Analysis Tools|
Allele Symbol Allele Name Allele ID |
Igf1r+ wild type MGI:2152990 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• blunted endothelial regeneration after arterial injury compared with wild-type cells
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• blunted endothelial regeneration after arterial injury compared with wild-type cells
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• blunted endothelial regeneration after arterial injury compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median tumor free survival of lactating females is 43 days from the first parturition
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• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
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• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
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• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 of 13 mice die by 6 months of age
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• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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• beginning at 3 months of age, 1 of 13 mice appear to gasp for air
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• beginning at 3 months of age, 1 of 13 mice exhibit less activity than wild-type mice
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• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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| N |
• mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal spleen weight with no significant alterations in hematocrit and WBC, lymphocyte, granulocyte or platelet number in peripheral blood relative to wild-type or single Igf1rtm1.2Mhz heterozygous controls at 6 and 12 months of age
• normal % and absolute number of LSK+ cells in bone marrow and spleen with no evidence of reticulin fibers (myelofibrosis) in bone marrow at 12 months of age, unlike in Zfand2btm1Otin homozygotes
• normal total number of bone marrow cells, with no significant differences in the number of mature myeloid cells or nucleated red cells relative to wild-type or single Igf1rtm1.2Mhz heterozygous controls
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| N |
• mice do NOT develop myeloproliferative neoplasms, unlike Zfand2btm1Otin homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm1Arge is inherited maternally, most mice die perinatally with some exceptions
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• when Igf2rtm1Arge is inherited maternally, most mice die perinatally with some exceptions
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• when Igf2rtm1Arge is inherited maternally, birth weight is 135% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die perinatally with some exceptions
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• most mice die perinatally with some exceptions
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• birth weight is 135% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm2Arge is inherited maternally, most mice die perinatally with some exceptions
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• when Igf2rtm2Arge is inherited maternally, most mice die perinatally with some exceptions
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• when Igf2rtm2Arge is inherited maternally, birth weight is 135% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die perinatally with some exceptions
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• most mice die perinatally with some exceptions
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• birth weight is 135% of normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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