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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecp2tm1Bird
targeted mutation 1, Adrian Bird
MGI:2137555
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mecp2tm1Bird/Y
Ssttm2.1(cre)Zjh/Sst+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5749568
cn2
Mecp2tm1Bird/Y
Pvalbtm1.1(cre)Aibs/Pvalb+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl MGI:5749563
cn3
Mecp2tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N MGI:4999644
cn4
Mecp2tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N MGI:4999647
cn5
Mecp2tm1Bird/Y
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3624719
ot6
Mecp2tm1Bird/Y (129S6.129P2-Mecp2tm1Bird x C57BL/6)F1 MGI:3817461
ot7
Mecp2tm1Bird/Y (129S6.129P2-Mecp2tm1Bird x FVB/N)F1 MGI:3817462
ot8
Mecp2tm1Bird/Y involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:4999649


Genotype
MGI:5749568
cn1
Allelic
Composition
Mecp2tm1Bird/Y
Ssttm2.1(cre)Zjh/Sst+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Ssttm2.1(cre)Zjh mutation (3 available); any Sst mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% mortality by 29-35 weeks of age

behavior/neurological
• mice exhibit repetitive nose-poking behavior in the hole board test
• however, mice do not exhibit motor deficits or alternations in acoustic startle response, partition, or cued memory tests, or differences in anxiety, pre-pulse inhibition, locomotor activity or long-term potentiation
• 50% of mice develop spontaneous epileptic seizures starting at 12 weeks
• mice show generalized tonic clonic seizures during routine handling

nervous system
• 50% of mice develop spontaneous epileptic seizures starting at 12 weeks
• mice show generalized tonic clonic seizures during routine handling




Genotype
MGI:5749563
cn2
Allelic
Composition
Mecp2tm1Bird/Y
Pvalbtm1.1(cre)Aibs/Pvalb+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Pvalbtm1.1(cre)Aibs mutation (1 available); any Pvalb mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% mortality by 29-35 weeks of age

behavior/neurological
• mice develop progressive cued memory deficits, with the difference in freezing response to a conditioned tone becoming significantly different at 15 weeks of age
• mice show a diminished acoustic startle response
• mice develop progressive ataxia that is apparent at 6 weeks and worsens by 20 weeks
• however, mice do not exhibit seizures or stereotypical behaviors
• mice exhibit reduced latency to fall in both the rotarod and dowel walk assays
• mice exhibit impaired performance of the marble-burying test, suggesting forelimb incoordination
• mice develop widely splayed hind limbs after 10 weeks and hind limb retraction after 15 weeks of age
• mice spend more time interacting with novel partner mice in a social behavior assay




Genotype
MGI:4999644
cn3
Allelic
Composition
Mecp2tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive to at least 80 weeks of age

behavior/neurological
N
• mice show similar grooming times to controls
• mice have a nonsignificant trend to reduced total distance traveled
• time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls
• mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age
• at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay
• mice show impaired maximum acoustic startle response to 120dB
• mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls
• mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay
• nest building is impaired
• mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay

nervous system
• 24 week-old mice show increased prepulse inhibition at 74 dB

respiratory system
N
• mice show no alterations in tidal volume or minute volume, and display no apneas




Genotype
MGI:4999647
cn4
Allelic
Composition
Mecp2tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Tg(Slc32a1-cre)2.1Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• around 50% of mutant mice die by 26 weeks

growth/size/body
• mice exhibit a period of rapid weight loss preceding death; initial weight gain is normal

behavior/neurological
N
• at 12 weeks of age, mice show similar responses to controls in thermal nociception assays, indicating that the self-injury observed is not due to impaired nociception
• mice display no anxiety-like phenotypes, indicating that hypoactivity or altered social behavior does not result from increased anxiety
• animals show no increased interest in a novel object than controls at 11-12 weeks
• mice recognize and habituate to a novel vanilla odorant; mutants did spend more time sniffing the novel scent than controls (possible manifestation of repetitive behavior) on the first day, but show no differences on the second day
• in a Morris water maze paradigm, animals show a similar rate of learning to control during the 4 training days, but have difficulty locating the platform during the probe trial
• time spent grooming is 300% greater than in control mice; excessive grooming leads to fur loss and epidermal lesions in group- and single-housed mice
• mice have impaired maximum acoustic startle response than controls to 120 dB at 8 weeks
• after 5 weeks of age, mice show repetitive behavior such as hindlimb clasping
• at 5 weeks, mice show increased numbers of footslips on a wire grid and impaired dowel walk at 9 weeks
• mice have a shorter latency to fall on an accelerating rotarod at 19 weeks
• at 9 weeks, mice show decreased time wire hang time prior to falling and reduce forelimb grip strength compared to controls
• there is a trend to reduced activity observed at 12 weeks, while 19-week old mice are hypoactive
• male mice begin to show repetitive behaviors after 5 weeks of age such as forelimb stereotypies similar to the mid-line hand-wringing that characterizes Rett syndrome in humans
• animals display a greater tendency to place their nose in the same hole 2 or more sequential times in a holeboard assay for head-dipping stereotypy
• mice are poor nest builders, possibly due to social behavior alterations or to forelimb apraxia at 13 weeks
• mice spend more time showing directed interest (sniffing, pawing, rearing) near the novel partner mouse than displayed by controls in a 3-chamber assay of social interaction at 12-13 weeks

nervous system
N
• miniature excitatory postsynaptic current quantal size and frequency are similar to controls
• paired pulse ratio is not significantly altered in neurons
• non-seizure hyperexcitability discharges are frequently observed in cultured neurons, but no electrographic seizures are seen
• impaired LTP induced by theta-burst stimulation of Schaffer collaterals is detected
• amplitude and charge of mIPSCs from layer 2/3 pyramidal neurons of the somatosensory cortex are reduced; no change in frequency is observed
• similar results are observed in autaptic GABAergic striatal neurons
• mice show an increased prepulse inhibition at 78 and 82 dB prepulses at 8 weeks

respiratory system
• coinciding with weight loss, mice display a 42% reduction in tidal volume (and 45% reduction in minute volume)
• mice display frequent apneas of greater than 0.4 second durations, coincident with weight loss
• severe respiratory dysfunction is coincident with weight loss




Genotype
MGI:3624719
cn5
Allelic
Composition
Mecp2tm1Bird/Y
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• frequently exhibit uneven wearing of the teeth

mortality/aging

behavior/neurological
• develop a stiff, uncoordinated gait

craniofacial
• frequently exhibit uneven wearing of the teeth

endocrine/exocrine glands

growth/size/body
• frequently exhibit uneven wearing of the teeth

reproductive system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:67910




Genotype
MGI:3817461
ot6
Allelic
Composition
Mecp2tm1Bird/Y
Genetic
Background
(129S6.129P2-Mecp2tm1Bird x C57BL/6)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no early mortality is observed in contrast to Mecp2-null animals

growth/size/body
• Background Sensitivity: a mild increase (animals are about 1 gram heavier) is observed relative to wild-type or F1 mutants from an FVB/N cross

behavior/neurological
• mice have a decreased startle response relative to wild-type
• Background Sensitivity: mice display impaired performance in coordination tasks like the rotating rod, hanging wire, and dowel walking tests
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity
• mice show increased latency in the hot plate assay
• mice show deficits in nest-building relative to wild-type, with fewer animals building or completing nests than wild-type animals over the same time period
• mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system
• mice show decreased prepulse inhibition at 74 and 82 decibels compared to wild-type

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:135825




Genotype
MGI:3817462
ot7
Allelic
Composition
Mecp2tm1Bird/Y
Genetic
Background
(129S6.129P2-Mecp2tm1Bird x FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no early mortality is observed in contrast to Mecp2-null animals

behavior/neurological
N
• Background Sensitivity: no overt abnormalities are observed; mutants do not exhibit impaired coordination in a variety of tests measured
• mice do not show overt abnormalities like tremor or limb grasping
• percentage of time spent freezing is elevated relative to wild-type when placed back into the conditioning chamber
• percentage of time spent freezing is elevated relative to wild-type when re-exposure to a previously experienced cue
• mice show decrease anxiety-related behavior in open field assays than wild-type mice
• increased number of vertical explorations is observed compared to wild-type; this is indicative of reduced anxiety
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity
• mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system
• mice show decreased prepulse inhibition compared to wild-type

respiratory system
• at 4 months, respiratory pattern is qualitatively different than in wild-type; coefficient of variability of the respiratory rhythm is higher than in wild-type
• increase in apnea incidence (39.5/hour) is observed compared to wild-type (5.8/hour)

growth/size/body
N
• Background Sensitivity: no size difference is detected relative to wild-type, unlike mice on the C57BL/6 background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:135825




Genotype
MGI:4999649
ot8
Allelic
Composition
Mecp2tm1Bird/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not show premature lethality

respiratory system
N
• mice do not exhibit apneas





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last database update
09/12/2023
MGI 6.22
The Jackson Laboratory