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Targeted Allele Detail
Symbol: Ssttm2.1(cre)Zjh
Name: somatostatin; targeted mutation 2.1, Z Josh Huang
MGI ID: MGI:4838416
Synonyms: SOM-iCre, SOM-IRES-Cre, SSTCre, Sst-iCre, Sst-IRES-Cre
Gene: Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Alliance: Ssttm2.1(cre)Zjh page
Germline Transmission:  Earliest citation of germline transmission: J:151755
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Project Collection: Neuroscience Blueprint cre
Allele Type:    Targeted (Knockdown, Recombinase)
Mutation:    Insertion
Ssttm2.1(cre)Zjh expression driven by 1 gene
Mutation detailsA targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the somatostatin locus (Sst). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. This mutation results in a dosage-dependent knock-down of endogenous Sst expression J:279254 . (J:151755)
 Tissue activity of this recombinase allele
Driver: Sst (mouse)
Summary of all recombinase alleles driven by Sst.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Sst Mutation:  29 strains or lines available
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  442 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory