)
WSB/EiJ ENSIUOG00005023855
 protein coding gene Chr9:67686483-67766996 (+)



Homology
more
  • Human Ortholog
    ALDH1A2, aldehyde dehydrogenase 1 family member A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH1A2, aldehyde dehydrogenase 1 family member A2
  • Synonyms
    DIH4, RALDH2, RALDH2-T, RALDH(II)
  • Links
    NCBI Gene ID: 8854
    UniProt: O94788

  • Chr Location
    15q21.3; chr15:57953424-58497866 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Aldh1a2 mouse models; 1 with human ALDH1A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    92 phenotypes from 6 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 images
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations are largely devoid of retinoic acid and die by embryonic day 10.5 with impaired hindbrain development, failure to turn, lack of limb buds, heart abnormalities, reduced otocysts and a truncated frontonasal region. Mice lacking both Aldh1a1 and Aldh1a2 exhibit azoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1712
  • Tissues
    631
  • cDNA Data
    36
  • Literature Summary
    325
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19378 NCBI Gene Model | MGI Sequence Detail 80455 C57BL/6J ±  kb
    transcript NM_009022 RefSeq | MGI Sequence Detail 2264 ZRU/MplStud  
    polypeptide Q62148 UniProt | EBI | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 38
      Primer pair 33
      Other 42
      Antibodies 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36508, MGI:2143263
    References
    more
    • Summaries
      All 467
      Developmental Gene Expression 325
      Diseases 1
      Gene Ontology 36
      Phenotypes 111
    • Earliest
      J:73612 McCaffrery P, et al., Changing patterns of the retinoic acid system in the developing retina. Dev Biol. 1993 Aug;158(2):390-9
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory